Journal ArticleDOI
Conversion of biomembrane-produced energy into electric form. I. Submitochondrial particles.
L.L. Grinius,L.L. Grinius,Audrius Jasaitis,Audrius Jasaitis,Yu.P. Kadziauskas,Yu.P. Kadziauskas,Liberman Ea,Liberman Ea,Vladimir P. Skulachev,Vladimir P. Skulachev,V.P. Topali,V.P. Topali,Tsofina Lm,Tsofina Lm,Vladimirova Ma,Vladimirova Ma +15 more
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TLDR
It was concluded that a mechanism for ion accumulation in submitochondrial particles is specific for the sign of the charge but not for other features of the penetrating compounds.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1970-08-04. It has received 297 citations till now. The article focuses on the topics: Submitochondrial particle & Energy source.read more
Citations
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Journal ArticleDOI
Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy.
TL;DR: Permeant cationic fluorescent probes are shown to be selectively accumulated by the mitochondria of living cells and application of such potential-dependent probes in conjunction with fluorescence microscopy allows the monitoring of mitochondrial membrane potential in individual living cells.
Journal ArticleDOI
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
Jacek Zielonka,Joy Joseph,Adam Sikora,Micael Hardy,Olivier Ouari,Jeannette Vasquez-Vivar,Gang Cheng,Marcos Lopez,Balaraman Kalyanaraman +8 more
TL;DR: The physicochemical basis for mitochondrial accumulation of lipophilic cations, synthetic chemistry strategies to target compounds to mitochondria, mitochondrial probes, and sensors, and examples of mitochondrial targeting of bioactive compounds are described.
Journal ArticleDOI
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
Victoria J. Adlam,Joanne C. Harrison,Carolyn M. Porteous,Andrew M. James,Robin A.J. Smith,Michael P. Murphy,Ivan A. Sammut +6 more
TL;DR: Developing mitochondria‐targeted antioxidants, typified by MitoQ, which comprises a lipophilic triphenylphosphonium (TPP) cation covalently attached to a ubiquinol antioxidant, significantly decreased heart dysfunction, cell death, and mitochondrial damage after ischemia‐reperfusion injury.
Book ChapterDOI
Optical measurement of membrane potential.
TL;DR: The use of redistribution signals, which are slower, and thus more likely to represent to secondary effects of changes in membrane potential, and require permeant dyes with access to the internal millieu, may be more hazardous than the use of either fast or intrinsic signals.
Journal ArticleDOI
Conservation and transformation of energy by bacterial membranes.
TL;DR: Energy Transductions in Mitochondria and the Role of the Membrane in Motility, Bacteriocins and the Energized State are studied.
References
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Journal ArticleDOI
Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids
TL;DR: It is found that as the surface charge of the lipid lamellae is increased, the amount of cation per μmle of lipid increases, and the phospholipid liquid crystalline structures appear to “bind” or “capture” cations.
Journal ArticleDOI
Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism
TL;DR: Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism is described.
Journal ArticleDOI
Partial resolution of the enzymes catalyzing oxidative phosphorylation. I. Purification and properties of soluble dinitrophenol-stimulated adenosine triphosphatase.
Journal ArticleDOI
Methods for the formation of single bimolecular lipid membranes in aqueous solution
Journal ArticleDOI
Studies on the electron transfer system. IV. The electron transfer particle.
TL;DR: The preparation and properties of an electron transfer particle (ETP) obtained from beef heart mitochondria are described and the significance of the fact of the constant composition of ETP for the dynamics of electron transport is discussed.
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