Chick Ovalbumin Upstream Promoter-Transcription Factors (COUP-TFs): Coming of Age
Sophia Y. Tsai,Ming-Jer Tsai +1 more
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TLDR
This work has shown that COUP-TFs acts as a “spatially aggregating force” to reprogram other members of the steroid/thyroid hormone receptor superfamily into a single gene family.Abstract:
I. Introduction II. The COUP-TF Gene Family A. Homology to other members of the steroid/thyroid hormone receptor superfamily B. Sequence homology within the COUP-TF gene family III. Biochemical Characteristics A. DNA-binding sites B. Molecular mechanism of COUP-TFs action 1. Competition for occupancy of the binding sites 2. Competition for RXR 3. Active repression 4. Transrepression 5. The role of COUP-TFs in transactivation IV. Expression Patterns of COUP-TFs During Development A. Expression patterns in zebrafish and Xenopus B. Expression patterns in mouse and chick V. Physiological Function of COUP-TFs A. Ectopic expression of svp in Drosophila B. Ectopic expression of COUP-TFI in Xenopus embryos C. Loss of function of COUP-TFI in mice D. Loss of function of COUP-TFII in mice VI. Regulation of the Expression of COUP-TF Genes A. Regulation of COUP-TF by retinoids B. Regulation of COUP-TF by sonic hedgehog (Shh) VII. Perspectivesread more
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Nuclear Hormone Receptors and Gene Expression
Ana Aranda,Angel Pascual +1 more
TL;DR: The characterization of corepressor and coactivator complexes, in concert with the identification of the specific interaction motifs in the receptors, has demonstrated the existence of a general molecular mechanism by which different receptors elicit their transcriptional responses in target genes.
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Orphan nuclear receptors: from gene to function.
TL;DR: I. Nuclear Receptors: General Concepts and Orphans in Search of a Home.
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The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development
TL;DR: The embryonic expression of COUP-TFII, an orphan nuclear receptor, suggests that it may participate in mesenchymal-epithelial interactions required for organogenesis, and the expression of Angiopoietin-1, a proangiogenic soluble factor thought to mediate the mesenchyme-endothelial interactions during heart development and vascular remodeling, is down-regulated in COUP -TFII mutants.
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Different TBX5 interactions in heart and limb defined by Holt–Oram syndrome mutations
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TL;DR: Structural data suggest that organ-specific gene activation by TBX5 is predicated on biophysical interactions with different target DNA sequences.
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Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex.
TL;DR: Findings point to a cross-regulation of BMP, FGF, and WNT signaling in the early telencephalon, integrated by EMX2, and required for normal cortical development.
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