Journal ArticleDOI
Cross-linking in collagen and elastin
TLDR
Allysine and Hydroxyallysine Pathways Pathways, Allysine-Hydroxypyridinium Residues, and Methods for Analysis: Alternative M echanisms and Methods are presented.Abstract:
PERSPECTIVES AND SUMMARy 717 LYSYL OXIDASE 719 COLLAGEN 720 Allysine and Hydroxyallysine Pathways 720 Hydroxypyridinium Residues... ... 724 Molecular Sites 730 Basement Membranes 733 Methods oj Analysis 734 Alternative M echanisms ..... ... 734read more
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Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Kandice R. Levental,Hongmei Yu,Laura Kass,Johnathon N. Lakins,Mikala Egeblad,Janine T. Erler,Sheri F. T. Fong,Katalin Csiszar,Amato J. Giaccia,Wolfgang Weninger,Mitsuo Yamauchi,David L. Gasser,Valerie M. Weaver +12 more
TL;DR: Reduction of lysyl oxidase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and PI3K activity, impeded malignancy, and lowered tumor incidence, and data show how collagenCrosslinking can modulate tissue fibrosis and stiffness to force focal adhesion, growth factor signaling and breast malignancies.
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Collagen Structure and Stability
TL;DR: The fibrillar structure of type I collagen-the prototypical collagen fibril-has been revealed in detail and will guide further development of artificial collagenous materials for biomedicine and nanotechnology.
Journal ArticleDOI
Nature’s hierarchical materials
Peter Fratzl,Richard Weinkamer +1 more
TL;DR: In this paper, the basic principles involved in designing hierarchical biological materials, such as cellular and composite architectures, adapative growth and as well as remodeling, are discussed, and examples that are found to utilize these strategies include wood, bone, tendon, and glass sponges.
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Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading
TL;DR: Full understanding of these physiological processes will provide the physiological basis for understanding of tissue overloading and injury seen in both tendons and muscle with repetitive work and leisure time physical activity.
Journal ArticleDOI
Quantitative optical spectroscopy for tissue diagnosis
TL;DR: This review describes optical interactions pursued for biomedical applications (fluorescence, fluorescence lifetime, phosphorescence, and Raman from cells, cultures, and tissues) and provides a descriptive framework for light interaction based upon tissue absorption and scattering properties.