Book ChapterDOI
Cell Biology of Trypanosoma cruzi
Reads0
Chats0
TLDR
This chapter reviews some aspects of the cell biology of Trypanosoma cruzi, giving emphasis to those aspects related to the ultrastructure of pathogenic protozoa.Abstract:
Publisher Summary Among the protozoa of the Trypanosomatidae family, a large number of species represent agents of diseases, such as Chagas' disease. This chapter reviews some aspects of the cell biology of Trypanosoma cruzi, giving emphasis to those aspects related to the ultrastructure of pathogenic protozoa. Protozoa of the Trypanosomatidae family show, during their, life cycle, several forms which can be easily identified by light microscopy in Giemsa-stained preparations. The chapter also explains the life cycle of T. cruzi. In the life cycle of T. cruzi, there are forms which are able to divide. There is one form, considered to be highly differentiated and responsible for the infectivity of these protozoa, which does not divide. It is highlighted that the trypomastigote form can transform into a rounded form which possesses a free flagellum. This form, which appears in the stomach, is able to transform into either short epimastigotes that start a process of multiplication in the intestinum or into long epimastigotes which move to the more posterior region of the digestive tract of the bug. Cell surface is also emphasized in the chapter.read more
Citations
More filters
Journal ArticleDOI
A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells.
TL;DR: Monoclonal antibodies that recognize sialic acid residues of SSP-3 inhibit attachment of trypomastigotes to host cells, suggesting that the unusual trans-sialidase provides Ssp-3 with structural features required for target cell recognition.
Journal ArticleDOI
In vitro differentiation of Trypanosoma cruzi under chemically defined conditions
TL;DR: Metacyclic trypomastigotes of Trypanosoma cruzi obtained in chemically defined axenic culture are resistant to complement lysis and to macrophage digestion and are able to infect mice with an efficiency similar to that obtained for natural metacyclo-trypomastsigotes obtained from triatomine excreta.
Journal ArticleDOI
The Life cycle of Trypanosoma cruzi revisited
Kevin M. Tyler,David M. Engman +1 more
TL;DR: A revised life cycle of Trypanosoma cruzi is presented, influenced by recent findings and specific questions that remain unresolved.
Book ChapterDOI
Giardia and Giardiasis
TL;DR: The intention here is to give an up-to-date overview of Giardia and giardiasis and provide an insight into the enormous wealth of literature on the subject, as well as highlight the most important recent developments and unresolved questions.
Journal ArticleDOI
Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes
TL;DR: Novel roles for the flagellum in the control of cell size, shape, polarity and division of the protozoan Trypanosoma brucei are demonstrated and it is shown that flageLLum elongation controls formation of cytoskeletal structures (present in the cell body) that act as molecular organizers of the cell.
References
More filters
Journal ArticleDOI
The fluid mosaic model of the structure of cell membranes.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.
Journal ArticleDOI
The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.
TL;DR: The early stages of absorption of intravenously injected horseradish peroxidase in proximal tubules of mouse kidney were studied with a new ultrastructural cytochemical technique, which gives sharp localization and is sensitive to protein transport.
Journal ArticleDOI
A protein factor essential for microtubule assembly
TL;DR: The unique ability of tau to restore the normal features of in vitro microtubules assembly makes it likely that tau is a major regulator of microtubule formation in cells.
Journal ArticleDOI
Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose.
Sheila M. Lanham,D.G. Godfrey +1 more
TL;DR: Salivarian trypanosomes were separated from infected blood by adsorbing the particulate blood components on to DEAE-cellulose columns and eluting the trypanOSomes, confirming previous observations, cyclically transmitted isolations behaving similarly to those which were mechanically transmitted.