Journal ArticleDOI
Chronic MAO A and MAO B inhibition decreases the 5-HT1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase
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It is suggested that chronic nonselective and chronic MAO A inhibition causes a down-regulation of the 5-HT1A-mediated inhibition of forskolin-stimulated adenylate cyclase activity.About:
This article is published in European Journal of Pharmacology.The article was published on 1988-09-23. It has received 39 citations till now. The article focuses on the topics: Cyclase activity & Clorgyline.read more
Citations
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Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application.
TL;DR: A diversity of multi-target strategies are proposed for the more efficacious and rapid control of core and co-morbid symptoms of depression, together with improved tolerance relative to currently available agents.
Journal ArticleDOI
The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments
TL;DR: Although there are some contradictions, the bulk of data suggests that antidepressant treatments work in the hippocampus by increasing and decreasing, respectively, serotonergic and noradrenergic neurotransmission.
Journal ArticleDOI
Novel therapeutic approaches beyond the serotonin receptor
TL;DR: Up-regulation of the cAMP and BDNF systems has resulted in a novel model for the mechanism of action of antidepressants and new targets for the development of therapeutic agents.
Journal ArticleDOI
Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration
TL;DR: The majority of evidence supports regional differences in the regulation of central 5-HT(1A) receptor function following repeated agonist or antidepressant administration, which may be due to differences in processes involved in desensitization of the receptor at the cellular level.
Book
Serotonin: From Cell Biology to Pharmacology and Therapeutics
Rodolfo Paoletti,Therapeutics +1 more
TL;DR: Serotonergic receptors: an example of a novel 5-HT11 like binding site in the rabbit caudate nucleus, changing views on the role of serotonergic mechanisms in the control of the sleep-wakefulness cycle.
References
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Journal ArticleDOI
A Highly Sensitive Adenylate Cyclase Assay
TL;DR: The high sensitivity of this method permits detection of the small amounts of cyclic AMP formed at low enzyme concentrations or at early time points in kinetic studies.
Journal ArticleDOI
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
TL;DR: F Forskolin would appear to activate adenylate cyclase through a unique mechanism involving both direct activation of the enzyme and facilitation or potentiation of the modulation of enzyme activity by receptors or the guanyl nucleotide-binding subunit, or both.
Journal ArticleDOI
Some observations upon a new inhibitor of monoamine oxidase in brain tissue.
TL;DR: The hypothesis that in the enzyme prepared, the MAO is a binary system of enzymes each of which has a detectably different sensitivity to this particular inhibitor, is put forward and evidence after dialysis supports this hypothesis.
Journal Article
Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
TL;DR: It is proposed that [3H]5-HT and[3H]-spiroperidol label distinct populations of serotonin receptors in rat brain, designated 5-HT1 and 5- HT2 receptors, respectively.
Journal ArticleDOI
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
P.B. Bradley,G. Engel,Wasyl Feniuk,John R. Fozard,Patrick P.A. Humphrey,Derek N. Middlemiss,Ewan J. Mylecharane,B.P. Richardson,Pramod R. Saxena +8 more
TL;DR: This classification of 5-HT receptors into three main groups is based largely, but not exclusively, on data from studies in isolated peripheral tissues where definitive classification is possible, and is believed that this working classification will be relevant to functional responses to 5- HT in the central nervous system.
Related Papers (5)
Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.
M De Vivo,Saul Maayani +1 more
A quantitative autoradiographic study of serotonin1A receptor regulation: effect of 5,7-dihydroxytryptamine and antidepressant treatments
Serotoninergic but not noradrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors
Pierre U. Blier,C de Montigny +1 more