Comorbidities and Mortality in Bipolar Disorder A Swedish National Cohort Study
Casey Crump,Kristina Sundquist,Kristina Sundquist,Marilyn A. Winkleby,Jan Sundquist,Jan Sundquist +5 more
TLDR
Patients with bipolar disorder had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries, and suicide for both women and men and cancer for women only.Abstract:
Importance Bipolar disorder is associated with premature mortality, but the specific causes and underlying pathways are unclear. Objective To examine the physical health effects of bipolar disorder using outpatient and inpatient data for a national population. Design, Setting, and Participants National cohort study of 6 587 036 Swedish adults, including 6618 with bipolar disorder. Main Outcomes and Measures Physical comorbidities diagnosed in any outpatient or inpatient setting nationwide and mortality (January 1, 2003, through December 31, 2009). Results Women and men with bipolar disorder died 9.0 and 8.5 years earlier on average than the rest of the population, respectively. All-cause mortality was increased 2-fold among women (adjusted hazard ratio [aHR], 2.34; 95% CI, 2.16-2.53) and men (aHR, 2.03; 95% CI, 1.85-2.23) with bipolar disorder, compared with the rest of the population. Patients with bipolar disorder had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries, and suicide for both women and men and cancer for women only. Suicide risk was 10-fold among women (aHR, 10.37; 95% CI, 7.36-14.60) and 8-fold among men (aHR, 8.09; 95% CI, 5.98-10.95) with bipolar disorder, compared with the rest of the population. Substance use disorders contributed only modestly to these findings. The association between bipolar disorder and mortality from chronic diseases (ischemic heart disease, diabetes, COPD, or cancer) was weaker among persons with a prior diagnosis of these conditions (aHR, 1.40; 95% CI, 1.26-1.56) than among those without a prior diagnosis (aHR, 2.38; 95% CI, 1.95-2.90; P interaction = .01). Conclusions and Relevance In this large national cohort study, patients with bipolar disorder died prematurely from multiple causes, including cardiovascular disease, diabetes, COPD, influenza or pneumonia, unintentional injuries, and suicide. However, chronic disease mortality among those with more timely medical diagnosis approached that of the general population, suggesting that better provision of primary medical care may effectively reduce premature mortality among persons with bipolar disorder.read more
Citations
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Journal ArticleDOI
Medical Comorbidities in Bipolar Disorder.
TL;DR: An updated narrative review of original research articles and meta-analyses published in English language journals from January 2013 to May 2017 focusing on general medical comorbidity in bipolar disorder, including the added risks of iatrogenic factors relevant to the treatment of BD highlights the association between BD and a variety of medical disorders.
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Severe mental illness is associated with increased mortality and severe course of COVID-19.
C A Barcella,Christoffer Polcwiartek,G H Mohr,Gethin Hodges,K. B. Sondergaard,Casper Niels Bang,Mikkel Porsborg Andersen,Emil L. Fosbøl,Lars Køber,Morten Schou,Christian Torp-Pedersen,Lars Vedel Kessing,Lars Vedel Kessing,Gunnar Gislason,Gunnar Gislason,Kristian Kragholm +15 more
TL;DR: In this article, a multivariable cox regression was used to calculate 30-day absolute risk and average risk ratio (ARR) for the composite end point of death from any cause and severe COVID-19 associated with psychiatric disorders, defined using both hospital diagnoses and redemption of psychotropic drugs.
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Impaired glucose metabolism moderates the course of illness in bipolar disorder
Rodrigo B. Mansur,Rodrigo B. Mansur,Lucas B. Rizzo,Lucas B. Rizzo,Camila M. Santos,Elson Asevedo,Graccielle R. Cunha,Mariane N. Noto,Mariana Pedrini,Maiara Zeni,Quirino Cordeiro,Roger S. McIntyre,Elisa Brietzke +12 more
TL;DR: Comorbid IGM may be a key moderator of illness progression in BD, with the correlation between lifetime mood episodes and frequency of episodes being significantly greater in the IGM subgroup.
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Anti-TNF-α Compounds as a Treatment for Depression
Sarit Uzzan,Abed N. Azab +1 more
TL;DR: In this paper, a mini-review summarizes the results of studies that examined the mood-modulating effects of anti-TNF-α drugs for mood disorders such as major depression and bipolar disorder.
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The Impact of General Medical Conditions in Obsessive-Compulsive Disorder
TL;DR: The presence of a GMC was significantly associated with female gender, older age, duration of untreated illness (DUI), and absence of physical activity, and the association between the presence of GMCs and demographic/clinical variables of OCD was investigated.
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