Comorbidities and Mortality in Bipolar Disorder A Swedish National Cohort Study
Casey Crump,Kristina Sundquist,Kristina Sundquist,Marilyn A. Winkleby,Jan Sundquist,Jan Sundquist +5 more
TLDR
Patients with bipolar disorder had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries, and suicide for both women and men and cancer for women only.Abstract:
Importance Bipolar disorder is associated with premature mortality, but the specific causes and underlying pathways are unclear. Objective To examine the physical health effects of bipolar disorder using outpatient and inpatient data for a national population. Design, Setting, and Participants National cohort study of 6 587 036 Swedish adults, including 6618 with bipolar disorder. Main Outcomes and Measures Physical comorbidities diagnosed in any outpatient or inpatient setting nationwide and mortality (January 1, 2003, through December 31, 2009). Results Women and men with bipolar disorder died 9.0 and 8.5 years earlier on average than the rest of the population, respectively. All-cause mortality was increased 2-fold among women (adjusted hazard ratio [aHR], 2.34; 95% CI, 2.16-2.53) and men (aHR, 2.03; 95% CI, 1.85-2.23) with bipolar disorder, compared with the rest of the population. Patients with bipolar disorder had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries, and suicide for both women and men and cancer for women only. Suicide risk was 10-fold among women (aHR, 10.37; 95% CI, 7.36-14.60) and 8-fold among men (aHR, 8.09; 95% CI, 5.98-10.95) with bipolar disorder, compared with the rest of the population. Substance use disorders contributed only modestly to these findings. The association between bipolar disorder and mortality from chronic diseases (ischemic heart disease, diabetes, COPD, or cancer) was weaker among persons with a prior diagnosis of these conditions (aHR, 1.40; 95% CI, 1.26-1.56) than among those without a prior diagnosis (aHR, 2.38; 95% CI, 1.95-2.90; P interaction = .01). Conclusions and Relevance In this large national cohort study, patients with bipolar disorder died prematurely from multiple causes, including cardiovascular disease, diabetes, COPD, influenza or pneumonia, unintentional injuries, and suicide. However, chronic disease mortality among those with more timely medical diagnosis approached that of the general population, suggesting that better provision of primary medical care may effectively reduce premature mortality among persons with bipolar disorder.read more
Citations
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Risk of cardiometabolic diseases among siblings of patients with bipolar disorder.
Wen Yen Tsao,Ju Wei Hsu,Kai Lin Huang,Ya Mei Bai,Tung Ping Su,Cheng Ta Li,Shih-Jen Tsai,Wei Chen Lin,Tzeng Ji Chen,Tai Long Pan,Tai Long Pan,Tai Long Pan,Mu Hong Chen,Mu Hong Chen +13 more
TL;DR: Unaffected siblings of bipolar patients, particularly brothers, had a higher prevalence of dyslipidemia and ischemic stroke compared with the controls, which suggests the familial association between cardiometabolic diseases and bipolar disorder.
Journal ArticleDOI
Pain intensity, depressive symptoms, and functional limitations among older adults with serious mental illness.
Jessica M. Brooks,Courtney A. Polenick,William C. Bryson,John A. Naslund,Brenna N. Renn,Nicole M. Orzechowski,Margaret Almeida,Stephen J. Bartels +7 more
TL;DR: These findings demonstrate that pain and depressive symptoms may be linked to functional limitations and Clinicians and researchers in the mental health field should better address pain-related activity interference among older adults with SMI, especially among those with higher pain intensity and elevated depressive symptoms.
Journal ArticleDOI
Seasonal pattern in bipolar disorders and cardio-vascular risk factors: A study from the FACE-BD cohort
Pierre A. Geoffroy,Ophélia Godin,Diane Mahee,Chantal Henry,Valerie Aubin,Jean-Michel Azorin,Thierry Bougerol,Philippe Courtet,Sébastien Gard,Jean-Pierre Kahn,Christine Passerieux,Marion Leboyer,Frank Bellivier,Bruno Etain +13 more
TL;DR: Patients with SP appeared more vulnerable to overweight/obesity and presented with higher levels of MetS subcomponents although these parameters were mainly in the normal range, and all patients with BD should benefit from early screening and targeted management of cardio-vascular risk factors.
Journal ArticleDOI
Diabetes mellitus risk for 102 drugs and drug combinations used in patients with bipolar disorder.
Anastasiya Nestsiarovich,Berit Kerner,Aurélien J. Mazurie,Daniel C. Cannon,Nathaniel G. Hurwitz,Yiliang Zhu,Stuart J. Nelson,Tudor I. Oprea,Annette S. Crisanti,Mauricio Tohen,Douglas J Perkins,Christophe G. Lambert +11 more
TL;DR: There is an increased risk of diabetes mellitus associated with antipsychotic and psychotropic polypharmacy use in bipolar disorder and the evidence of a lower-than-baseline risk of DM with lamotrigine, oxcarbazepine, lithium, and bupropion monotherapy is investigated.
Journal ArticleDOI
Chronic obstructive pulmonary disease associated with increased risk of bipolar disorder.
Vincent Yi Fong Su,Li Yu Hu,Chiu Mei Yeh,Huey-Ling Chiang,Cheng Che Shen,Cheng Che Shen,Kun Ta Chou,Tzeng Ji Chen,Tzeng Ji Chen,Ti Lu,Cheng Hwai Tzeng,Chia Jen Liu,Chia Jen Liu +12 more
TL;DR: The study results indicate that COPD may be an independent risk factor for the development of bipolar Disorder and the regular use of SABAs might increase the risk of bipolar disorder in COPD patients.
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