Journal ArticleDOI
circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular carcinoma.
Peng Li,Changho Suh,Runjie Song,Fan Yin,Mei Liu,Huijiao Liu,Shuoqian Ma,Xiaomeng Jia,Xiaohui Lu,Yuting Zhong,Lei Yu,Xiru Li,Xiangdong Li,Xiangdong Li,Xiangdong Li +14 more
TLDR
In this paper, the authors identified a functional RNA, hsa_circ_0000384 (circMRPS35), from public tumor databases using a set of computational analyses, and further identified that circMRPS 35 was highly expressed in 35 pairs of HCC from patients.About:
This article is published in Molecular Therapy.The article was published on 2021-08-25. It has received 30 citations till now. The article focuses on the topics: PTEN & Tensin.read more
Citations
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Non-coding RNA in cancer drug resistance: Underlying mechanisms and clinical applications
Xu Zhou,Xiang Ao,Zhaojun Jia,Yiwen Li,Shouxiang Kuang,C. Du,Jin-yu Zhang,Jianxun Wang,Ying Liu +8 more
TL;DR: The recent findings on the emerging role and underlying mechanisms of ncRNAs involved in cancer drug resistance are summarized and their clinical applications as biomarkers and therapeutic targets in cancer treatment are focused on.
Journal ArticleDOI
Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer
TL;DR: This review focuses on the classification, characterization, biogenesis, functions, functions of circRNAs, and the latest advances in cancer research.
Journal ArticleDOI
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
Zongqiang Hu,Gang Chen,Ying Zhao,Hongqiang Gao,Lai-bang Li,Yan-feng Yin,Jie Jiang,Li Qin Wang,Yu Mang,Yang Gao,Sheng-ning Zhang,Jiang-Hua Ran,Li Li +12 more
TL;DR: In this paper , the effect of exosome-derived circRNAs on CD8 + T-cell dysfunction was investigated by in vitro and in vivo functional experiments, where the function of circCCAR1 was measured by enzyme-linked immunosorbent assay (ELISA), western blotting and flow cytometry.
Journal ArticleDOI
Identification of Novel circRNA-Based ceRNA Network Involved in the Pathogenesis of Gastric Cancer
Dengfa Peng,Li Feng,Huqing Li +2 more
TL;DR: A better understanding of circRNA-related ceRNA regulatory mechanism in the pathogenesis of GC is offered, highlighting two ceRNA networks based on hsa_circ_0000384 and hsa-circ_0000043, which were remarkably higher in GC tissues than those in matched adjacent tumor-free gastric tissues.
Journal ArticleDOI
Circular RNA circPBX3 promotes cisplatin resistance of ovarian cancer cells via interacting with IGF2BP2 to stabilize ATP7A mRNA expression
TL;DR: It is found that circPBX3 was upregulated in ovarian tumor tissues and cisplatin-resistant ovarian cancer cells, and could interact with the RNA-binding protein IGF2BP2, thus increased the stability of ATP7A mRNA and elevated ATP 7A protein level.
References
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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray,Jacques Ferlay,Isabelle Soerjomataram,Rebecca L. Siegel,Lindsey A. Torre,Ahmedin Jemal +5 more
TL;DR: A status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions.
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Regulation of microRNA biogenesis
Minju Ha,V. Narry Kim +1 more
TL;DR: Small non-coding RNAs that function as guide molecules in RNA silencing are involved in nearly all developmental and pathological processes in animals and their dysregulation is associated with many human diseases.
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The biogenesis, biology and characterization of circular RNAs.
Lasse Sommer Kristensen,Maria S. Andersen,Lotte V. W. Stagsted,Karoline K. Ebbesen,Thomas B. Hansen,Jørgen Kjems +5 more
TL;DR: Advances in high-throughput RNA sequencing and circRNA-specific computational tools have driven the development of state-of-the-art approaches for their identification, and novel approaches to functional characterization are emerging.
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Cell-type specific features of circular RNA expression.
TL;DR: Using an improved computational approach for circular RNA identification, widespread circular RNA expression is found in Drosophila melanogaster and it is estimated that in humans, circular RNA may account for 1% as many molecules as poly(A) RNA.
Journal ArticleDOI
The RNA binding protein quaking regulates formation of circRNAs.
Simon J. Conn,Katherine A. Pillman,Katherine A. Pillman,John Toubia,John Toubia,Vanessa M. Conn,Marika Salmanidis,Caroline A Phillips,Caroline A Phillips,Suraya Roslan,Andreas W. Schreiber,Andreas W. Schreiber,Andreas W. Schreiber,Philip A. Gregory,Philip A. Gregory,Gregory J. Goodall,Gregory J. Goodall +16 more
TL;DR: It is shown that hundreds of circRNAs are regulated during human epithelial-mesenchymal transition (EMT) and that the production of over one-third of abundant circ RNAs is dynamically regulated by the alternative splicing factor, Quaking (QKI), which itself is regulated during EMT.