Cellular dynamics in the muscle satellite cell niche.
C. Florian Bentzinger,Yu Xin Wang,Yu Xin Wang,Nicolas A. Dumont,Michael A. Rudnicki,Michael A. Rudnicki +5 more
TLDR
The cellular dynamics during muscle regeneration and how disease can lead to perturbation of these mechanisms are discussed.Abstract:
Satellite cells, the quintessential skeletal muscle stem cells, reside in a specialized local environment whose anatomy changes dynamically during tissue regeneration. The plasticity of this niche is attributable to regulation by the stem cells themselves and to a multitude of functionally diverse cell types. In particular, immune cells, fibrogenic cells, vessel-associated cells and committed and differentiated cells of the myogenic lineage have emerged as important constituents of the satellite cell niche. Here, we discuss the cellular dynamics during muscle regeneration and how disease can lead to perturbation of these mechanisms. To define the role of cellular components in the muscle stem cell niche is imperative for the development of cell-based therapies, as well as to better understand the pathobiology of degenerative conditions of the skeletal musculature.read more
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Satellite Cells and Skeletal Muscle Regeneration
Nicolas A. Dumont,C. Florian Bentzinger,C. Florian Bentzinger,Marie-Claude Sincennes,Michael A. Rudnicki,Michael A. Rudnicki +5 more
TL;DR: The goal of this review is to comprehensively summarize the current knowledge on satellite cell characteristics, functions, and behavior in muscle regeneration and in pathological conditions.
Journal ArticleDOI
The central role of muscle stem cells in regenerative failure with aging
TL;DR: A more comprehensive understanding of the interplay of stem cell–intrinsic and extrinsic factors will set the stage for improving cell therapies capable of restoring tissue homeostasis and enhancing muscle repair in the aged.
Journal ArticleDOI
Little Fish, Big Data: Zebrafish as a Model for Cardiovascular and Metabolic Disease
Philipp Gut,Philipp Gut,Sven Reischauer,Sven Reischauer,Didier Y.R. Stainier,Didier Y.R. Stainier,Rima Arnaout,Rima Arnaout +7 more
TL;DR: A comprehensive guide on applications of zebrafish to investigate cardiovascular and metabolic diseases and an impressive regenerative capacity scientists hope to unlock in humans are provided.
Journal ArticleDOI
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.
Laura Lukjanenko,M Juliane Jung,Nagabhooshan Hegde,Claire Perruisseau-Carrier,Eugenia Migliavacca,Michelle Rozo,Sonia Karaz,Guillaume Jacot,Manuel Schmidt,Liangji Li,Sylviane Metairon,Frederic Raymond,Umji Lee,Federico Sizzano,David H. Wilson,David H. Wilson,Nicolas A. Dumont,Nicolas A. Dumont,Alessio Palini,Reinhard Fässler,Pascal Steiner,Patrick Descombes,Michael A. Rudnicki,Michael A. Rudnicki,Chen-Ming Fan,Julia von Maltzahn,Jerome N. Feige,C. Florian Bentzinger +27 more
TL;DR: It is demonstrated that the aged stem cell niche in skeletal muscle contains substantially reduced levels of fibronectin (FN), leading to detrimental consequences for the function and maintenance of muscle stem cells (MuSCs), and the loss of stem cell adhesion to FN in the ECM is identified as a previously unknown aging mechanism.
Journal ArticleDOI
Muscle Satellite Cell Cross-Talk with a Vascular Niche maintains quiescence via VEGF and Notch Signaling
Mayank Verma,Yoko Asakura,Bhavani Sai Rohit Murakonda,Thomas Pengo,Claire Latroche,Bénédicte Chazaud,Linda K. McLoon,Atsushi Asakura +7 more
TL;DR: It is hypothesized that MuSCs recruit capillary ECs via VEGFA, and in return, ECs maintain MuSC quiescence though Dll4, and it is shown that this proximity to the blood vessels was associated with MuSC self-renewal.
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