Journal ArticleDOI
Complementarity between Rous sarcoma virus (RSV) RNA and the in vitro-synthesized DNA of the virus-associated DNA polymerase.
Peter H. Duesberg,E. Canaani +1 more
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This article is published in Virology.The article was published on 1970-11-01. It has received 96 citations till now. The article focuses on the topics: Hepatitis B virus DNA polymerase & RNA-dependent RNA polymerase.read more
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Hybridization of Rous sarcoma virus deoxyribonucleic acid polymerase product and ribonucleic acids from chicken and rat cells infected with Rous sarcoma virus.
John M. Coffin,Howard M. Temin +1 more
TL;DR: Rous sarcoma virus (RSV)-specific ribonucleic acid (RNA) in virus-producing chicken cells and non-virus-producing rat cells infected with RSV was studied by hybridization with the endogenous deoxyribonuclear acid (DNA) product of the RSV virion DNA polymerase system.
Journal ArticleDOI
Mechanism of stimulation of murine type-C RNA tumor virus production by glucocorticoids: post-transcriptional effects.
TL;DR: The results of the time course studies, and the cordycepin, interferon, and hybridization experiments, suggest that the effect of dexamethasone on type-C virus production in this system is post-transcriptional.
Journal ArticleDOI
Ribonuclease-Sensitive Deoxyribonucleic Acid Polymerase Activity in Uninfected Rat Cells and Rat Cells Infected with Rous Sarcoma Virus
John M. Coffin,Howard M. Temin +1 more
TL;DR: The endogenous template for the DNA polymerase activity in high-speed pellet fractions from R(B77) cells was not related to B77 virus RNA or to RNA of a rat C-type virus and hybridized to a small extent with RNA from the same fraction and to a similar extent withRNA from uninfected rat cells.
Journal ArticleDOI
In vitro transcription of DNA from the 70S RNA of Rous sarcoma virus: identification and characterization of various size classes of DNA transcripts.
M S Collett,A J Faras +1 more
TL;DR: The identification of large DNA chains in the DNA product synthesized in vitro by the avian oncornavirus RNA-directed DNA polymerase provides an explanation for the paradox that exists between the limited number of primer sites per 70S RNA genome, the small size of the bulk of theDNA product, and the extent of the Rous sarcoma virus genome represented by the DNA products.
Journal ArticleDOI
Deoxyribonucleic Acid Polymerase of Rous Sarcoma Virus: Reaction Conditions and Analysis of the Reaction Product Nucleic Acids
D. H. L. Bishop,D. H. L. Bishop,Ruth Ruprecht,Ruth Ruprecht,Robert W. Simpson,Robert W. Simpson,S. Spiegelman,S. Spiegelman +7 more
TL;DR: It was concluded that analyses of the product of reverse transcriptase reactions should not only refer to the template RNA and product DNA species, but also be performed with virus or viral RNA which do not have or obtain nicks in the 60S RNA.
References
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Journal ArticleDOI
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses
TL;DR: Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template, apparently the classical process of information transfer from DNA to RNA can be inverted.
Journal ArticleDOI
RNA-dependent DNA polymerase in virions of Rous sarcoma virus.
Howard M. Temin,Satoshi Mizutani +1 more
TL;DR: Viral RNA-dependent DNA Polymerase: RNA- dependent DNA polymerase in Virions of Rous Sarcoma Virus and its role in cell reprograming is studied.
Journal ArticleDOI
Formation and properties of RNA-DNA complexes*
A.P. Nygaard,B.D. Hall +1 more
TL;DR: The rate of formation of complexes between T2 RNA and T2 DNA has been measured at various salt concentrations and temperatures and the resistance to RNase increased with increasing salt concentration but was not complete under any condition tested.
Journal ArticleDOI
Characterization of the products of DNA-directed DNA polymerases in oncogenic RNA viruses.
TL;DR: Several RNA tumour viruses contain an enzyme that synthesizes a DNA–RNA hybrid using the single stranded viral RNA as template, and hybridization experiments confirm that the DNA strand is complementary to the viral RNA.
Related Papers (5)
RNA-dependent DNA polymerase in virions of Rous sarcoma virus.
Howard M. Temin,Satoshi Mizutani +1 more