Journal ArticleDOI
Combined efficacies of lipoic acid and 2,3-dimercaptosuccinic acid against lead-induced lipid peroxidation in rat liver
TLDR
In combination LA and DMSA completely ameliorated the lead induced oxidative damage and either compound alone was however only partially protective against lead damage.Abstract:
Oxidative stress with subsequent lipid peroxidation has been postulated as one mechanism for lead toxicity. Hence in assessing the protective effects of lipoic acid (LA) and meso 2,3-dimercaptosuccinic acid (DMSA) on lead toxicity, they were tested either separately or in combination for their effects on selected indices of hepatic oxidative stress. Elevated levels of lipid peroxides were accompanied by altered antioxidant defense systems. Lead acetate (Pb - 0.2%) was administered in drinking water for five weeks to induce toxicity. LA (25 mg kg−1 body wt. day−1 i.p) and DMSA (20 mg kg−1 body wt. day−1 i.p) were administered individually and also in combination during the sixth week. Lead damage to the liver was evident in the decreases in hepatic enzymes alanine transaminase (−38%), aspartate transaminase (−42%) and alkaline phosphatase (−43%); increases in lipid peroxidation (+38%); decreases in the antioxidant enzymes catalase (−45%), superoxide dismutase (−40%), glutathione peroxidase (−46%) and decreases in glutathione (−43%) and decreases in glutathione metabolizing enzymes, glutathione reductase (−59%), glucose-6-phosphate dehydrogenase (−27%) and glutathione-S-transferase (−42%). In combination LA and DMSA completely ameliorated the lead induced oxidative damage. Either compound alone was however only partially protective against lead damage.read more
Citations
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Journal ArticleDOI
Advances in metal-induced oxidative stress and human disease
Klaudia Jomová,Marian Valko +1 more
TL;DR: An overview of redox and non-redox metal-induced formation of free radicals and the role of oxidative stress in toxic action of metals is provided.
Journal ArticleDOI
Toxicity of lead: A review with recent updates.
TL;DR: A comprehensive account of recent updates describing health effects of lead exposure, relevant biomarkers and mechanisms involved in lead toxicity, and updates the readers about recent advances in chelation therapy and newer therapeutic strategies, like nanoencapsulation, to treat lead induced toxic manifestations are provided.
Journal Article
Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity.
TL;DR: Antioxidants - vitamins B6, C and E, zinc, taurine, N-acetylcysteine, and alpha-lipoic acid - have been studied in lead-exposed animals and the evidence for their use in lead exposure, alone and in conjunction with chelating agents, is reviewed.
Journal ArticleDOI
Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys
TL;DR: Short and long term studies conducted on Pb or Cd-induced oxidative stress in blood, liver and kidneys as the most prominent target organs of the toxicity of these metals are reviewed and the possible molecular mechanisms of the observed effects are proposed.
Journal ArticleDOI
Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney.
Milena Andjelkovic,Aleksandra Buha Djordjevic,Evica Antonijevic,Biljana Antonijevic,Momcilo Stanic,Jelena Kotur-Stevuljevic,Vesna Spasojevic-Kalimanovska,Milos Jovanovic,Novica Boricic,David R. Wallace,Zorica Bulat +10 more
TL;DR: Comprehensive observations suggest that exposure to Cd and Pb mixtures produces more pronounced effects compared to the response observed after exposure to single metal solutions, however, further research is needed to confirm toxicokinetic or toxicodynamic interactions between these two toxic metals in the organisms.
References
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