Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance
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TLDR
Cirrhosis-associated immune dysfunction phenotypes switch from predominantly "pro-inflammatory" to predominantly "immunodeficient" in patients with stable ascitic cirrhosis and in Patients with severely decompensated cirrhoses and extra-hepatic organ failure (e.g. acute-on-chronic liver failure), respectively.About:
This article is published in Journal of Hepatology.The article was published on 2014-12-01 and is currently open access. It has received 795 citations till now. The article focuses on the topics: Systemic inflammation & Pattern recognition receptor.read more
Citations
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Journal ArticleDOI
The gut-liver axis in liver disease: Pathophysiological basis for therapy.
TL;DR: The identification of the elements of the gut-liver axis primarily damaged in each chronic liver disease offers possibilities to intervention.
Journal ArticleDOI
Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis
Mauro Bernardi,Richard Moreau,Richard Moreau,Paolo Angeli,Bernd Schnabl,Bernd Schnabl,Vicente Arroyo +6 more
TL;DR: The picture of advanced cirrhosis could be seen as the result of an inflammatory syndrome in contradiction with a simple hemodynamic disturbance, as well as the whole spectrum of its manifestations.
Journal ArticleDOI
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
TL;DR: In this paper, the authors summarized cellular drivers and molecular mechanisms of fibrogenesis in chronic liver diseases and discuss their impact for the development of urgently needed anti-fibrotic therapies.
Journal ArticleDOI
Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper
Tobias Boettler,Philip N. Newsome,Philip N. Newsome,Mario U. Mondelli,Mojca Maticic,Elisa Cordero,Markus Cornberg,Thomas Berg +7 more
TL;DR: The challenge hepatologists are facing is to promote telemedicine in the outpatient setting, prioritise outpatient contacts, avoid nosocomial dissemination of the virus to patients and healthcare providers, and at the same time maintain standard care for patients who require immediate medical attention.
Journal ArticleDOI
Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study.
Thomas Marjot,Andrew M. Moon,Jonathan Cook,Sherief Abd-Elsalam,Costica Aloman,Matthew J. Armstrong,Elisa Pose,Erica J. Brenner,Tamsin Cargill,Maria-Andreea Catana,Renumathy Dhanasekaran,Ahad Eshraghian,Ignacio García-Juárez,Upkar S. Gill,Patricia D. Jones,James Kennedy,Aileen Marshall,Charmaine Matthews,George F. Mells,Carolyn Mercer,Ponni V. Perumalswami,Emma Avitabile,Xialong Qi,Feng Su,Nneka N. Ufere,Yu Jun Wong,Ming-Hua Zheng,Eleanor Barnes,Alfred S. Barritt,Gwilym J. Webb,Gwilym J. Webb +30 more
TL;DR: It is demonstrated that baseline liver disease stage and ALD are independent risk factor for death from COVID-19, which is the largest reported cohort of CLD and cirrhosis patients with SARS-CoV-2 infection to date.
References
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Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis
Richard Moreau,Rajiv Jalan,Pere Ginès,Marco Pavesi,Paolo Angeli,Juan Córdoba,François Durand,Thierry Gustot,Faouzi Saliba,Marco Domenicali,Alexander L. Gerbes,Julia Wendon,Carlo Alessandria,Wim Laleman,Stefan Zeuzem,Jonel Trebicka,Mauro Bernardi,Vicente Arroyo +17 more
TL;DR: Diagnostic criteria for ACLF was established and showed that it is distinct from AD, based not only on the presence of organ failure(s) and high mortality rate but also on age, precipitating events, and systemic inflammation.
Journal ArticleDOI
Endotoxin tolerance: new mechanisms, molecules and clinical significance
TL;DR: The recent appreciation of inflammation as a self-regulating process, the relative contribution of MyD88 versus TRIF signaling pathways in inducing activation or tolerance, plasticity of NF-kappaB function and the role of chromatin modification and microRNAs in LPS-induced gene reprogramming urges a re-evaluation of endotoxin tolerance.
Journal ArticleDOI
The liver as an immunological organ
Vito Racanelli,Barbara Rehermann +1 more
TL;DR: The liver is a unique anatomical and immunological site in which antigen‐rich blood from the gastrointestinal tract is pressed through a network of sinusoids and scanned by antigen‐presenting cells and lymphocytes, which may facilitate direct or indirect priming of lymphocyte, modulate the immune response to hepatotrophic pathogens and contribute to some of the unique immunological properties of this organ.
Journal ArticleDOI
Infections in Patients With Cirrhosis Increase Mortality Four-Fold and Should Be Used in Determining Prognosis
Vasiliki Arvaniti,Gennaro D'Amico,Giuseppe Fede,Pinelopi Manousou,Emmanuel Tsochatzis,M. Pleguezuelo,Andrew K. Burroughs +6 more
TL;DR: In patients with cirrhosis, infections increase mortality 4-fold; 30% of patients die within 1 month after infection and another 30% die by 1 year; prospects with prolonged follow-up evaluation and to evaluate preventative strategies are needed.
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The Liver as a Lymphoid Organ
TL;DR: The liver receives blood from both the systemic circulation and the intestine, and in distinctive, thin-walled sinusoids this mixture passes over a large macrophage population, termed Kupffer cells, which has resulted in a distinctive local immune environment.
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