Journal ArticleDOI
Chronic Myeloid Leukaemia
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This Seminar summarises the presentation, pathophysiology, diagnosis and monitoring technology, treatment options, side-effects, and outcomes of chronic myeloid leukaemia, and discusses the possibility of cure-ie, stable undetectable or low level disease in the absence of medication.About:
This article is published in The Lancet.The article was published on 2015-04-11. It has received 306 citations till now. The article focuses on the topics: Imatinib mesylate.read more
Citations
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Journal ArticleDOI
European cancer mortality predictions for the year 2016 with focus on leukaemias
Matteo Malvezzi,Matteo Malvezzi,Greta Carioli,Paola Bertuccio,Tiziana Rosso,Paolo Boffetta,Fabio Levi,C. La Vecchia,Eva Negri +8 more
TL;DR: The 2016 predictions for EU cancer mortality confirm the favourable trends in rates particularly for men, and continuing falls in mortality, larger in children and young adults, are predicted in leukaemias.
Establishment of the 1st world health organization international genetic referrence panel for quantitation of BCR-ABL mRNA
E. White,P. Matejtschuk,P. Rigsby,J. Gabert,Yirong Wang,S. Branford,N. Muller,N. Beaufils,Emmanuel Beillard,Dolors Colomer,Dana Dvořáková,H. Ehrencrona,Hyun-Gyung Goh,El H. Housni,D. Jones,Veli Kairisto,S. Kamel-Reid,Dw. Kim,S. Langabeer,E. Ma,RD Press,G. Romeo,L. Wang,Katerina Zoi,Timothy P. Hughes,G. Saglio,A. Hochhaus,J. Goldman,P. Metcalfe,Ncp. Cross +29 more
TL;DR: The development of accredited reference reagents that are directly linked to the BCR-ABL international scale is considered a significant milestone in the standardization of this clinically important test, but because they are a limited resource it is suggested that their availability is restricted to manufacturers of secondary reference materials.
Book ChapterDOI
Modeling Human Cancers in Drosophila
Masahiro Sonoshita,Ross L. Cagan +1 more
TL;DR: Novel concepts that Drosophila studies have established for cancer biology, drug discovery, and patient therapy are reviewed, and flies offer rapid, efficient platforms by which novel classes of drugs can be identified as candidate anticancer leads.
Journal ArticleDOI
Long-Term Side Effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
TL;DR: There is increasing evidence that patients whose disease is controlled by TKIs will have greater impact on their quality of life from comorbidities or drug adverse events than from the disease itself.
Journal ArticleDOI
Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells.
Mattias Carlsten,Marcus Järås +1 more
TL;DR: This review focuses on mechanisms that are involved in suppressing NK cells in patients with myeloid leukemia and MDS, and means to restore their full anti-tumor potential, and discusses novel molecular targets and approaches to redirect and/or unleash the NK cells against the leukemic cells.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia
Brian J. Druker,Moshe Talpaz,Debra Resta,Bin Peng,Elisabeth Buchdunger,John Ford,Nicholas B. Lydon,Hagop M. Kantarjian,Renaud Capdeville,Sayuri Ohno-Jones,Charles L. Sawyers +10 more
TL;DR: STI571 is well tolerated and has significant antileukemic activity in patients with CML in whom treatment with interferon alfa had failed and demonstrates the potential for the development of anticancer drugs based on the specific molecular abnormality present in a human cancer.
Journal ArticleDOI
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.
TL;DR: An unsuspected abnormality in all cells from the nine patients with chronic myelogenous leukaemia has been detected with quinacrine fluorescence and various Giemsa staining techniques, suggesting that there may be a hitherto undetected translocation between the long arm of 22 and thelong arm of 9, producing the 9q+ chromosome.
Journal ArticleDOI
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells.
Brian J. Druker,Shu Tamura,Elisabeth Buchdunger,Sayuri Ohno,Gerald M. Segal,Shane Fanning,Jürg Zimmermann,Nicholas B. Lydon +7 more
TL;DR: A compound, designed to inhibit the Abl protein tyrosine kinase, was evaluated for its effects on cells containing the Bcr–Abl fusion protein and it was found that this compound may be useful in the treatment of bcr–abl–positive leukemias.
Journal ArticleDOI
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
Stephen G. O'Brien,François Guilhot,Richard A. Larson,Insa Gathmann,Michele Baccarani,Francisco Cervantes,Jan J. Cornelissen,Thomas Fischer,Andreas Hochhaus,Timothy P. Hughes,Klaus Lechner,Johan Lanng Nielsen,Philippe Rousselot,Josy Reiffers,Giuseppe Saglio,John D. Shepherd,Bengt Simonsson,Alois Gratwohl,John M. Goldman,Hagop M. Kantarjian,Kerry Taylor,Gregor Verhoef,Ann E. Bolton,Renaud Capdeville,Brian J. Druker +24 more
TL;DR: Imatinib was superior to interferon alfa plus low-dose cytarabine as first-line therapy in newly diagnosed chronic-phase CML and was better tolerated than combination therapy.
Related Papers (5)
European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
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Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
Brian J. Druker,François Guilhot,Stephen G. O'Brien,Insa Gathmann,Hagop M. Kantarjian,Norbert Gattermann,Michael W. Deininger,Richard T. Silver,John M. Goldman,Richard Stone,Francisco Cervantes,Andreas Hochhaus,Bayard L. Powell,Janice Gabrilove,Philippe Rousselot,Josy Reiffers,Jan J. Cornelissen,Timothy P. Hughes,Hermine Agis,Thea Kolsen Fischer,Gregor Verhoef,John D. Shepherd,Giuseppe Saglio,Alois Gratwohl,Johan Lanng Nielsen,Jerald P. Radich,Bengt Simonsson,Kerry Taylor,Michele Baccarani,Charlene So,Laurie Letvak,Richard A. Larson +31 more