Journal ArticleDOI
Chemoprevention of rat mammary carcinogenesis by Azadirachta indica leaf fractions: Modulation of hormone status, xenobiotic-metabolizing enzymes, oxidative stress, cell proliferation and apoptosis
TLDR
Results provide evidence for the chemopreventive efficacy of neem leaf fractions in the rat mammary tumour model, with EAF rich in constituent phytochemicals was more effective than MF in modulating multiple molecular targets.About:
This article is published in Food and Chemical Toxicology.The article was published on 2009-08-01. It has received 36 citations till now. The article focuses on the topics: Azadirachta & Protein oxidation.read more
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Potential of neem (Azadirachta indica L.) for prevention and treatment of oncologic diseases.
Shradha M. Patel,Kalyan C. Nagulapalli Venkata,Piyali Bhattacharyya,Gautam Sethi,Anupam Bishayee +4 more
TL;DR: The collective and critical analysis of multiple phytoconstituents of A. indica and their molecular mechanisms implicated in cancer chemopreventive and therapeutic effects based on published preclinical and clinical results are presented.
Journal ArticleDOI
Neem components as potential agents for cancer prevention and treatment
TL;DR: The anti-proliferative and apoptosis-inducing effects of neem components are tumor selective as the effects on normal cells are significantly weaker, and neem extracts sensitize cancer cells to immunotherapy and radiotherapy, and enhance the efficacy of certain cancer chemotherapeutic agents.
Journal ArticleDOI
Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats
TL;DR: In this article, the authors investigated the toxic implications of stem bark extract of Azadirachta indica (A. indica) at 50, 100, 200 and 300 mg/kg body weight in Wistar rats.
Journal ArticleDOI
An overview of Neem (Azadirachta indica) and its potential impact on health
Jose Francisco Islas,Ezeiza Acosta,Zuca G-Buentello,Juan Luis Delgado-Gallegos,María Guadalupe Moreno-Treviño,Bruno Escalante,Jorge E. Moreno-Cuevas +6 more
TL;DR: The health benefits found in diverse compounds and extracts derived from Neem are state, highlighting the mechanisms and pathways in which Neem compounds produce their effects, while warning that the improper and unstandardized conditions to produce extracts can lead to health issues.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
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Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.