Comorbidities and Mortality in Bipolar Disorder A Swedish National Cohort Study
Casey Crump,Kristina Sundquist,Kristina Sundquist,Marilyn A. Winkleby,Jan Sundquist,Jan Sundquist +5 more
TLDR
Patients with bipolar disorder had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries, and suicide for both women and men and cancer for women only.Abstract:
Importance Bipolar disorder is associated with premature mortality, but the specific causes and underlying pathways are unclear. Objective To examine the physical health effects of bipolar disorder using outpatient and inpatient data for a national population. Design, Setting, and Participants National cohort study of 6 587 036 Swedish adults, including 6618 with bipolar disorder. Main Outcomes and Measures Physical comorbidities diagnosed in any outpatient or inpatient setting nationwide and mortality (January 1, 2003, through December 31, 2009). Results Women and men with bipolar disorder died 9.0 and 8.5 years earlier on average than the rest of the population, respectively. All-cause mortality was increased 2-fold among women (adjusted hazard ratio [aHR], 2.34; 95% CI, 2.16-2.53) and men (aHR, 2.03; 95% CI, 1.85-2.23) with bipolar disorder, compared with the rest of the population. Patients with bipolar disorder had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries, and suicide for both women and men and cancer for women only. Suicide risk was 10-fold among women (aHR, 10.37; 95% CI, 7.36-14.60) and 8-fold among men (aHR, 8.09; 95% CI, 5.98-10.95) with bipolar disorder, compared with the rest of the population. Substance use disorders contributed only modestly to these findings. The association between bipolar disorder and mortality from chronic diseases (ischemic heart disease, diabetes, COPD, or cancer) was weaker among persons with a prior diagnosis of these conditions (aHR, 1.40; 95% CI, 1.26-1.56) than among those without a prior diagnosis (aHR, 2.38; 95% CI, 1.95-2.90; P interaction = .01). Conclusions and Relevance In this large national cohort study, patients with bipolar disorder died prematurely from multiple causes, including cardiovascular disease, diabetes, COPD, influenza or pneumonia, unintentional injuries, and suicide. However, chronic disease mortality among those with more timely medical diagnosis approached that of the general population, suggesting that better provision of primary medical care may effectively reduce premature mortality among persons with bipolar disorder.read more
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Bipolar Disorder and Bone Mineral Density Z-Scores in Relation to Clinical Characteristics and Lithium Medication
TL;DR: Bipolar disorder and bone mineral density - Z-score in relation to clinical characteristics and lithium medications and lithium medication.
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TL;DR: The review of the literature describes the clinical features of bipolar affective disorder (BAD), including unfavorable forms and mixed bipolar conditions, which are difficult to diagnose and treat, and present a negative prognostic factor.
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A systematic review on genome-wide association studies exploring comorbidity in bipolar disorder
Selena Aranda,Esther Jiménez,Lourdes Martorell,Gerard Muntané,Gerard Muntané,Eduard Vieta,Elisabet Vilella +6 more
TL;DR: Evidence is too weak to consider new endophenotypes in BDI, but some genes involved in neurotransmission, stress response, neurogenesis and synaptic plasticity may be associated with comorbid BDI.
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Differential Medication Attitudes to Antihypertensive and Mood Stabilizing Agents in response to an Automated Text-Messaging Adherence Enhancement Intervention.
Peter J. Klein,Michelle E. Aebi,Michelle E. Aebi,Martha Sajatovic,Martha Sajatovic,Colin A. Depp,David J. Moore,Carol Blixen,Carol Blixen,Jennifer B. Levin,Jennifer B. Levin +10 more
TL;DR: Attitudes toward BD and towards mood-stabilizing drugs as well as antihypertensives improved following a mHealth intervention aimed at improving adherence and increased attention to mechanisms of change in mHealth interventions for adherence may facilitate impact.
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Neighborhood deprivation and coronary heart disease in patients with bipolar disorder
Filip Jansåker,Veronica Milos Nymberg,J. Lundquist,Kenta Okuyama,Tsuyoshi Hamano,Kristina Sundquist,Xinjun Li +6 more
TL;DR: In this article , the potential effect of neighborhood deprivation on incident and fatal coronary heart disease (CHD) in patients with bipolar disorder was explored using Cox regression analysis, with hazard ratios (HRs) and 95% confidence intervals (CIs).
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