Journal ArticleDOI
Cardiac Resynchronization in Chronic Heart Failure
William T. Abraham,Westby G. Fisher,Andrew L. Smith,David B. Delurgio,Angel R. Leon,Evan Loh,Dusan Z. Kocovic,Milton Packer,Alfredo L. Clavell,David L. Hayes,Myrvin H. Ellestad,Robin J. Trupp,Jackie Underwood,Faith Pickering,Cindy Truex,Peggy McAtee,John C. Messenger +16 more
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TLDR
Cardiac resynchronization results in significant clinical improvement in patients who have moderate-to-severe heart failure and an intraventricular conduction delay.Abstract:
Background Previous studies have suggested that cardiac resynchronization achieved through atrial-synchronized biventricular pacing produces clinical benefits in patients with heart failure who have an intraventricular conduction delay. We conducted a double-blind trial to evaluate this therapeutic approach. Methods Four hundred fifty-three patients with moderate-to-severe symptoms of heart failure associated with an ejection fraction of 35 percent or less and a QRS interval of 130 msec or more were randomly assigned to a cardiac-resynchronization group (228 patients) or to a control group (225 patients) for six months, while conventional therapy for heart failure was maintained. The primary end points were the New York Heart Association functional class, quality of life, and the distance walked in six minutes. Results As compared with the control group, patients assigned to cardiac resynchronization experienced an improvement in the distance walked in six minutes (+39 vs. +10 m, P=0.005), functional clas...read more
Citations
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Journal ArticleDOI
Biventricular pacing and left ventricular pacing in heart failure: similar hemodynamic improvement despite marked electromechanical differences.
Pierre Bordachar,Stephane Lafitte,Sylvain Reuter,Stéphane Garrigue,Prashanthan Sanders,Raymond Roudaut,Pierre Jaïs,Michel Haïssaguerre,Jacques Clémenty +8 more
TL;DR: An acute echocardiographic study comparing hemodynamic and ventricular dyssynchrony parameters during left ventricular pacing and biventricular pacing sought to clarify the mechanisms responsible for similar hemodynamic improvement despite differences in electrical activation.
Journal ArticleDOI
A publicly available virtual cohort of four-chamber heart meshes for cardiac electro-mechanics simulations
Marina Strocchi,Christoph M. Augustin,Matthias A. F. Gsell,Elias Karabelas,Aurel Neic,Karli Gillette,Orod Razeghi,Anton J. Prassl,Edward J. Vigmond,Jonathan M. Behar,Jonathan M. Behar,Justin Gould,Justin Gould,Baldeep S. Sidhu,Baldeep S. Sidhu,Christopher A. Rinaldi,Christopher A. Rinaldi,Martin J. Bishop,Gernot Plank,Steven A. Niederer +19 more
TL;DR: This work has created the first publicly available virtual cohort of twenty-four four-chamber hearts, built from heart failure patients, to facilitate large cohort computational studies and to promote the development of cardiac computational electro-mechanics for clinical applications.
Journal ArticleDOI
Implantable cardioverter-defibrillator patients who are upgraded and respond to cardiac resynchronization therapy have less ventricular arrhythmias compared with nonresponders
Joep Thijssen,C. Jan Willem Borleffs,Victoria Delgado,Johannes B. van Rees,Eline A.Q. Mooyaart,Rutger J. van Bommel,Lieselot van Erven,Eric Boersma,Jeroen J. Bax,Martin J. Schalij +9 more
TL;DR: After upgrade from ICD to CRT-D, nonresponders toCRT showed a significant increase in VA burden requiring appropriate device therapy, and it is hypothesized that CRT may reduce the incidence of VA.
Journal ArticleDOI
Stabilization of the Coronary Sinus Electrode Position with Coronary Stent Implantation to Prevent and Treat Dislocation
Szabolcs Szilágyi,Béla Merkely,Attila Roka,Endre Zima,Gabor A. Fulop,Valentina Kutyifa,Gábor Szücs,Dávid Becker,Astrid Apor,László Gellér +9 more
TL;DR: The aim of this study was to investigate the effectiveness and safety of stent implantation in a CS side vein to stabilize the left ventricular lead position after postoperative or intraoperative dislocation of the electrode.
Journal ArticleDOI
Technical aspects of implantation of LV lead for cardiac resynchronization therapy in chronic heart failure.
TL;DR: In conclusion, both individual learning curve and technical advances significantly influence success rate, procedural, and fluoroscopic times for biventricular system implantation.
References
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Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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Book ChapterDOI
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Journal ArticleDOI
Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction Delay
Serge Cazeau,Christophe Leclercq,Thomas Lavergne,S Walker,Varma C,Cecilia Linde,Stéphane Garrigue,Lukas Kappenberger,G A Haywood,Massimo Santini,Bailleul C,Jean-Claude Daubert,Multisite Stimulation in Cardiomyopathies (Mustic) Study Investigators +12 more
TL;DR: In this article, transvenous atriobiventricular pacemakers (with leads in one atrium and each ventricle) were used to reduce ventricular asynchrony.
Journal Article
The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure
Gordon H. Guyatt,Michael J. Sullivan,Penelope J. Thompson,Ernest L. Fallen,S. O. Pugsley,D W Taylor,Leslie B. Berman +6 more
TL;DR: It is concluded that the 6-minute walk is a useful measure of functional exercise capacity and a suitable measure of outcome for clinical trials in patients with chronic heart failure.
Journal ArticleDOI
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II
Bertram Pitt,Philip A. Poole-Wilson,Robert Segal,Felipe Martinez,Kenneth Dickstein,A. John Camm,Marvin A. Konstam,Günter A.J. Riegger,George Klinger,James D. Neaton,Divakar Sharma,Balasamy Thiyagarajan +11 more
TL;DR: The ELITE II Losartan Heart Failure Survival Study as discussed by the authors showed an association between the angiotensin II antagonist losartan and an unexpected survival benefit in elderly heart-failure patients, compared with captopril, an ACE inhibitor.