Chemical Diversity and Bioactivities of Monoterpene Indole Alkaloids (MIAs) from Six Apocynaceae Genera
Afrah E. Mohammed,Zainab H. Abdul-Hameed,Modhi O. Alotaibi,Nahed O. Bawakid,Tariq R. Sobahi,Ahmed Abdel-Lateff,Walied M. Alarif +6 more
TLDR
In this paper, a review of Indole Alkaloids from six genera belonging to the family Apocynaceae is presented, and the genera (Alstonia, Rauvolfia, Kopsia, Ervatamia, and Tabernaemontana, and Rhazya) consist of 400 members and represent 20% of the species.Abstract:
By the end of the twentieth century, the interest in natural compounds as probable sources of drugs has declined and was replaced by other strategies such as molecular target-based drug discovery. However, in the recent times, natural compounds regained their position as extremely important source drug leads. Indole-containing compounds are under clinical use which includes vinblastine and vincristine (anticancer), atevirdine (anti-HIV), yohimbine (erectile dysfunction), reserpine (antihypertension), ajmalicine (vascular disorders), ajmaline (anti-arrhythmic), vincamine (vasodilator), etc. Monoterpene Indole Alkaloids (MIAs) deserve the curiosity and attention of researchers due to their chemical diversity and biological activities. These compounds were considered as an impending source of drug-lead. In this review 444 compounds, were identified from six genera belonging to the family Apocynaceae, will be discussed. These genera (Alstonia, Rauvolfia, Kopsia, Ervatamia, and Tabernaemontana, and Rhazya) consist of 400 members and represent 20% of Apocynaceae species. Only 30 (7.5%) species were investigated, whereas the rest are promising to be investigated. Eleven bioactivities, including antibacterial, antifungal, anti-inflammatory and immunosuppressant activities, were reported. Whereas cytotoxic effect represents 47% of the reported activities. Convincingly, the genera selected in this review are a wealthy source for future anticancer drug lead.read more
Citations
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Therapeutic potential of indole alkaloids in respiratory diseases: A comprehensive review.
Saikat Mitra,Shajuthi Rahman Prova,Sifat Ara Sultana,Rajib Das,Firzan Nainu,Talha Bin Emran,Abu Montakim Tareq,Md. Sahab Uddin,Ali Alqahtani,Kuldeep Dhama,Jesus Simal-Gandara +10 more
TL;DR: In this article, the authors summarized the in-depth therapeutic potential of indole alkaloids against various respiratory disorders, including asthma, emphysema, tuberculosis, cancer, and pulmonary fibrosis.
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Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast
Tengfei Liu,Yuanwei Gou,Bei Zhang,Rui Gao,Chang Dong,Mingming Qi,Lihong Jiang,Xuanwei Ding,Chun Li,Jiazhang Lian +9 more
TL;DR: This work profiles genomic loci flanked by essential genes as stable integration sites in a genome‐wide manner, for stable maintenance of multigene biosynthetic pathways in yeast, and establishes stable yeast cell factories that can produce 119.2 mg L−1 heteroyohimbine alkaloids in shake flasks.
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Biosynthesis of catharanthine in engineered Pichia pastoris
Jucan Gao,Yimeng Zuo,Feng Xiao,Yiling Wang,Dongfang Li,Junhao Xu,Cuifang Ye,Linjuan Feng,Leijie Jiang,Tengfei Liu,Di Gao,Bin Ma,Lei Huang,Zhinan Xu,Jiazhang Lian +14 more
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Bisindole Alkaloids from the Alstonia Species: Recent Isolation, Bioactivity, Biosynthesis, and Synthesis.
TL;DR: In this article, the isolation of bisindoles from various Alstonia species, their bioactivity, putative biosynthesis, and synthesis are discussed, as well as the partial synthesis of alstonisidine, villalstonine, and macrocarpamine.
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Isolation and biological activity of azocine and azocane alkaloids
TL;DR: The structure and bioactivity of alkaloids that contain an azocine (or saturated azocane) ring and the array of sources whence they originate are discussed in this article .
References
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