Journal ArticleDOI
Community-acquired pneumonia
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This article is published in The Lancet.The article was published on 1998-12-19. It has received 1403 citations till now. The article focuses on the topics: Community-acquired pneumonia.read more
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Role of platelet-activating factor in pneumolysin-induced acute lung injury.
Martin Witzenrath,Birgitt Gutbier,John Owen,Bernd Schmeck,Timothy J. Mitchell,Konstantin Mayer,Michael J. Thomas,Satoshi Ishii,Simone Rosseau,Norbert Suttorp,Hartwig Schütte +10 more
TL;DR: PAF significantly contributed to PLY-induced acute injury in murine lungs, and depended on thromboxane and on the downstream effectors phosphatidylcholine-specific phospholipase C, protein kinaseC, and Rho-kinase.
Journal ArticleDOI
Ethnic comparisons of disease severity in children hospitalized with pneumonia in New Zealand.
TL;DR: To determine if there are ethnic differences in disease severity in children hospitalized with pneumonia in New Zealand, a large number of children from ethnic minority groups have been admitted to hospital with pneumonia.
Journal ArticleDOI
Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia
Martin Witzenrath,Birgitt Gutbier,Bernd Schmeck,Herrmann Tenor,Joachim Seybold,Raimund Kuelzer,Guido Grentzmann,Armin Hatzelmann,Vincent van Laak,Thomas Tschernig,Timothy J. Mitchell,Christian Schudt,Simone Rosseau,Norbert Suttorp,Hartwig Schütte +14 more
TL;DR: In isolated perfused mouse lungs and in human umbilical vein endothelial cell monolayers, selective inhibition of PDE2 markedly decreased pneumolysin-induced hyperpermeability, and selective PDE 2 inhibitors thus may offer a promising therapeutic approach in severe pneumococcal pneumonia.
Journal ArticleDOI
Streptococcus pneumoniae Colonization Disrupts the Microbial Community within the Upper Respiratory Tract of Aging Mice
Netusha Thevaranjan,Fiona J. Whelan,Alicja Puchta,Eta E Ashu,Laura Rossi,Michael G. Surette,Dawn M. E. Bowdish +6 more
TL;DR: It is discovered that age affects the composition of the URT microbiota and that colonization with S. pneumoniae is more disruptive of preexisting communities in older mice, and it is shown that host-pathogen interactions following S pneumoniae colonization can impact the populations of resident microbes, including Staphylococcus and Haemophilus.
Journal ArticleDOI
Detection of pneumonia associated pathogens using a prototype multiplexed pneumonia test in hospitalized patients with severe pneumonia
Berit Schulte,Holm Eickmeyer,Alexandra Heininger,Stephanie Juretzek,Matthias Karrasch,Olivier Denis,Sandrine Roisin,Mathias W. Pletz,Matthias Klein,Sandra Barth,Gerd Lüdke,Anne Thews,Antoni Torres,Catia Cilloniz,Eberhard Straube,Ingo B. Autenrieth,Peter M. Keller +16 more
TL;DR: The Pneumonia Application provides a rapid and moderately sensitive assay for the detection of pneumonia-causing pathogens with minimal hands-on time and device cut-off settings were adjusted for future series production.
References
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Mortality, morbidity, and psychosocial outcomes of persons spinal cord injured more than 20 years ago.
Gale G. Whiteneck,Susan Charlifue,Hans L. Frankel,M H Fraser,B P Gardner,Kenneth A. Gerhart,K R Krishnan,Robert R. Menter,I Nuseibeh,D J Short,John Russell Silver +10 more
TL;DR: Declines with age were found in measures of handicap and life satisfaction, but three quarters of those interviewed reported generally good health and rated their current quality of life as either good or excellent.
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Causes of death during the first 12 years after spinal cord injury
TL;DR: Though some cause-specific mortality rates for spinal cord injured persons have declined dramatically, many remain substantially above normal and improved methods for preventing and managing these fatal complications must be developed.
Journal Article
Risk factors for Clostridium difficile carriage and C. difficile-associated diarrhea in a cohort of hospitalized patients
TL;DR: C. difficile was a common Nosocomial infection on this ward, resulting in asymptomatic carriage more often than diarrhea and accounting for one-fifth of all cases of nosocomial diarrhea.
Journal ArticleDOI
Risk Factors for Clostridium difficile Carriage and C. difficile-Associated Diarrhea in a Cohort of Hospitalized Patients
TL;DR: In this paper, a prospective cohort study of 399 consecutive patients in a single ward over an 11-month period was conducted to identify risk factors for nosocomial C. difficile colonization and diarrhea.
Journal ArticleDOI
Successful control of Clostridium difficile infection in an elderly care unit through use of a restrictive antibiotic policy.
Cliodna A. M. McNulty,Margaret Logan,Ian P. Donald,Debbie Ennis,Denise Taylor,R. N. Baldwin,Mira Bannerjee,Keith A. V. Cartwright +7 more
TL;DR: The use of narrow-spectrum antibiotics for hospital treatment of community-acquired infections in the elderly should be encouraged.