Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation
Amy L. Putnam,Niloufar Safinia,Andrew Medvec,M Laszkowska,M Wray,M A Mintz,E Trotta,Greg Szot,Weihong Liu,Angela P. Lares,Karim Lee,Adam Laing,Robert I. Lechler,James L. Riley,Jeffrey A. Bluestone,Giovanna Lombardi,Qizhi Tang +16 more
TLDR
The alloantigen‐expanded Tregs had a diverse TCR repertoire and were more potent than PolyTregs in vitro and more effective at controlling allograft injuries in vivo in a humanized mouse model.About:
This article is published in American Journal of Transplantation.The article was published on 2013-11-01 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Regulatory T cell & Transplantation.read more
Citations
More filters
Journal ArticleDOI
Type 1 diabetes immunotherapy using polyclonal regulatory T cells.
Jeffrey A. Bluestone,Jane H. Buckner,Mark Fitch,Stephen E. Gitelman,Shipra Gupta,Marc K. Hellerstein,Kevan C. Herold,Angela P. Lares,Michael R. Lee,Kelvin W. Li,Weihong Liu,S. Alice Long,Lisa M. Masiello,Vinh Son Nguyen,Amy L. Putnam,Mary Rieck,Peter H. Sayre,Qizhi Tang +17 more
TL;DR: A phase 1 trial of adoptive Treg immunotherapy to repair or replace Tregs in type 1 diabetics was reported, and the therapy was safe, supporting efficacy testing in further trials and support the development of a phase 2 trial to test efficacy of the Treg therapy.
Journal ArticleDOI
Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity.
Marco Romano,Giorgia Fanelli,Caraugh Jane Albany,Giulio Giganti,Giulio Giganti,Giovanna Lombardi +5 more
TL;DR: The understanding of Tregs is described, primarily on their ontogenesis, mechanisms of action and methods used in the clinic for isolation and expansion, which will describe the ongoing studies and the results from the first clinical trials with T Regs in the setting of solid organ transplantation and autoimmune disorders.
Journal ArticleDOI
Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
Katherine G. MacDonald,Romy E. Hoeppli,Qing Huang,Jana Gillies,Dan S. Luciani,Paul C. Orban,Raewyn Broady,Megan K. Levings +7 more
TL;DR: The results demonstrate that use of CAR technology to generate potent, functional, and stable alloantigen-specific human Tregs markedly enhances their therapeutic potential in transplantation and sets the stage for using this approach for making antigen-specific T Regs for therapy of multiple diseases.
Journal ArticleDOI
Treg cell-based therapies: challenges and perspectives.
TL;DR: The biology of Treg cells is discussed and new efforts in Treg cell engineering to enhance specificity, stability, functional activity and delivery are described to encourage the clinical use of adoptive TReg cell therapy for non-immune diseases, such as neurological disorders and tissue repair.
Journal ArticleDOI
Advances in islet encapsulation technologies
Tejal A. Desai,Lonnie D. Shea +1 more
TL;DR: Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing the goal of encapsulated islet cell therapy for humans to be closer.
References
More filters
Journal ArticleDOI
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.
TL;DR: Naturally arising CD25+CD4+ regulatory T cells actively maintain immunological self-tolerance, and are a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens.
Journal ArticleDOI
Regulatory T cells in transplantation tolerance.
Kathryn J. Wood,Shimon Sakaguchi +1 more
TL;DR: The origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ TReg cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate.
Journal ArticleDOI
Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics.
Claudio G. Brunstein,Jeffrey S. Miller,Qing Cao,David H. McKenna,Keli L. Hippen,Julie M. Curtsinger,Todd E. DeFor,Bruce L. Levine,Carl H. June,Pablo Rubinstein,Philip B. McGlave,Bruce R. Blazar,John E. Wagner +12 more
TL;DR: There was a reduced incidence of grade II-IV aGVHD with no deleterious effect on risks of infection, relapse, or early mortality and the results set the stage for a definitive study of UCB Treg to determine its potency in preventing allogeneic aGV HD.
Journal ArticleDOI
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
Mauro Di Ianni,Mauro Di Ianni,Franca Falzetti,Alessandra Carotti,Adelmo Terenzi,Flora Castellino,Elisabetta Bonifacio,Beatrice Del Papa,Tiziana Zei,Roberta Iacucci Ostini,Debora Cecchini,Teresa Aloisi,Katia Perruccio,Loredana Ruggeri,Chiara Balucani,Antonio Pierini,Paolo Sportoletti,Cynthia Aristei,Brunangelo Falini,Yair Reisner,Andrea Velardi,Franco Aversa,Massimo F. Martelli +22 more
TL;DR: It is shown for the first time in humans that adoptive transfer of Tregs prevented GVHD in the absence of any posttransplantation immunosuppression, promoted lymphoid reconstitution, improved immunity to opportunistic pathogens, and did not weaken the graft-versus-leukemia effect.
Book ChapterDOI
Regulatory T cells in transplantation tolerance.
TL;DR: The authors' ability to harness tolerance mechanisms will have a major impact in organ transplantation if it becomes possible to minimize drug maintenance, or even wean off immunosuppressive drugs.
Related Papers (5)
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
Mauro Di Ianni,Mauro Di Ianni,Franca Falzetti,Alessandra Carotti,Adelmo Terenzi,Flora Castellino,Elisabetta Bonifacio,Beatrice Del Papa,Tiziana Zei,Roberta Iacucci Ostini,Debora Cecchini,Teresa Aloisi,Katia Perruccio,Loredana Ruggeri,Chiara Balucani,Antonio Pierini,Paolo Sportoletti,Cynthia Aristei,Brunangelo Falini,Yair Reisner,Andrea Velardi,Franco Aversa,Massimo F. Martelli +22 more