Chronic kidney disease and aging differentially diminish bone material and microarchitecture in C57Bl/6 mice.
Chelsea M. Heveran,Charles A. Schurman,Claire Acevedo,Eric W. Livingston,Danielle Howe,Eric Schaible,Heather B Hunt,Adam Rauff,Eve Donnelly,R. Dana Carpenter,Moshe Levi,Anthony G. Lau,Ted A. Bateman,Tamara Alliston,Karen B. King,Virginia L. Ferguson +15 more
TLDR
It is demonstrated that CKD reduces bone quality, including microarchitecture and bone material properties, and that loss of bone quality with age is compounded by CKD, which may help reconcile why bone mass does not consistently predict fracture in the CKD population, as well as why older individuals with CKD are at high risk of fragility.About:
This article is published in Bone.The article was published on 2019-10-01 and is currently open access. It has received 41 citations till now. The article focuses on the topics: Bone remodeling & Kidney disease.read more
Citations
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Executive summary of the 2017 KDIGO Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) Guideline Update: what’s changed and why it matters
Markus Ketteler,Geoffrey A. Block,Pieter Evenepoel,Masafumi Fukagawa,Charles A. Herzog,Linda M. McCann,Sharon M. Moe,Sharon M. Moe,Rukshana Shroff,Marcello Tonelli,Nigel D Toussaint,Marc G. Vervloet,Mary B. Leonard +12 more
TL;DR: This review highlights key aspects of the 2017 CKD-MBD Guideline Update, with an emphasis on the rationale for the changes made to the original guideline document.
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Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling.
TL;DR: In this article, the authors used two in-silico approaches to test the hypothesis that osteocyte degeneration, due to aging or an osteocyte-intrinsic defect in transforming growth factor beta (TGF-β) signaling (TβRIIocy−/−), is sufficient to compromise essential osteocyte responsibilities of mass transport and exposure to mechanical stimuli.
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Spaceflight-Induced Bone Tissue Changes that Affect Bone Quality and Increase Fracture Risk.
TL;DR: Bone structural and material quality are both affected by microgravity and may, together, jeopardize astronaut operational readiness and lead to increased fracture risk upon return to gravitational loading.
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Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment.
TL;DR: The current understanding of how LCS remodeling impacts LCS morphology, tissue-scale bone composition and mechanical properties, and whole-bone material properties is summarized.
References
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An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments
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TL;DR: In this paper, the authors used a Berkovich indenter to determine hardness and elastic modulus from indentation load-displacement data, and showed that the curve of the curve is not linear, even in the initial stages of the unloading process.
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Guidelines for assessment of bone microstructure in rodents using micro–computed tomography
Mary L. Bouxsein,Stephen K Boyd,Blaine A. Christiansen,Robert E. Guldberg,Karl J. Jepsen,Ralph Müller +5 more
TL;DR: Standard nomenclature, outlined in this article, should be followed for reporting of results of µCT‐derived bone morphometry and density measurements.
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The Amazing Osteocyte
TL;DR: Osteocytes compose 90% to 95% of all bone cells in adult bone and are the longest lived bone cell, up to decades within their mineralized environment.
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Bone Quality — The Material and Structural Basis of Bone Strength and Fragility
Ego Seeman,Pierre D. Delmas +1 more
TL;DR: In this article, a review discusses advances in knowledge regarding the composition and structure of bone, the modeling and remodeling of bone and the formation of bone during growth and its reconstruction in adults.