Journal ArticleDOI
Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment.
TLDR
The mechanism of cou marin-induced tumour formation in rodents is associated with metabolism-mediated, toxicity and it is concluded that exposure to coumarin from food and/or cosmetic products poses no health risk to humans.About:
This article is published in Food and Chemical Toxicology.The article was published on 1999-04-01. It has received 462 citations till now. The article focuses on the topics: Toxicity.read more
Citations
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Coumarin-Based Small-Molecule Fluorescent Chemosensors.
Duxia Cao,Zhiqiang Liu,Peter Verwilst,Seyoung Koo,Paramesh Jangjili,Jong Seung Kim,Weiying Lin,Weiying Lin +7 more
TL;DR: This comprehensive and critical review of coumarin-based small-molecule fluorescent chemosensors during the period of 2012-2018 may facilitate the development of more powerful fluorescent chemOSensors for broad and exciting applications in the future.
Journal Article
The Cap ‘n’ Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and Inducible Expression of Intestinal Detoxification and Glutathione Biosynthetic Enzymes
Michael McMahon,Ken Itoh,Masayuki Yamamoto,Simon A. Chanas,Colin J. Henderson,Lesley I. McLellan,C. Roland Wolf,Christophe Cavin,John D. Hayes +8 more
TL;DR: In the small intestine, the constitutive level of NQO1 is lower in the Nrf2-/- mouse, and immunoblotting showed that induction of the oxidoreductase was substantially diminished in the mutant mouse.
Journal ArticleDOI
Review on natural coumarin lead compounds for their pharmacological activity
TL;DR: In view of the established low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further.
Journal ArticleDOI
Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer
Aoife Lacy,Richard O'Kennedy +1 more
TL;DR: These studies suggest that both genistein and esculetin exerted the most potent inhibitory effect on cell growth in comparison to the other two compounds, which may lead to its use in cancer therapy.
Journal ArticleDOI
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
TL;DR: An overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations.
References
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Journal ArticleDOI
P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
David R. Nelson,Luc Koymans,Tetsuya Kamataki,John J. Stegeman,Ren Feyereisen,David J. Waxman,Michael R. Waterman,Osamu Gotoh,Minor J. Coon,Ron W. Estabrook,Irwin C. Gunsalus,Daniel W. Nebert +11 more
TL;DR: This revision supersedes the four previous updates in which a nomenclature system, based on divergent evolution of the P450 superfamily has been described and is similar to that proposed in the previous updates.
Journal Article
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
TL;DR: The results presented in this study provide useful information for the study of drug biotransformation in humans and for the basis of drug toxicities, carcinogenesis and teratogenesis.
Journal ArticleDOI
The human hepatic cytochromes P450 involved in drug metabolism.
TL;DR: The purpose of this review is to compare and contrast the human P 450s involved in drug metabolism with their related forms in the rat and other experimental species with respect to their relative levels of the various P450s and their metabolic capabilities.
Book
The Condensed chemical dictionary
TL;DR: The Condensed Chemical Dictionary as discussed by the authors, The Condensed chemical dictionary, and The Condensated Chemical Dictionary (CDD) [1]... ].., [2]
Journal ArticleDOI
Salmonella mutagenicity test results for 250 chemicals
TL;DR: This publication is a presentation of Salmonella testing results on 250 coded chemicals, encompassing 370 tests, designed both to summarize the results in the text and to present the data so that the reader has the opportunity of performing an independent evaluation of the data.
Related Papers (5)
Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential
J. R. S. Hoult,Miguel Payá +1 more
Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer
Aoife Lacy,Richard O'Kennedy +1 more