Comorbidities and Mortality in Bipolar Disorder A Swedish National Cohort Study
Casey Crump,Kristina Sundquist,Kristina Sundquist,Marilyn A. Winkleby,Jan Sundquist,Jan Sundquist +5 more
TLDR
Patients with bipolar disorder had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries, and suicide for both women and men and cancer for women only.Abstract:
Importance Bipolar disorder is associated with premature mortality, but the specific causes and underlying pathways are unclear. Objective To examine the physical health effects of bipolar disorder using outpatient and inpatient data for a national population. Design, Setting, and Participants National cohort study of 6 587 036 Swedish adults, including 6618 with bipolar disorder. Main Outcomes and Measures Physical comorbidities diagnosed in any outpatient or inpatient setting nationwide and mortality (January 1, 2003, through December 31, 2009). Results Women and men with bipolar disorder died 9.0 and 8.5 years earlier on average than the rest of the population, respectively. All-cause mortality was increased 2-fold among women (adjusted hazard ratio [aHR], 2.34; 95% CI, 2.16-2.53) and men (aHR, 2.03; 95% CI, 1.85-2.23) with bipolar disorder, compared with the rest of the population. Patients with bipolar disorder had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries, and suicide for both women and men and cancer for women only. Suicide risk was 10-fold among women (aHR, 10.37; 95% CI, 7.36-14.60) and 8-fold among men (aHR, 8.09; 95% CI, 5.98-10.95) with bipolar disorder, compared with the rest of the population. Substance use disorders contributed only modestly to these findings. The association between bipolar disorder and mortality from chronic diseases (ischemic heart disease, diabetes, COPD, or cancer) was weaker among persons with a prior diagnosis of these conditions (aHR, 1.40; 95% CI, 1.26-1.56) than among those without a prior diagnosis (aHR, 2.38; 95% CI, 1.95-2.90; P interaction = .01). Conclusions and Relevance In this large national cohort study, patients with bipolar disorder died prematurely from multiple causes, including cardiovascular disease, diabetes, COPD, influenza or pneumonia, unintentional injuries, and suicide. However, chronic disease mortality among those with more timely medical diagnosis approached that of the general population, suggesting that better provision of primary medical care may effectively reduce premature mortality among persons with bipolar disorder.read more
Citations
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Steeper aging-related declines in cognitive control processes among adults with bipolar disorders
Adriana Seelye,Paul Thuras,Bridget M. Doane,Christie Clason,Wendy VanVoorst,Snežana Urošević +5 more
TL;DR: Compared to healthy older adults, OABD showed steeper age-related decline in mental flexibility-select EF processes that depend on the integrity of the CC system; accelerated aging decline in CC may pose a mechanism for high risk of functional impairment and dementia in OABd.
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Violent suicidal behaviour in bipolar disorder is associated with nitric oxide synthase 3 gene polymorphism
José Oliveira,Monojit Debnath,Bruno Etain,Meriem Bennabi,Nora Hamdani,Mohamed Lajnef,Mohamed Lajnef,Djaouida Bengoufa,Catherine Fortier,Wahid Boukouaci,Frank Bellivier,Jean-Pierre Kahn,C. Henry,Dominique Charron,Rajagopal Krishnamoorthy,Marion Leboyer,Ryad Tamouza +16 more
TL;DR: By simultaneously analysing variants of three isoforms of nitric oxide synthase (NOS) genes, interindividual genetic liability to suicidal behaviour in bipolar disorder and suicide is explored.
Journal ArticleDOI
Increased risk of chronic liver disease in patients with bipolar disorder: A population-based study.
TL;DR: Male sex, second-generation antipsychotic or antidepressant use, and hyperlipidemia were associated factors for chronic liver disease in patients with bipolar disorder.
Journal ArticleDOI
Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment.
Claudia Pisanu,Donatella Congiu,Mirko Manchia,Mirko Manchia,Paola Caria,Cristina Cocco,Tinuccia Dettori,Daniela Virginia Frau,Elias Manca,Anna Meloni,Mariella Nieddu,Barbara Noli,Federica Pinna,Renato Robledo,Valeria Sogos,Gian-Luca Ferri,Bernardo Carpiniello,Roberta Vanni,Alberto Bocchetta,Giovanni Severino,Raffaella Ardau,Caterina Chillotti,Maria Del Zompo,Alessio Squassina +23 more
TL;DR: The data support previous findings showing that long-term lithium treatment might protect against telomere shortening, and the association between genetically determined LTL and BD in two large genome-wide association datasets.
Journal ArticleDOI
Cardiovascular risk in patients with severe mental illness in Italy
Virginio Salvi,Andrea Aguglia,Francesco Barone-Adesi,Davide Bianchi,C. Donfrancesco,Filippo Dragogna,Luigi Palmieri,Gianluca Serafini,Mario Amore,Claudio Mencacci +9 more
TL;DR: Women with SMI were consistently more at risk than the general population counterpart, even at younger age, according to the 10-year CV risk score.
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