Current status of screening for colorectal cancer
Kjetil Garborg,Øyvind Holme,Magnus Løberg,Magnus Løberg,Mette Kalager,Mette Kalager,Hans-Olov Adami,Hans-Olov Adami,Michael Bretthauer,Michael Bretthauer +9 more
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TLDR
Current evidence for the most important tests that are widely used or under development for population-based screening for colorectal cancer screening is reviewed.About:
This article is published in Annals of Oncology.The article was published on 2013-08-01 and is currently open access. It has received 120 citations till now. The article focuses on the topics: Cancer screening & Population.read more
Citations
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Immunotherapy in colorectal cancer: rationale, challenges and potential.
Karuna Ganesh,Zsofia K. Stadler,Andrea Cercek,Robin B. Mendelsohn,Jinru Shia,Neil H. Segal,Luis A. Diaz +6 more
TL;DR: Clinical development of immune checkpoint inhibition in CRC leading to regulatory approvals for the treatment of dMMR–MSI-H CRC is reviewed and new advances in expanding the efficacy of immunotherapy to early-stage CRC and CRC that is mismatch-repair-proficient and has low microsatellite instability (pMMR- MSI-L) are focused on.
Journal ArticleDOI
Long-Term Colorectal-Cancer Mortality after Adenoma Removal
Magnus Løberg,Mette Kalager,Øyvind Holme,Geir Hoff,Hans-Olov Adami,Hans-Olov Adami,Hans-Olov Adami,Michael Bretthauer +7 more
TL;DR: After a median of 7.7 years of follow-up, colorectal-cancer mortality was lower among patients who had had low- risk adenomas removed and moderately higher among those who hadHad high-risk adenoma removed, as compared with the general population.
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Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update.
TL;DR: Incidence of mortality, its correlation with GH, and IGF-I levels and the shift in the main cause of mortality in patients with acromegaly are addressed and the effects of different acromEGaly treatment options on these complications are detailed.
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Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer
TL;DR: It is concluded that combined serum markers can be used to not only diagnose colorectal cancer, but also appraise the tumor status for guiding treatment, evaluation of curative effect, and prognosis of patients.
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American Geriatrics Society identifies five things that healthcare providers and patients should question.
TL;DR: Since 2012, the American Geriatrics Society (AGS) has also been collaborating with the ABIM Foundation, joining its "Choosing Wisely" campaign on two separate lists of Five Things Healthcare Providers and Patients Should Question.
References
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.
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Genetic alterations during colorectal-tumor development.
Bert Vogelstein,Eric R. Fearon,Stanley R. Hamilton,Scott E. Kern,Ann C. Preisinger,Mark Leppert,A M Smits,Johannes L. Bos +7 more
TL;DR: It is found that ras-gene mutations occurred in 58 percent of adenomas larger than 1 cm and in 47 percent of carcinomas, which are consistent with a model of colorectal tumorigenesis in which the steps required for the development of cancer often involve the mutational activation of an oncogene coupled with the loss of several genes that normally suppress tumors.
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Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup.
Sidney J. Winawer,A G Zauber,M N Ho,Michael J. O'Brien,Leonard S. Gottlieb,S S Sternberg,Jerome D. Waye,Melvin Schapiro,John H. Bond,Joel F. Panish +9 more
TL;DR: The results of the National Polyp Study support the view that colorectal adenomas progress to adenocarcinomas, as well as the current practice of searching for and removing adenomatous polyps to prevent coloreCTal cancer.
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Reducing Mortality from Colorectal Cancer by Screening for Fecal Occult Blood
Jack S. Mandel,John H. Bond,Timothy R. Church,Dale C. Snover,Bradley Gm,Leonard M. Schuman,Fred Ederer +6 more
TL;DR: Cutting mortality in the annually screened group was accompanied by improved survival in those with colorectal cancer and a shift to detection at an earlier stage of cancer.
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Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.
Bernard Levin,David A. Lieberman,Beth McFarland,Kimberly S. Andrews,Durado Brooks,John H. Bond,Chiranjeev Dash,Francis M. Giardiello,Seth N. Glick,David W. Johnson,C. Daniel Johnson,Theodore R. Levin,Perry J. Pickhardt,Douglas K. Rex,Robert A. Smith,Alan G. Thorson,Sidney J. Winawer +16 more
TL;DR: Clinicians should be prepared to offer patients a choice between a screening test that is effective at both early cancer detection and cancer prevention through the detection and removal of polyps and those that can detect cancer early and also can detect adenomatous polyps.