The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery.
Claudia Corbo,Roberto Molinaro,Alessandro Parodi,Naama E. Toledano Furman,Francesco Salvatore,Ennio Tasciotti +5 more
TLDR
A survey of recent findings on the NP-PC interactions is provided and how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers is discussed.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2016-01-01 and is currently open access. It has received 463 citations till now. The article focuses on the topics: Nanocarriers & Protein Corona.read more
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Interview ラン・ラン
TL;DR: The State of Food Insecurity in the World 2012 (SOFI) and 2 billion have some form of micronutrient malnutrition as discussed by the authors, which constitutes a crime against humanity and is a responsibility for all of us.
Journal ArticleDOI
Protein corona: a new approach for nanomedicine design.
Van Hong Nguyen,Beom-Jin Lee +1 more
TL;DR: This review focuses on the formation of protein corona and its potential applications in pharmaceutical sciences such as prediction modeling based on NP-adsorbed proteins, usage of active proteins for modifying NP to achieve toxicity reduction, circulation time enhancement, and targeting effect.
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Surface Modifications of Nanoparticles for Stability in Biological Fluids.
TL;DR: The most common strategies to achieve stable NPs dispersions in high ionic strength fluids and, also, antifouling strategies to avoid the protein adsorption are reviewed.
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Biological Identity of Nanoparticles In Vivo: Clinical Implications of the Protein Corona
TL;DR: Recent advances in the understanding of the in vivo PC are reviewed and recent developments of quantitative models to predict biological interactions and how they offer new opportunities for the clinical translation of NPs are discussed.
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Size-Dependent Protein-Nanoparticle Interactions in Citrate-Stabilized Gold Nanoparticles: The Emergence of the Protein Corona.
TL;DR: Surface modifications of highly monodisperse citrate-stabilized gold nanoparticles studied and characterized by the combined use of UV-vis spectroscopy, dynamic light scattering, and zeta potential measurements, revealing the significant role that size plays in the kinetics of this process.
References
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Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles.
Tommy Cedervall,Iseult Lynch,Stina Lindman,Tord Berggård,Eva Thulin,Hanna Nilsson,Kenneth A. Dawson,Sara Linse +7 more
TL;DR: The rates of protein association and dissociation are determined using surface plasmon resonance technology with nanoparticles that are thiol-linked to gold, and through size exclusion chromatography of protein–nanoparticle mixtures, and this method is developed into a systematic methodology to isolate nanoparticle-associated proteins.