Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer.
Wenrui Wang,Tiantian Chen,Henan Xu,Baihui Ren,Xiaodan Cheng,Rongrong Qi,Haibo Liu,Yueyue Wang,Lei Yan,Sulian Chen,Qingling Yang,Changjie Chen +11 more
TLDR
The results suggested that Cur-SLNs could be a potential useful chemotherapeutic formulation for breast cancer therapy.Abstract:
Curcumin (Cur) has been widely used in medicine, due to its antibacterial, anti-inflammatory, antioxidant, and antitumor effects. However, its clinic application is limited by its instability and poor solubility. In the present wok, curcumin was loaded into solid lipid nanoparticles (SLNs), in order to improve the therapeutic efficacy for breast cancer. The results measured using transmission electron microscopy (TEM) indicated that Cur-SLNs have a well-defined spherical shape; the size was about 40 nm with a negative surface charge. The drug loading and encapsulation efficiency in SLNs reached 23.38% and 72.47%, respectively. The Cur-SLNs showed a stronger cytotoxicity against SKBR3 cells. In vitro cellular uptake study demonstrated a high uptake efficiency of the Cur-SLNs by SKBR3 cells. Moreover, Cur-SLNs induced higher apoptosis in SKBR3 cells, compared to cells treated by free drug. In addition, Western blot analysis revealed that Cur-SLNs could promote the ratio of Bax/Bcl-2, but decreased the expression of cyclin D1 and CDK4. These results suggested that Cur-SLNs could be a potential useful chemotherapeutic formulation for breast cancer therapy.read more
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The loaded Ferula assa-foetida seed essential oil in Solid lipid nanoparticles (FSEO-SLN) as the strong apoptosis inducer agents in human NTERA-2 embryocarcinoma cells
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Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein.
Manar I Nagy,Khaled M. Darwish,Safaa M. Kishk,Mohamed A. Tantawy,Ali Nasr,Mona Qushawy,Shady Swidan,Samia M. Mostafa,Ismail Salama +8 more
TL;DR: In this paper, a new series of benzimidazole-and indole-based derivatives as inhibitors of Bcl-2 protein was designed and synthesized for cancer treatment.
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DR-5 and DLL-4 mAb Functionalized SLNs of Gamma-Secretase Inhibitors- An Approach for TNBC Treatment
TL;DR: Solid lipid nanoparticles based drug delivery systems containing GSIs and surface modified with DR-5 and DLL4 monoclonal antibodies to effectivity target and treat TNBC are discussed.
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Nanotechnology in drug and gene delivery
TL;DR: In this article , the authors discuss various advanced nanomaterials designed to develop better nanocarrier systems used to face different diseases such as cancer, heart failure, and malaria.
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Satureja khuzistanica Essential Oil-Loaded Solid Lipid Nanoparticles Modified With Chitosan-Folate: Evaluation of Encapsulation Efficiency, Cytotoxic and Pro-apoptotic Properties
TL;DR: Molecular analysis showed that SEO-SCF-NPs could inhibit cancer cells by activating the internal pathway of apoptosis as well as cell cycle disruption in a suitable candidate for preclinical cancer studies.
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TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
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Selective degradation of mitochondria by mitophagy.
TL;DR: The term mitophagy is used to refer to mitochondrial degradation by autophagy, and the possible role of the mitochondrial permeability transition in mitophagic delivery to lysosomes is the major degradative pathway in mitochondrial turnover.
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p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
TL;DR: It is confirmed that p53 can mediate arrest at this stage, as well as in G1, and that irreversible arrest must involve processes other than or in addition to the interaction of p53-induced p21/WAF1 with G1 and G2 cyclin-dependent kinases.
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The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery.
Claudia Corbo,Roberto Molinaro,Alessandro Parodi,Naama E. Toledano Furman,Francesco Salvatore,Ennio Tasciotti +5 more
TL;DR: A survey of recent findings on the NP-PC interactions is provided and how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers is discussed.
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Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance
TL;DR: Novel approaches to selectively target cancer cells and overcome drug resistance phenomena, through the use of various nanometric drug delivery systems are highlighted.