Complement activation and protein adsorption by carbon nanotubes.
Carolina Salvador-Morales,Emmanuel Flahaut,Edith Sim,Jeremy Sloan,Malcolm L. H. Green,Robert B. Sim +5 more
Reads0
Chats0
TLDR
It is reported for the first time that carbon nanotubes activate human complement via both classical and alternative pathways, and it is concluded that complement activation by nanot tubes is consistent with reported adjuvant effects, and might also in various circumstances promote damaging effects of excessive complement activation.About:
This article is published in Molecular Immunology.The article was published on 2006-02-01 and is currently open access. It has received 407 citations till now. The article focuses on the topics: Classical complement pathway & Complement system.read more
Citations
More filters
Journal ArticleDOI
Nanoparticle therapeutics: an emerging treatment modality for cancer
TL;DR: The features of nanoparticle therapeutics that distinguish them from previous anticancer therapies are highlighted, and how these features provide the potential for therapeutic effects that are not achievable with other modalities are described.
Journal ArticleDOI
Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles.
Tommy Cedervall,Iseult Lynch,Stina Lindman,Tord Berggård,Eva Thulin,Hanna Nilsson,Kenneth A. Dawson,Sara Linse +7 more
TL;DR: The rates of protein association and dissociation are determined using surface plasmon resonance technology with nanoparticles that are thiol-linked to gold, and through size exclusion chromatography of protein–nanoparticle mixtures, and this method is developed into a systematic methodology to isolate nanoparticle-associated proteins.
Journal ArticleDOI
Biomolecular coronas provide the biological identity of nanosized materials
TL;DR: The basic concept of the nanoparticle corona is reviewed and its structure and composition is highlighted, and how the properties of the corona may be linked to its biological impacts are highlighted.
Journal ArticleDOI
Applications of carbon nanotubes in drug delivery
TL;DR: Carbon nanotubes have emerged as a new alternative and efficient tool for transporting and translocating therapeutic molecules and hold great potential in the field of nanobiotechnology and nanomedicine.
Journal ArticleDOI
Immunological properties of engineered nanomaterials.
TL;DR: Research shows that nanoparticles can stimulate and/or suppress the immune responses, and that their compatibility with the immune system is largely determined by their surface chemistry, and modifying these factors can significantly reduce the immunotoxicity of nanoparticles and make them useful platforms for drug delivery.
References
More filters
Journal ArticleDOI
Large-scale production of single-walled carbon nanotubes by the electric-arc technique
Catherine Journet,Wolfgang K. Maser,Patrick Bernier,A. Loiseau,M. Lamy de la Chapelle,Serge Lefrant,Philippe Deniard,R. S. Lee,John E. Fischer +8 more
TL;DR: In this article, it was shown that the growth mechanism for SWNTs must be independent of the details of the technique used to make them, and that the ready availability of large amounts of SWNT can make them much more accessible for further study.
Journal ArticleDOI
Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
TL;DR: Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.
Journal ArticleDOI
Catalytic growth of single-walled manotubes by laser vaporization
TL;DR: In this paper, a model for carbon nanotubes growth was presented for both the present case and the arc in which the metal particle size is limited due to the concurrent carbon condensation.
Journal ArticleDOI
Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors
Robert Chen,Sarunya Bangsaruntip,Katerina A. Drouvalakis,Nadine Wong Shi Kam,Moonsub Shim,Yiming Li,Woong Kim,Paul J. Utz,Hongjie Dai +8 more
TL;DR: An exploration of single-walled carbon nanotubes is presented as a platform for investigating surface–protein and protein–protein binding and developing highly specific electronic biomolecule detectors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.
Journal ArticleDOI
Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells.
TL;DR: In this paper, the interactions between various functionalized carbon nanotubes and several types of human cancer cells are explored. And they have shown that these can be derivatized in a way that enables attachment of small molecules and of proteins, the latter through a novel noncovalent association.
Related Papers (5)
Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
Anna A. Shvedova,Elena R. Kisin,Robert R. Mercer,Ashley R. Murray,Victor J. Johnson,Alla I. Potapovich,Yulia Y. Tyurina,Olga Gorelik,Sevaram Arepalli,Diane Schwegler-Berry,Ann F. Hubbs,James M. Antonini,Douglas E. Evans,Bon Ki Ku,Dawn Ramsey,Andrew D. Maynard,Valerian E. Kagan,Vincent Castranova,Vincent Castranova,Paul A. Baron +19 more