Open AccessJournal Article
Cardioprotective effect of root extract of Picrorhiza kurroa (Royle Ex Benth) against isoproterenol-induced cardiotoxicity in rats.
Mukesh Nandave,Shreesh Ojha,Santosh Kumari,Tapas Chandra Nag,Raj D. Mehra,Rajiv Narang,Dharamvir Singh Arya +6 more
TLDR
The results suggest that P. kurroa root extract possesses significant cardioprotective effect, which may be attributed to its antioxidant, anti-peroxidative, and myocardial preservative properties.Abstract:
Normal rats pre-treated with P. kurroa (200 mg/kg) alone did not showed significant change, however, isoproterenol (ISP) administration resulted in hemodynamic and left ventricular dysfunction, oxidative stress, and lipid peroxidation. Such cardiac dysfunction was significantly prevented by P. kurroa root extract pre-treatment. Pre-treatment significantly attenuated the ISP-induced oxidative stress by restoring myocardial superoxide dismutase, catalase, and glutathione peroxidase enzymes except reduced glutathione content. P. kurroa pre-treatment markedly attenuated the ISP-induced rise in lipid peroxidation, thereby prevented leakage of myocyte creatine kinase-MB and lactate dehydrogenase enzymes. The results suggest that P. kurroa root extract possesses significant cardioprotective effect, which may be attributed to its antioxidant, anti-peroxidative, and myocardial preservative properties.read more
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Molecular understanding of the protective role of natural products on isoproterenol-induced myocardial infarction: A review.
TL;DR: Promising results towards the amelioration of ISO-induced myocardial damage are highlighted, which suggest the direction for future research on natural products that could be used to treat MI.
Journal ArticleDOI
Biosynthesis and therapeutic implications of iridoid glycosides from Picrorhiza genus: the road ahead
TL;DR: The current knowledge of all naturally occurring iridoid glycosides from Picrorhiza, their biosynthesis and pharmacological capabilities which could provide the insight into metabolic regulation and the basis for the development of new drugs are summarized.
Journal Article
Amelioration of inflammation by phenolic rich methanolic extract of Ocimum sanctum Linn. leaves in isoproterenol induced myocardial infarction.
S. Kavitha,Febi John,M. Indira +2 more
TL;DR: It is demonstrated that methanolic extract of Tulsi leaves can decrease inflammation in the cardiac tissue of ISP-induced MI in rats and its effect may be through downregulation of oxidative stress and arachidonic acid pathway.
Journal ArticleDOI
Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress.
Nadia Afsheen,Khalil-ur-Rehman,Nazish Jahan,Misbah Ijaz,Asad Manzoor,Khalid Mahmood Khan,Saman Hina +6 more
TL;DR: The results depicted that the group pretreated with HC4 significantly sustained the level of CK-MB, SGOT, and LDH as well as hemodynamic parameters near to normal, thus, the HC4 being safe and inexpensive cardioprotective herbal combination could be considered as an alternate of synthetic drugs.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
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Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
TL;DR: Glutathione peroxidase activity is found to be associated with a relatively stable, nondialyzable, heat-labile, intracellular component which is separable from hemoglobin, by gel filtration and ammonium sulfate precipitation.
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Reactive oxygen species in living systems: source, biochemistry, and role in human disease.
TL;DR: These various principles will be illustrated by considering several thiol compounds by scavenging biologically important reactive oxygen species by preventing their formation, or by repairing the damage they do.