Journal ArticleDOI
Community-acquired pneumonia
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This article is published in The Lancet.The article was published on 1998-12-19. It has received 1403 citations till now. The article focuses on the topics: Community-acquired pneumonia.read more
Citations
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Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.
Andreas Nerlich,Maren Mieth,Eleftheria Letsiou,Diana Fatykhova,Katja Zscheppang,Aki Imai-Matsushima,Thomas F. Meyer,Lisa Paasch,Timothy J. Mitchell,Mario Tönnies,Torsten T. Bauer,Paul M. Schneider,Jens Neudecker,Jens C. Rückert,Stephan Eggeling,Maria Schimek,Martin Witzenrath,Norbert Suttorp,Stefan Hippenstiel,Andreas C. Hocke +19 more
TL;DR: A novel live-cell imaging based assay is established to analyse mitochondrial function and associated release of mitochondrial DNA (mtDNA) as DAMP in real-time and indicates cellular mtDNA liberation via microvesicles, which may contribute to S.pn.
Journal ArticleDOI
An Elevated Glycemic Gap is Associated With Adverse Outcomes in Diabetic Patients With Community-Acquired Pneumonia.
Po Chuan Chen,Wen I. Liao,Ying Chuan Wang,Wei Chou Chang,Chin-Wung Hsu,Chin-Wung Hsu,Ying Hsin Chen,Shih-Hung Tsai,Shih-Hung Tsai +8 more
TL;DR: Glycemic gaps were associated with adverse outcomes of diabetic CAP patients and the discriminative performance of the calculated glycemic gaps was comparable with those of current clinical scoring systems and may further increase the AUROC of each system.
Journal ArticleDOI
Mitochondrial dysfunction in lung ageing and disease.
TL;DR: The diverse role of mitochondria in individual lung cell populations and what happens when these essential organelles become dysfunctional with ageing and in acute and chronic lung disease are highlighted.
Journal ArticleDOI
Bacteria Etiological Agents Causing Lower Respiratory Tract Infections and Their Resistance Patterns
TL;DR: There is a need to increase surveillance and develop better strategies to curb the increasing prevalence of LRTI in this region of Nepal and many isolates showed appreciable levels of antibiotic resistance due to antibiotic abuse.
Journal ArticleDOI
A Toll-Like Receptor 5 Agonist Improves the Efficacy of Antibiotics in Treatment of Primary and Influenza Virus-Associated Pneumococcal Mouse Infections
Rémi Porte,Delphine Fougeron,Natalia Muñoz-Wolf,Julien Tabareau,Anne-France Georgel,Frédéric Wallet,Christophe Paget,François Trottein,José A. Chabalgoity,Christophe Carnoy,Jean-Claude Sirard +10 more
TL;DR: It is shown that combining antibiotic treatment with the stimulation of mucosal innate immunity is a potent antibacterial strategy against pneumonia, and TLR5 signaling was shown to be mandatory for the efficacy of the combined antibacterial therapy.
References
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Mortality, morbidity, and psychosocial outcomes of persons spinal cord injured more than 20 years ago.
Gale G. Whiteneck,Susan Charlifue,Hans L. Frankel,M H Fraser,B P Gardner,Kenneth A. Gerhart,K R Krishnan,Robert R. Menter,I Nuseibeh,D J Short,John Russell Silver +10 more
TL;DR: Declines with age were found in measures of handicap and life satisfaction, but three quarters of those interviewed reported generally good health and rated their current quality of life as either good or excellent.
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Causes of death during the first 12 years after spinal cord injury
TL;DR: Though some cause-specific mortality rates for spinal cord injured persons have declined dramatically, many remain substantially above normal and improved methods for preventing and managing these fatal complications must be developed.
Journal Article
Risk factors for Clostridium difficile carriage and C. difficile-associated diarrhea in a cohort of hospitalized patients
TL;DR: C. difficile was a common Nosocomial infection on this ward, resulting in asymptomatic carriage more often than diarrhea and accounting for one-fifth of all cases of nosocomial diarrhea.
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Risk Factors for Clostridium difficile Carriage and C. difficile-Associated Diarrhea in a Cohort of Hospitalized Patients
TL;DR: In this paper, a prospective cohort study of 399 consecutive patients in a single ward over an 11-month period was conducted to identify risk factors for nosocomial C. difficile colonization and diarrhea.
Journal ArticleDOI
Successful control of Clostridium difficile infection in an elderly care unit through use of a restrictive antibiotic policy.
Cliodna A. M. McNulty,Margaret Logan,Ian P. Donald,Debbie Ennis,Denise Taylor,R. N. Baldwin,Mira Bannerjee,Keith A. V. Cartwright +7 more
TL;DR: The use of narrow-spectrum antibiotics for hospital treatment of community-acquired infections in the elderly should be encouraged.