Open AccessJournal Article
Contribution to the study of the toxoplasmosis epidemiology. Serologic survey among the indians of the upper Xingu River, Central Brazil.
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This article is published in Revista Do Instituto De Medicina Tropical De Sao Paulo.The article was published on 1970-03-01 and is currently open access. It has received 100 citations till now.read more
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Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology.
TL;DR: Prevalence, clinical spectrum, molecular epidemiology, and control of T. gondii in humans and animals in Brazil are reviewed to help biologists, public health workers, veterinarians, and physicians understand the severity of clinical toxoplasmosis in Brazilian children.
Journal ArticleDOI
Infectious diseases in primitive societies
TL;DR: The suggestion is made that the latter diseases could not perpetuate themselves before the advent of advanced cultures and did not exert selective pressures on the human genetic constitution until relatively recently.
Journal ArticleDOI
Searching for New Chemotherapies for Tropical Diseases: Ruthenium–Clotrimazole Complexes Display High in Vitro Activity against Leishmania major and Trypanosoma cruzi and Low Toxicity toward Normal Mammalian Cells
Alberto Martínez,Teresia A. Carreon,Eva Iniguez,Atilio Anzellotti,Antonio Sánchez,Marina Tyan,Aaron Sattler,Linda J. Herrera,Rosa A. Maldonado,Roberto A. Sánchez-Delgado +9 more
TL;DR: Eight new ruthenium complexes of clotrimazole (CTZ) with high antiparasitic activity have been synthesized, resulting in nanomolar and low micromolar lethal doses and therapeutic indexes of 500 and 75, respectively.
Journal ArticleDOI
Characterization of toxoplasma gondii isolates in free-range chickens from amazon, brazil
Jitender P. Dubey,Solange Maria Gennari,Marcelo Bahia Labruna,Luís Marcelo Aranha Camargo,M.C.B. Vianna,Paula L. Marcet,Tovi Lehmann +6 more
TL;DR: Toxoplasma gondii isolates by polymorphisms at the SAG2 locus indicated that 14 were type I, and 10 were type III; the absence of type II strains from Brazil was confirmed and Fifty percent of the infected mice died of toxoplasmosis, irrespective of the genotype.
Journal ArticleDOI
GPIomics: global analysis of glycosylphosphatidylinositol-anchored molecules of Trypanosoma cruzi
Ernesto S. Nakayasu,Dmitry V. Yashunsky,Lilian L. Nohara,Ana Claudia Torrecilhas,Andrei V. Nikolaev,Igor C. Almeida +5 more
TL;DR: A fast, simple, and highly sensitive method that uses liquid chromatography‐tandem mass spectrometry (LC‐MSn) for the first large‐scale analysis of GPI‐anchored molecules (i.e., the GPIome) of a eukaryote, Trypanosoma cruzi, the etiologic agent of Chagas disease is developed.
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