Comparing the diagnostic accuracy of point-of-care lateral flow antigen testing for SARS-CoV-2 with RT-PCR in primary care (REAP-2).
Werner Leber,Oliver Lammel,Andrea Siebenhofer,Andrea Siebenhofer,Monika Redlberger-Fritz,Jasmina Panovska-Griffiths,Jasmina Panovska-Griffiths,Thomas Czypionka +7 more
TLDR
Czypionka et al. as mentioned in this paper showed that lateral flow testing (LFT) is an accurate alternative to RT-PCR testing in primary care in COVID-19 patients.About:
This article is published in EClinicalMedicine.The article was published on 2021-07-13 and is currently open access. It has received 25 citations till now. The article focuses on the topics: European union.read more
Citations
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Journal ArticleDOI
Diagnostics for COVID-19: moving from pandemic response to control
TL;DR: Antigen rapid detection tests have been used as a public health tool for screening individuals at enhanced risk of infection, to protect people who are clinically vulnerable, to ensure safe travel and the resumption of schooling and social activities, and to enable economic recovery as mentioned in this paper .
Journal ArticleDOI
Daily testing for contacts of individuals with SARS-CoV-2 infection and attendance and SARS-CoV-2 transmission in English secondary schools and colleges: an open-label, cluster-randomised trial.
Bernadette C. Young,David W Eyre,David W Eyre,Saroj Kendrick,Christopher J. White,Sylvester Smith,George Beveridge,Toby Nonnenmacher,Fegor Ichofu,Joseph Hillier,Sarah Oakley,Ian Diamond,Emma Rourke,Fiona Dawe,Ieuan Day,Lisa Davies,Paul Staite,Andrea Lacey,James McCrae,Ffion Jones,Joseph Kelly,Urszula Bankiewicz,Sarah Tunkel,Richard Ovens,David Chapman,Vineta Bhalla,Peter Marks,Nick Hicks,Nick Hicks,Tom Fowler,Susan Hopkins,Lucy Yardley,Lucy Yardley,Tim E. A. Peto,Tim E. A. Peto +34 more
TL;DR: In this article, the authors did an open-label, cluster-randomised, controlled trial in secondary schools and further education colleges in England, where schools were randomly assigned to self-isolation of school-based COVID-19 contacts for 10 days (control) or to voluntary daily lateral flow device (LFD) testing for 7 days with LFD-negative contacts remaining at school (intervention).
Journal ArticleDOI
SARS-CoV-2 viral load and shedding kinetics
TL;DR: In this article , the authors studied the factors and mechanisms that influence infectious virus shedding and the period during which individuals infected with SARS-CoV-2 are contagious, and proposed a diagnostic tool to demonstrate the presence of infectious virus from routine diagnostic specimens.
Journal ArticleDOI
Biotechnological Perspectives to Combat the COVID-19 Pandemic: Precise Diagnostics and Inevitable Vaccine Paradigms
TL;DR: In conclusion, the insights of this review would facilitate the development of more likely diagnostics and ideal vaccines for the global control of COVID-19.
Real-world deployment of lateral flow SARS-CoV-2 antigen detection in the emergency department to provide rapid, accurate and safe diagnosis of COVID-19.
Blair Merrick,Blair Merrick,M. Noronha,Rahul Batra,Rahul Batra,Sam Douthwaite,Sam Douthwaite,Gaia Nebbia,Gaia Nebbia,Luke B Snell,Luke B Snell,Suzanne Pickering,Rui Pedro Galão,J. Whitfield,A. Jahangeer,R. Gunawardena,T. Godfrey,R. Laifa,K. Webber,P. R. Cliff,E. Cunningham,Stuart J. D. Neil,H. Gettings,Jonathan D. Edgeworth,Jonathan D. Edgeworth,H.L. Harrison +25 more
TL;DR: In this paper, a review of LFD test results, laboratory and POC-RT-PCR results and ED performance metrics during a two-week high SARS-CoV-2 prevalence period followed by several months of falling prevalence is presented.
References
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STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies
Patrick M.M. Bossuyt,Johannes B. Reitsma,David E. Bruns,Constantine Gatsonis,Paul Glasziou,Les Irwig,Jeroen G. Lijmer,David Moher,David Moher,Drummond Rennie,Henrica C.W. de Vet,Herbert Y. Kressel,Nader Rifai,Robert M. Golub,Douglas G. Altman,Lotty Hooft,Daniël A. Korevaar,Jérémie F. Cohen,Jérémie F. Cohen +18 more
TL;DR: STARD 2015 is presented, an updated list of 30 essential items that should be included in every report of a diagnostic accuracy study, which incorporates recent evidence about sources of bias and variability in diagnostic accuracy.
Journal ArticleDOI
False Negative Tests for SARS-CoV-2 Infection - Challenges and Implications.
TL;DR: Diagnostic testing for SARS-CoV-2 will help in safely reopening the country, but only if tests are highly accurate, experts say.
Journal ArticleDOI
Interpreting a covid-19 test result.
TL;DR: The availability of the complete genome of covid-19 early in the epidemic facilitated development of tests to detect viral RNA, which enables infected individuals to be identified and isolated to reduce spread and provides knowledge of regional and national rates of infection to inform public health interventions.
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False-positive COVID-19 results: hidden problems and costs.
TL;DR: www.thelancet.com/respiratory Vol 8 December 202 and www.clinicaltrials.gov/cases/cases-of-controlling-children-with-disorders/
Journal ArticleDOI
Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centres.
Eliseo Albert,Ignacio Torres,Felipe Bueno,Dixie Huntley,Estefanía Molla,Miguel Ángel Fernández-Fuentes,Mireia Martínez,Sandrine Poujois,Lorena Forqué,Arantxa Valdivia,Carlos Solano de la Asunción,Josep Ferrer,Javier Colomina,David Navarro +13 more
TL;DR: The data suggested that patients with RT-PCR-proven COVID-19 testing negative by RAD are unlikely to be infectious, and the Panbio™ CO VID-19 Ag Rapid Test Device performed well as a POCT for early diagnosis in primary healthcare centers.
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