Journal ArticleDOI
Cytokine and cytokine receptor gene polymorphisms and their functionality
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TLDR
This review concentrates on the functionality of cytokine and cytokine receptor gene polymorphisms; it is through these variants that genuine disease-associations are based.About:
This article is published in Cytokine & Growth Factor Reviews.The article was published on 2009-02-01. It has received 326 citations till now. The article focuses on the topics: Cytokine Receptor Gene & Suppressor of cytokine signaling 1.read more
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Luigi Ferrucci,Elisa Fabbri +1 more
TL;DR: Whether therapies to modulate inflammageing can reduce the age-related decline in health is discussed, and the hypothesis that inflammation affects CVD, multimorbidity, and frailty is supported by mechanistic studies but requires confirmation in humans.
Journal ArticleDOI
Biology of interleukin-10
Robert Sabat,Gerald Grütz,Katarzyna Warszawska,Stefan Kirsch,Ellen Witte,Kerstin Wolk,Jens Geginat +6 more
TL;DR: The special physiological relevance of this cytokine lies in the prevention and limitation of over-whelming specific and unspecific immune reactions and, in consequence, of tissue damage.
Journal ArticleDOI
The Blood-Testis Barrier and Its Implications for Male Contraception
C. Yan Cheng,Dolores D. Mruk +1 more
TL;DR: Multiple potential targets are present at the BTB for innovative contraceptive development and for better delivery of drugs to alleviate toxicant-induced reproductive dysfunction in men, as well as critically evaluate findings in the field regarding studies on drug transporters in the testis.
Journal ArticleDOI
Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update.
Hua Su,Chun-Tao Lei,Chun Zhang +2 more
TL;DR: An overview of basic concept of IL- 6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells are provided.
Journal ArticleDOI
IL-10 family of cytokines
TL;DR: This review provides an overview of the most important and common aspects of the IL-10 family members.
References
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Journal ArticleDOI
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
Emad M. El-Omar,Emad M. El-Omar,Mary Carrington,Wong Ho Chow,Kenneth E.L. McColl,Jay H. Bream,Howard A. Young,Jesus Herrera,Jolanta Lissowska,Chiu Chin Yuan,Nathaniel Rothman,George Lanyon,Maureen P. Martin,Joseph F. Fraumeni,Charles S. Rabkin +14 more
TL;DR: It is reported that interleukin-1 gene cluster polymorphisms suspected of enhancing production of interleucine-1-beta are associated with an increased risk of both hypochlorhydria induced by H. pylori and gastric cancer.
Journal ArticleDOI
Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation
TL;DR: It is demonstrated, with reporter genes under the control of the two allelic TNF promoters, that TNF2 is a much stronger transcriptional activator than the common allele (TNF1) in a human B cell line.
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The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.
TL;DR: There is a genetically determined difference in the degree of the IL-6 response to stressful stimuli between individuals, and the reduced frequency of the potentially protective CC genotype in young S-JCA patients may contribute to its pathogenesis.
Journal ArticleDOI
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Eleftheria Zeggini,Laura J. Scott,Richa Saxena,Benjamin F. Voight,Jonathan Marchini,T Hu,de Bakker Piw.,de Bakker Piw.,de Bakker Piw.,Gonçalo R. Abecasis,Peter Almgren,Gregers S. Andersen,Kristin Ardlie,Kristina Bengtsson Boström,Richard N. Bergman,Lori L. Bonnycastle,Knut Borch-Johnsen,Knut Borch-Johnsen,Noël P. Burtt,H Chen,Peter S. Chines,Mark J. Daly,P Deodhar,Ding C-J.,Doney Asf.,William L. Duren,Katherine S. Elliott,Mike Erdos,Timothy M. Frayling,Rachel M. Freathy,Lauren Gianniny,Harald Grallert,Niels Grarup,Christopher J. Groves,Candace Guiducci,Torben Hansen,Christian Herder,Graham A. Hitman,Thomas Edward Hughes,Bo Isomaa,Anne U. Jackson,Torben Jørgensen,Augustine Kong,Kari Kubalanza,Finny G Kuruvilla,Finny G Kuruvilla,Johanna Kuusisto,Claudia Langenberg,Hana Lango,Torsten Lauritzen,Yun Li,Cecilia M. Lindgren,Cecilia M. Lindgren,Valeriya Lyssenko,Amanda F. Marvelle,Christine Meisinger,Kristian Midthjell,Karen L. Mohlke,Mario A. Morken,Andrew D. Morris,Narisu Narisu,Peter M. Nilsson,Katharine R. Owen,Palmer Cna.,Felicity Payne,Perry Jrb.,E Pettersen,Carl Platou,Inga Prokopenko,Inga Prokopenko,Lu Qi,Lu Qi,L Qin,Nigel W. Rayner,Nigel W. Rayner,Matthew G. Rees,J J Roix,A Sandbaek,Beverley M. Shields,Marketa Sjögren,Valgerdur Steinthorsdottir,Heather M. Stringham,Amy J. Swift,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Nicholas J. Timpson,Nicholas J. Timpson,Tiinamaija Tuomi,Jaakko Tuomilehto,Mark Walker,Richard M. Watanabe,Michael N. Weedon,Cristen J. Willer,Thomas Illig,Kristian Hveem,Frank B. Hu,Frank B. Hu,Markku Laakso,Kari Stefansson,Oluf Pedersen,Oluf Pedersen,Nicholas J. Wareham,Inês Barroso,Andrew T. Hattersley,Francis S. Collins,Leif Groop,Leif Groop,Mark I. McCarthy,Mark I. McCarthy,Michael Boehnke,David Altshuler +110 more
TL;DR: The results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D, and detect at least six previously unknown loci with robust evidence for association.
Journal ArticleDOI
An investigation of polymorphism in the interleukin-10 gene promoter.
TL;DR: Three single base pair substitutions in the IL-10 gene promoter are identified and it is investigated whether this polymorphism correlates withIL-10 protein production in vitro.