Journal ArticleDOI
Clinical Applications of PET in Oncology
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TLDR
The physics and instrumentation aspects of PET, an analogue of glucose, are described and are being used in diagnosis and follow-up of several malignancies, and the list of articles supporting its use continues to grow.Abstract:
Positron emission tomography (PET) provides metabolic information that has been documented to be useful in patient care. The properties of positron decay permit accurate imaging of the distribution of positron-emitting radiopharmaceuticals. The wide array of positron-emitting radiopharmaceuticals has been used to characterize multiple physiologic and pathologic states. PET is used for characterizing brain disorders such as Alzheimer disease and epilepsy and cardiac disorders such as coronary artery disease and myocardial viability. The neurologic and cardiac applications of PET are not covered in this review. The major utilization of PET clinically is in oncology and consists of imaging the distribution of fluorine 18 fluorodeoxyglucose (FDG). FDG, an analogue of glucose, accumulates in most tumors in a greater amount than it does in normal tissue. FDG PET is being used in diagnosis and follow-up of several malignancies, and the list of articles supporting its use continues to grow. In this review, the ph...read more
Citations
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Journal ArticleDOI
Guidelines for Management of Small Pulmonary Nodules Detected on CT Scans: A Statement from the Fleischner Society
Heber MacMahon,John H. M. Austin,Gordon Gamsu,Christian J. Herold,James R. Jett,David P. Naidich,Edward F. Patz,Stephen J. Swensen +7 more
TL;DR: The authors believe that the time-honored requirement to follow every small indeterminate nodule with serial CT should be revised and new guidelines are proposed for follow-up and management of small pulmonary nodules detected on CT scans.
Journal ArticleDOI
Acid-Mediated Tumor Invasion: a Multidisciplinary Study
TL;DR: The acid-mediated tumor invasion model provides a simple mechanism linking altered glucose metabolism with the ability of tumor cells to form invasive cancers, and in silico simulations using mathematical models provide testable predictions concerning the morphology and cellular and extracellular dynamics at the tumor-host interface.
Journal Article
Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display.
TL;DR: In this article, the authors examined a new way of body diffusion weighted imaging (DWI) using the short TI inversion recovery-echo planar imaging (STIR-EPI) sequence and free breathing scanning (diffusion weighted whole body imaging with background body signal suppression; DWIBS) to obtain three-dimensional displays.
Book ChapterDOI
Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS)
Taro Takahara,Thomas C. Kwee +1 more
TL;DR: Three-dimensional DWIBS can be obtained with this technique, which may allow us to screen for malignancies in the whole body through diffusion weighted whole body imaging with background body signal suppression.
Journal ArticleDOI
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
TL;DR: The results suggest that the fate of normal human cells should be considered in evaluating nutrient deprivation as a strategy for cancer therapy, and that understanding how glutamine metabolism is linked to cell viability might provide new approaches for treatment of cancer.
References
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Journal ArticleDOI
Accelerated image reconstruction using ordered subsets of projection data
H.M. Hudson,R.S. Larkin +1 more
TL;DR: Ordered subsets EM (OS-EM) provides a restoration imposing a natural positivity condition and with close links to the EM algorithm, applicable in both single photon (SPECT) and positron emission tomography (PET).
Journal ArticleDOI
Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients.
Jeffrey E. Gershenwald,William A. Thompson,Paul F. Mansfield,Jeffrey E. Lee,Maria I. Colome,Chi-Hong Tseng,J. Jack Lee,Charles M. Balch,Douglas S. Reintgen,Merrick I. Ross +9 more
TL;DR: In this paper, the effect of pathologic sentinel lymph node (SLN) status with that of other known prognostic factors on recurrence and survival in patients with stage I or II cutaneous melanoma was compared.
Journal ArticleDOI
Accuracy of Positron Emission Tomography for Diagnosis of Pulmonary Nodules and Mass Lesions: A Meta-analysis
Michael K. Gould,Courtney C. Maclean,Courtney C. Maclean,Ware G. Kuschner,Chara E. Rydzak,Chara E. Rydzak,Douglas K Owens +6 more
TL;DR: Positron emission tomography with 18-fluorodeoxyglucose is an accurate noninvasive imaging test for diagnosis of pulmonary nodules and larger mass lesions, although few data exist for nodules smaller than 1 cm in diameter.
Journal ArticleDOI
Resection of Hepatic Metastases From Colorectal Cancer
TL;DR: The size and nature of the extended sample allowed identification of some determinants of favorable prognosis: Dukes' stage of the primary lesion, absence of extrahepatic metastases, and being female.
Journal Article
Application of Annihilation Coincidence Detection to Transaxial Reconstruction Tomography
TL;DR: A study was carried out to investigate the use of annihilation coincidence detection (ACD) in emmision transaxial reconstruction tomography and found that this approach yields a quantitative nuclear medicine imaging device with high detection efficiency.