Journal ArticleDOI
Circulating nucleic acids (CNAs) and cancer--a survey.
M. Fleischhacker,B. Schmidt +1 more
TLDR
In the past few years many experiments showed that tumor-associated alterations can be detected at the DNA and RNA level, and laid the foundation for the development of assays for an early detection of cancer as well as for other clinical means.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2007-01-01. It has received 832 citations till now. The article focuses on the topics: Nucleic acid & Circulating Cell-Free DNA.read more
Citations
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Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
Cell-free nucleic acids as biomarkers in cancer patients
TL;DR: Findings are discussed with a specific focus on the clinical utility of cell-free nucleic acids as blood biomarkers for cancer screening, prognosis and monitoring of the efficacy of anticancer therapies.
Journal ArticleDOI
Liquid Biopsies: Genotyping Circulating Tumor DNA
Luis A. Diaz,Alberto Bardelli +1 more
TL;DR: The ability to detect and quantify tumor mutations has proven effective in tracking tumor dynamics in real time as well as serving as a liquid biopsy that can be used for a variety of clinical and investigational applications not previously possible.
PatentDOI
Circulating Mutant DNA to Assess Tumor Dynamics
TL;DR: In this article, a highly sensitive approach to quantify circulating tumor DNA (ctDNA) in body samples of patients was applied to reliably monitor tumor dynamics in subjects with cancer, especially those who are undergoing surgery or chemotherapy.
Journal ArticleDOI
Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
Nobuyoshi Kosaka,Haruhisa Iguchi,Yusuke Yoshioka,Fumitaka Takeshita,Yasushi Matsuki,Takahiro Ochiya +5 more
TL;DR: It is shown that miRNAs are released through a ceramide-dependent secretory machinery and that the secretory miRNAAs are transferable and functional in the recipient cells and that a tumor-suppressive miRNA secreted via this pathway was transported between cells and exerted gene silencing in the recipients cells, thereby leading to cell growth inhibition.
References
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Journal ArticleDOI
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands
TL;DR: The use of MSP is demonstrated to identify promoter region hypermethylation changes associated with transcriptional inactivation in four important tumor suppressor genes (p16, p15, E-cadherin and von Hippel-Lindau) in human cancer.
Journal ArticleDOI
Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III
TL;DR: A reprint of Avery, MacLeod, and McCarty's article on the 35th anniversary of its original publication.
Journal Article
A Gene Hypermethylation Profile of Human Cancer
TL;DR: An unusual view of the pervasiveness of DNA alterations, in this case an epigenetic change, in human cancer is provided and a powerful set of markers are provided to outline the disruption of critical pathways in tumorigenesis and for derivation of sensitive molecular detection strategies for virtually every human tumor type.
Journal Article
DNA Fragments in the Blood Plasma of Cancer Patients: Quantitations and Evidence for Their Origin from Apoptotic and Necrotic Cells
Sabine Jahr,Hannes Hentze,Sabine Englisch,Dieter Hardt,Frank O. Fackelmayer,Rolf-Dieter Hesch,Rolf Knippers +6 more
TL;DR: By quantitative methylation-specific PCR of the promoter region of the CDKN2A tumor suppressor gene, the fraction of plasma DNA derived from tumor cells is quantified and is consistent with the possibility that apoptotic and necrotic cells are a major source for plasma DNA in cancer patients.
Journal Article
Free DNA in the Serum of Cancer Patients and the Effect of Therapy
TL;DR: The relatively high percentage of cancer patients with apparently normal DNA levels would suggest that this radioimmunoassay may have low diagnostic value, but DNA in the serum may be an important tool for the evaluation of therapy or the comparison of different regimens.
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Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more