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Community-acquired pneumonia
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This article is published in The Lancet.The article was published on 1998-12-19. It has received 1403 citations till now. The article focuses on the topics: Community-acquired pneumonia.read more
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Journal ArticleDOI
FOCUS 1: A randomized, double-blinded, multicentre, phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia
Thomas M. File,Donald E. Low,Paul B. Eckburg,George H. Talbot,H. David Friedland,Jon Lee,Lily Llorens,Ian A. Critchley,Dirk Thye,John Pullman,Philip Giordano,James Welker,Paul Manos,Purvi Mehra,Thomas M. File,Joseph De Santo,Bhaskar Venkateswaralu,Christian Schrock,William Tillis,Jan Alan Winetz,J. Mario Gonzalez,Anthony Ramage,Dwight D. Eisenhower,Coenie Koegelenberg,Ingrid Engelbrecht,Jaco Jurgens,Ishmail Mitha,Johannes Breedt,Mashra Gani,Johannes Roos,Matthys Basson,Louis Van Zyl,Ronel Meeding,Muhammed Fulat,Marius Le Roux,Pablo Bonvehí,Maria Cristina Ganaha,Ana Leticia Gurini,Gustavo Lopardo,Lucia Cristina,Sergio Edwardo Prieto,Claudia Gabriela Rodiguez,Ricardo Augusto Teijeiro,Elida Carmen Pallone,Daniel Horacio Pryluka,Clovis Arns da Cunha,Nilton Brandao da Silva,Antonio Tarcisio de Faria Freire,Carlos Ernesto Ferreira Starling,Jussara Costa Fiterman,Fernando Gongora Rubio,Luis Carlos Losso,Maria Patelli,Juliani Souza Lima,Paulo José Zimermann Teixeira,Maria Auxiliadora Carmo Moreira,Júlio César Abreu de Oliveira,Vsevolod Roudas,Evgeny A. Gamal,Igor Leschenko,Vladimir A. Rudnov,Anna G. Yevdokimova,Arkadiy L. Vertkin,Yuriy M. Ambalov,Irina V. Dvoryashina,Elmira Zilber,Rustem F. Khamitov,Anna N. Galustyan,Olga V. Reshetko,Victoria Arama Senior,Mihaela Flavia Grosan,Gabriela Jimborean,Mihaela Lupse,Gheorgita Aron,Dan Olteanu,Maria Puschita,Claudia Gavris,Voicu Mircea Tudorache,Vania Youroukova,Mila Petkova,Evelina Troshanova,Mari Dzhabalyan,George Kavtaradze,Manana Makhviladze,Revaz Tabukashvili,Marco Pons,Jorge Garbino,Daniel Genne,Madeleine Rothen,Juan Oriz de Saracho,Alberto Capelastegui,Rosario Menéndez,Antoni Torres,Conrado Shum,V Falcó,Emilio Bouza,Jean-Pierre Bru,Benoit Misset,Bruno Mégarbane,Jean Pierre Sollet,Jean-Michel Molina,Klaus Dalhoff,Joachim Lorenz,Wolfgang Petermann,Gernot Rohde,Christian Schumann,Selcuk Tasci,Joachim Zerbst,Wolfgang Auch-Schwelk,Norbert Suttorp,Rolf Henrich,Andreas Fertl,Christian Grohe,Christian Jakobeit,Karl-Matthius Deppermann,Halina Batura-Gabryel,Danuta Pupek-Musialik,Pawe Piotrowicz,Czeslaw Marcisz,Krzysztof Czarnobilski,Renata Jankowska,Krzysztof Janik,Malgorzata Gutowska-Jablonska,Maciej Hamankiewicz,Jan Kus,Andrzej Rydzewski,Jan Dulawa,Ewa Ziolko,Eliza Baranska,Marian Wendland,Ewa Trebas-Pietras,Ireneusz Tyszkiewic,Johannes Bonelli,Zoltán Balikó,Márta Bisits,Gyorgy Losonczy,Zsuzsa Mark,Istvan Albert,Eva Francovszky,Karoly Fonay,Tetiana Tetiana Pertseva,Volodymyr Yefimov,Volodymyr Havrysyuk,Vasyl Melnyk,Lyudmyla Yashyna,Nadiya Monogarova,Yuriy Kolchyn,Roman Dutka,Oleksandr Smolyanyi,Nadiya Tryshchuk,Igor Kaydashev,Victoria Rodionova,Vasyl Neyko,Ivan Chopey,Birute Alekniene,Ginataras Kramilius,Stanislovas Naudziunas,Skaidrius Miliauskas,Vitalija Nausediene,Arvydas Valavicius,Marija Mitic-Milikic,Dusica Celeketic,Zorica Lazic,Nikola Milinic,Tatjana Pejcic,Kai Sukles,Martti Jaanus,Sulev Meriste,Datin Hjh Aziah Ahmad Mahayiddin,Abdul Pazak Bin Abdul Muttalif,Kiew Kuang Kiat,Roslina Binte,Abdul Manap,Noor Aliza bt Md Tarekh,Thanomsak Anekthananon,Piroon Mootsikapun,Poj Intalapaporn,Chaicharn Pothirat,Pinyo Horsin,Charoen Churchottaworn,Anan Wattanathum,Andrej Dukat,Jan Plutinsky +182 more
TL;DR: Ceftaroline fosamil demonstrated high clinical cure and microbiological response rates in hospitalized patients with CAP of PORT risk class III or IV and was well tolerated, with a safety profile similar to that of ceftriaxone and consistent with the cephalosporin class.
Journal ArticleDOI
Evaluation of lung ultrasound for the diagnosis of pneumonia in the ED.
TL;DR: Considering that lung US is a bedside, reliable, rapid, and noninvasive technique, these results suggest it could have a significant role in the diagnostic workup of pneumonia in the ED, even if no sensitivity nor specificity can be inferred from this study.
Journal ArticleDOI
Efficacy of Short-Course Antibiotic Regimens for Community-Acquired Pneumonia: A Meta-analysis
TL;DR: It is suggested that adults with mild to moderate community-acquired pneumonia can be safely and effectively treated with an antibiotic regimen of 7 days or less and reduction in patient exposure to antibiotics may limit the increasing rates of antimicrobial drug resistance, decrease cost, and improve patient adherence and tolerance.
Journal ArticleDOI
Sensitive and specific method for rapid identification of Streptococcus pneumoniae using real-time fluorescence PCR.
James C. McAvin,Patricia A. Reilly,Robert M. Roudabush,William J. Barnes,Ann Salmen,Glen W. Jackson,Kathleen K. Beninga,Alicia Astorga,Ferne K. McCleskey,William B. Huff,Debra M. Niemeyer,Kenton L. Lohman +11 more
TL;DR: Streptococcus pneumoniae was used as a model organism to develop and refine a real-time fluorescence PCR assay and enhanced DNA purification method and will make it adaptable to identification of many bacterial pathogens and provide potential for adaptation to direct detection from patient specimens.
Journal ArticleDOI
Hospitalization in Community‐Dwelling Persons with Alzheimer's Disease: Frequency and Causes
James L. Rudolph,Nicole M. Zanin,Nicole M. Zanin,Richard N. Jones,Edward R. Marcantonio,Tamara G. Fong,Frances M. Yang,Liang Yap,Sharon K. Inouye,Sharon K. Inouye +9 more
TL;DR: To examine the rates of and risk factors for acute hospitalization in a prospective cohort of older community‐dwelling patients with Alzheimer's disease, a large number of patients are diagnosed with AD.
References
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Mortality, morbidity, and psychosocial outcomes of persons spinal cord injured more than 20 years ago.
Gale G. Whiteneck,Susan Charlifue,Hans L. Frankel,M H Fraser,B P Gardner,Kenneth A. Gerhart,K R Krishnan,Robert R. Menter,I Nuseibeh,D J Short,John Russell Silver +10 more
TL;DR: Declines with age were found in measures of handicap and life satisfaction, but three quarters of those interviewed reported generally good health and rated their current quality of life as either good or excellent.
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Causes of death during the first 12 years after spinal cord injury
TL;DR: Though some cause-specific mortality rates for spinal cord injured persons have declined dramatically, many remain substantially above normal and improved methods for preventing and managing these fatal complications must be developed.
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Risk factors for Clostridium difficile carriage and C. difficile-associated diarrhea in a cohort of hospitalized patients
TL;DR: C. difficile was a common Nosocomial infection on this ward, resulting in asymptomatic carriage more often than diarrhea and accounting for one-fifth of all cases of nosocomial diarrhea.
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Risk Factors for Clostridium difficile Carriage and C. difficile-Associated Diarrhea in a Cohort of Hospitalized Patients
TL;DR: In this paper, a prospective cohort study of 399 consecutive patients in a single ward over an 11-month period was conducted to identify risk factors for nosocomial C. difficile colonization and diarrhea.
Journal ArticleDOI
Successful control of Clostridium difficile infection in an elderly care unit through use of a restrictive antibiotic policy.
Cliodna A. M. McNulty,Margaret Logan,Ian P. Donald,Debbie Ennis,Denise Taylor,R. N. Baldwin,Mira Bannerjee,Keith A. V. Cartwright +7 more
TL;DR: The use of narrow-spectrum antibiotics for hospital treatment of community-acquired infections in the elderly should be encouraged.