Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer.
Wenrui Wang,Tiantian Chen,Henan Xu,Baihui Ren,Xiaodan Cheng,Rongrong Qi,Haibo Liu,Yueyue Wang,Lei Yan,Sulian Chen,Qingling Yang,Changjie Chen +11 more
TLDR
The results suggested that Cur-SLNs could be a potential useful chemotherapeutic formulation for breast cancer therapy.Abstract:
Curcumin (Cur) has been widely used in medicine, due to its antibacterial, anti-inflammatory, antioxidant, and antitumor effects. However, its clinic application is limited by its instability and poor solubility. In the present wok, curcumin was loaded into solid lipid nanoparticles (SLNs), in order to improve the therapeutic efficacy for breast cancer. The results measured using transmission electron microscopy (TEM) indicated that Cur-SLNs have a well-defined spherical shape; the size was about 40 nm with a negative surface charge. The drug loading and encapsulation efficiency in SLNs reached 23.38% and 72.47%, respectively. The Cur-SLNs showed a stronger cytotoxicity against SKBR3 cells. In vitro cellular uptake study demonstrated a high uptake efficiency of the Cur-SLNs by SKBR3 cells. Moreover, Cur-SLNs induced higher apoptosis in SKBR3 cells, compared to cells treated by free drug. In addition, Western blot analysis revealed that Cur-SLNs could promote the ratio of Bax/Bcl-2, but decreased the expression of cyclin D1 and CDK4. These results suggested that Cur-SLNs could be a potential useful chemotherapeutic formulation for breast cancer therapy.read more
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Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery.
Nuzhat Zahin,Raihanatul Anwar,Devesh Tewari,Md. Tanvir Kabir,Amin Sajid,Bijo Mathew,Md. Sahab Uddin,Lotfi Aleya,Mohamed M. Abdel-Daim +8 more
TL;DR: This review focuses on the detailed profile of NPs, its impact on biology and medicine, and their commercialization prospects.
Journal ArticleDOI
Nanocurcumin: A Promising Candidate for Therapeutic Applications.
TL;DR: This review discusses the different curcumin nanoformulation and nanocurcumin implications for different therapeutic applications as well as the status of ongoing clinical trials and patents, and discusses the research gap and future research directions needed to proposeCurcumin as a promising therapeutic candidate.
Journal ArticleDOI
Nanodelivery of Natural Antioxidants: An Anti-aging Perspective.
TL;DR: The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.
Journal ArticleDOI
Effects of Quercetin-Loaded Nanoparticles on MCF-7 Human Breast Cancer Cells
Firoozeh Niazvand,Mahmoud Orazizadeh,Layasadat Khorsandi,Mohammadreza Abbaspour,Esrafil Mansouri,Ali Khodadadi +5 more
TL;DR: SLN significantly enhanced the toxic effect of QT against human breast cancer cells and induced a significant decrease in the viability and proliferation of MCF-7 cells, compared to the free QT.
Journal ArticleDOI
Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers
Md. Tanvir Kabir,Md. Habibur Rahman,Rokeya Akter,Tapan Behl,Deepak Kaushik,Vineet Mittal,Parijat Pandey,Muhammad Furqan Akhtar,Ammara Saleem,Ghadeer M. Albadrani,Mohamed Kamel,Shaden A. M. Khalifa,Hesham R. El-Seedi,Mohamed M. Abdel-Daim +13 more
TL;DR: Wang et al. as discussed by the authors summarized the anticancer activity of CUR against several cancers, for example, gastrointestinal, head and neck, brain, pancreatic, colorectal, breast, and prostate cancers.
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TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
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Selective degradation of mitochondria by mitophagy.
TL;DR: The term mitophagy is used to refer to mitochondrial degradation by autophagy, and the possible role of the mitochondrial permeability transition in mitophagic delivery to lysosomes is the major degradative pathway in mitochondrial turnover.
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p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
TL;DR: It is confirmed that p53 can mediate arrest at this stage, as well as in G1, and that irreversible arrest must involve processes other than or in addition to the interaction of p53-induced p21/WAF1 with G1 and G2 cyclin-dependent kinases.
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The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery.
Claudia Corbo,Roberto Molinaro,Alessandro Parodi,Naama E. Toledano Furman,Francesco Salvatore,Ennio Tasciotti +5 more
TL;DR: A survey of recent findings on the NP-PC interactions is provided and how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers is discussed.
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Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance
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