Journal ArticleDOI
Carrageenan: A Wonder Polymer from Marine Algae for Potential Drug Delivery Applications
TLDR
Carrageenans are establishing their worth recently as potential drug carriers owing to their varied range of properties and the constraint of low mechanical strength of reversible gels can be easily eradicated using chemical crosslinking techniques.Abstract:
Background With the advancement in the field of medical science, the idea of sustained release of the therapeutic agents in the patient's body has remained a major thrust for developing advanced drug delivery systems (DDSs). The critical requirement for fabricating these DDSs is to facilitate the delivery of their cargos in a spatio-temporal and pharmacokinetically-controlled manner. Albeit the synthetic polymer-based DDSs normally address the above-mentioned conditions, their potential cytotoxicity and high cost have ultimately constrained their success. Consequently, the utilization of natural polymers for the fabrication of tunable DDSs owing to their biocompatible, biodegradable, and non-toxic nature can be regarded as a significant stride in the field of drug delivery. Marine environment serves as an untapped resource of varied range of materials such as polysaccharides, which can easily be utilized for developing various DDSs. Methods Carrageenans are the sulfated polysaccharides that are extracted from the cell wall of red seaweeds. They exhibit an assimilation of various biological activities such as anti-thrombotic, anti-viral, anticancer, and immunomodulatory properties. The main aim of the presented review is threefold. The first one is to describe the unique physicochemical properties and structural composition of different types of carrageenans. The second is to illustrate the preparation methods of the different carrageenan-based macro- and micro-dimensional DDSs like hydrogels, microparticles, and microspheres respectively. Fabrication techniques of some advanced DDSs such as floating hydrogels, aerogels, and 3-D printed hydrogels have also been discussed in this review. Next, considerable attention has been paid to list down the recent applications of carrageenan-based polymeric architectures in the field of drug delivery. Results Presence of structural variations among the different carrageenan types helps in regulating their temperature and ion-dependent sol-to-gel transition behavior. The constraint of low mechanical strength of reversible gels can be easily eradicated using chemical crosslinking techniques. Carrageenan based-microdimesional DDSs (e.g. microspheres, microparticles) can be utilized for easy and controlled drug administration. Moreover, carrageenans can be fabricated as 3-D printed hydrogels, floating hydrogels, and aerogels for controlled drug delivery applications. Conclusion In order to address the problems associated with many of the available DDSs, carrageenans are establishing their worth recently as potential drug carriers owing to their varied range of properties. Different architectures of carrageenans are currently being explored as advanced DDSs. In the near future, translation of carrageenan-based advanced DDSs in the clinical applications seems inevitable.read more
Citations
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Journal ArticleDOI
A critical review on production of biopolymers from algae biomass and their applications.
Ashokkumar Kartik,Dilipkumar Akhil,Divya Lakshmi,Kannappan Panchamoorthy Gopinath,Jayaseelan Arun,Ramachandran Sivaramakrishnan,Arivalagan Pugazhendhi +6 more
TL;DR: In this article, the potential of algae biomass by comparing various seaweed and microalgae strains was elucidated by comparing microwave assisted, ultrasound assisted, and subcritical water assisted extraction.
Journal ArticleDOI
Recent Advances in Marine-Based Nutraceuticals and Their Health Benefits.
Vida Šimat,Nariman Elabed,Piotr Kulawik,Zafer Ceylan,Ewelina Jamróz,Hatice Yazgan,Martina Čagalj,Joe M. Regenstein,Fatih Özogul +8 more
TL;DR: This review is an update on the recent studies of functional seafood compounds focusing on their potential use as nutraceuticals and health benefits.
Microfluidic electrospray photo-crosslinkable κ-Carrageenan microparticles for wound healing
Journal ArticleDOI
Recent Progress on Polysaccharide-Based Hydrogels for Controlled Delivery of Therapeutic Biomolecules.
M. Isabel Rial-Hermida,Ana Rey-Rico,Barbara Blanco-Fernandez,Natalia Carballo-Pedrares,Eimear M. Byrne,João F. Mano +5 more
TL;DR: In this paper, the authors summarize recent progress in the development of polysaccharide-based hydrogels of diverse nature, alone or in combination with other polymers or drug delivery systems, which have been implemented in the delivery of biotherapeutics in the pharmaceutical and biomedical fields.
Journal ArticleDOI
Marine Polysaccharides for Wound Dressings Application: An Overview.
TL;DR: Wang et al. as discussed by the authors presented the wound healing process and described the characteristics of modern commonly used wound dressing, and the properties of various marine polysaccharides and their application in wound dressing development are outlined.
References
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Journal ArticleDOI
Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: Effect of pore forming agents.
TL;DR: CaCO3 can be an excellent pore forming agent for an effective floating drug delivery system in κC hydrogels preparation as compare to NaHCO3.
Journal ArticleDOI
Trivalent Iron Induced Gelation in Lambda-Carrageenan.
TL;DR: This communication reports gelation of lambda-carrageenan, for the first time, in the presence of trivalent iron ions, which has potential to expand lambda- carragenan's current utility beyond a viscosifying agent.
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Facile preparation of monolithic κ-carrageenan aerogels
Kathirvel Ganesan,Lorenz Ratke +1 more
TL;DR: The aerogels were completely pure, free of specific ions and confirmed to be amorphous by powder X-ray diffraction, meaning these porous materials can provide a matrix with a chelating function which can be used as a host in many applications.
Journal ArticleDOI
Effect of processing parameters on preparation of carrageenan aerogel microparticles.
TL;DR: In conclusion, biodegradable aerogel micro-spherical particles based on three different commercial available carrageenan were produced and shows potential characteristic for drug delivery application.