Journal ArticleDOI
Chronic stress causes frontostriatal reorganization and affects decision-making.
Eduardo Dias-Ferreira,Eduardo Dias-Ferreira,Eduardo Dias-Ferreira,João Carlos Sousa,Irene Melo,Pedro Morgado,Ana Mesquita,João José Cerqueira,Rui M. Costa,Rui M. Costa,Nuno Sousa +10 more
TLDR
It is shown that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions on the basis of their consequences, and the relative advantage of circuits coursing through sensorimotor striatum observed after chronic stress leads to a bias in behavioral strategies toward habit.Abstract:
The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here, we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions on the basis of their consequences. Using two different operant tasks, we revealed that, in making choices, rats subjected to chronic stress became insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying these different behavioral strategies, with atrophy of medial prefrontal cortex and the associative striatum and hypertrophy of the sensorimotor striatum. These data suggest that the relative advantage of circuits coursing through sensorimotor striatum observed after chronic stress leads to a bias in behavioral strategies toward habit.read more
Citations
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Resting-state connectivity biomarkers define neurophysiological subtypes of depression
Andrew T. Drysdale,Logan Grosenick,Logan Grosenick,Jonathan Downar,Katharine Dunlop,Farrokh Mansouri,Yue Meng,Robert N. Fetcho,Benjamin D. Zebley,Desmond J. Oathes,Amit Etkin,Alan F. Schatzberg,Keith Sudheimer,Jennifer Keller,Helen S. Mayberg,Faith M. Gunning,George S. Alexopoulos,Michael D. Fox,Alvaro Pascual-Leone,Henning U. Voss,B. J. Casey,Marc J. Dubin,Conor Liston +22 more
TL;DR: It is shown here that patients with depression can be subdivided into four neurophysiological subtypes defined by distinct patterns of dysfunctional connectivity in limbic and frontostriatal networks, which may be useful for identifying the individuals who are most likely to benefit from targeted neurostimulation therapies.
OtherDOI
Regulation of the hypothalamic-pituitary-adrenocortical stress response
James P. Herman,Jessica M. McKlveen,Sriparna Ghosal,Brittany L. Kopp,Aynara C. Wulsin,Ryan Makinson,Jessie R. Scheimann,Brent Myers +7 more
TL;DR: Chronic stress-induced activation of the HPA axis takes many forms (chronic basal hypersecretion, sensitized stress responses, and even adrenal exhaustion), with manifestation dependent upon factors such as stressor chronicity, intensity, frequency, and modality.
Journal ArticleDOI
Brain on stress: How the social environment gets under the skin
TL;DR: The capacity of brain plasticity to effects of stressful experiences in adult life has only begun to be explored along with the efficacy of top-down strategies for helping the brain change itself, sometimes aided by pharmaceutical agents and other treatments.
Journal ArticleDOI
Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease
Peter Redgrave,Manuel Rodriguez,Manuel Rodriguez,Yoland Smith,Yoland Smith,Maria C. Rodriguez-Oroz,Maria C. Rodriguez-Oroz,Stéphane Lehéricy,Hagai Bergman,Yves Agid,Mahlon R. DeLong,Jose A. Obeso,Jose A. Obeso +12 more
TL;DR: In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour, and patients may be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum.
Journal ArticleDOI
Stress- and Allostasis-Induced Brain Plasticity
TL;DR: The role of brain plasticity in adaptation to, and pathophysiology resulting from, stressful experiences is focused on and interventions to prevent and treat chronic and prevalent health conditions via allodynamic brain mechanisms are considered.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
The Rat Brain in Stereotaxic Coordinates, George Paxinos, Charles Watson (Eds.). Academic Press, San Diego, CA (1982), vii + 153, $35.00, ISBN: 0 125 47620 5
TL;DR: It is shown here how the response of the immune system to repeated exposure to high-energy radiation affects its ability to discriminate between healthy and diseased tissue.
Journal ArticleDOI
Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
TL;DR: As an adjunct to pharmaceutical therapy, social and behavioral interventions such as regular physical activity and social support reduce the chronic stress burden and benefit brain and body health and resilience.
Journal ArticleDOI
The role of the basal ganglia in habit formation
Henry H. Yin,Barbara J. Knowlton +1 more
TL;DR: Recent work combining modern behavioural assays and neurobiological analysis of the basal ganglia has begun to yield insights into the neural basis of habit formation.
Journal ArticleDOI
Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons.
TL;DR: It is raised the possibility that certain forms of chronic stress, by affecting specific neuronal elements in the amygdala, may lead to behavioral manifestations of enhanced emotionality, and stress-induced structural plasticity in amygdala neurons may provide a candidate cellular substrate for affective disorders triggered by chronic stress.