F
Finny G Kuruvilla
Researcher at Broad Institute
Publications - 7
Citations - 9648
Finny G Kuruvilla is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 7, co-authored 7 publications receiving 9055 citations. Previous affiliations of Finny G Kuruvilla include Massachusetts Institute of Technology & Harvard University.
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Journal ArticleDOI
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Shaun Purcell,Shaun Purcell,Naomi R. Wray,Jennifer Stone,Jennifer Stone,Peter M. Visscher,Michael Conlon O'Donovan,Patrick F. Sullivan,Pamela Sklar,Pamela Sklar,Douglas M. Ruderfer,Andrew McQuillin,Derek W. Morris,Colm O'Dushlaine,Aiden Corvin,Peter Holmans,Stuart MacGregor,Hugh Gurling,Douglas Blackwood,Nicholas John Craddock,Michael Gill,Christina M. Hultman,Christina M. Hultman,George Kirov,Paul Lichtenstein,Walter J. Muir,Michael John Owen,Carlos N. Pato,Edward M. Scolnick,Edward M. Scolnick,David St Clair,Nigel Williams,Lyudmila Georgieva,Ivan Nikolov,Nadine Norton,Hywel Williams,Draga Toncheva,Vihra Milanova,Emma Flordal Thelander,Patrick Sullivan,Elaine Kenny,Emma M. Quinn,Khalid Choudhury,Susmita Datta,Jonathan Pimm,Srinivasa Thirumalai,Vinay Puri,Robert Krasucki,Jacob Lawrence,Digby Quested,Nicholas Bass,Caroline Crombie,Gillian Fraser,Soh Leh Kuan,Nicholas Walker,Kevin A. McGhee,Ben S. Pickard,P. Malloy,Alan W Maclean,Margaret Van Beck,Michele T. Pato,Helena Medeiros,Frank A. Middleton,Célia Barreto Carvalho,Christopher P. Morley,Ayman H. Fanous,David V. Conti,James A. Knowles,Carlos Ferreira,António Macedo,M. Helena Azevedo,Andrew Kirby,Andrew Kirby,Manuel A. R. Ferreira,Manuel A. R. Ferreira,Mark J. Daly,Mark J. Daly,Kimberly Chambert,Finny G Kuruvilla,Stacey Gabriel,Kristin G. Ardlie,Jennifer L. Moran +81 more
TL;DR: The extent to which common genetic variation underlies the risk of schizophrenia is shown, using two analytic approaches, and the major histocompatibility complex is implicate, which is shown to involve thousands of common alleles of very small effect.
Journal ArticleDOI
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Eleftheria Zeggini,Laura J. Scott,Richa Saxena,Benjamin F. Voight,Jonathan Marchini,T Hu,de Bakker Piw.,de Bakker Piw.,de Bakker Piw.,Gonçalo R. Abecasis,Peter Almgren,Gregers S. Andersen,Kristin Ardlie,Kristina Bengtsson Boström,Richard N. Bergman,Lori L. Bonnycastle,Knut Borch-Johnsen,Knut Borch-Johnsen,Noël P. Burtt,H Chen,Peter S. Chines,Mark J. Daly,P Deodhar,Ding C-J.,Doney Asf.,William L. Duren,Katherine S. Elliott,Mike Erdos,Timothy M. Frayling,Rachel M. Freathy,Lauren Gianniny,Harald Grallert,Niels Grarup,Christopher J. Groves,Candace Guiducci,Torben Hansen,Christian Herder,Graham A. Hitman,Thomas Edward Hughes,Bo Isomaa,Anne U. Jackson,Torben Jørgensen,Augustine Kong,Kari Kubalanza,Finny G Kuruvilla,Finny G Kuruvilla,Johanna Kuusisto,Claudia Langenberg,Hana Lango,Torsten Lauritzen,Yun Li,Cecilia M. Lindgren,Cecilia M. Lindgren,Valeriya Lyssenko,Amanda F. Marvelle,Christine Meisinger,Kristian Midthjell,Karen L. Mohlke,Mario A. Morken,Andrew D. Morris,Narisu Narisu,Peter M. Nilsson,Katharine R. Owen,Palmer Cna.,Felicity Payne,Perry Jrb.,E Pettersen,Carl Platou,Inga Prokopenko,Inga Prokopenko,Lu Qi,Lu Qi,L Qin,Nigel W. Rayner,Nigel W. Rayner,Matthew G. Rees,J J Roix,A Sandbaek,Beverley M. Shields,Marketa Sjögren,Valgerdur Steinthorsdottir,Heather M. Stringham,Amy J. Swift,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Nicholas J. Timpson,Nicholas J. Timpson,Tiinamaija Tuomi,Jaakko Tuomilehto,Mark Walker,Richard M. Watanabe,Michael N. Weedon,Cristen J. Willer,Thomas Illig,Kristian Hveem,Frank B. Hu,Frank B. Hu,Markku Laakso,Kari Stefansson,Oluf Pedersen,Oluf Pedersen,Nicholas J. Wareham,Inês Barroso,Andrew T. Hattersley,Francis S. Collins,Leif Groop,Leif Groop,Mark I. McCarthy,Mark I. McCarthy,Michael Boehnke,David Altshuler +110 more
TL;DR: The results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D, and detect at least six previously unknown loci with robust evidence for association.
Journal ArticleDOI
Integrated detection and population-genetic analysis of SNPs and copy number variation
Steven A. McCarroll,Finny G Kuruvilla,Joshua M. Korn,Simon Cawley,James Nemesh,Alec Wysoker,Michael H. Shapero,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Julian Maller,Andrew Kirby,Amanda F. Elliott,Melissa Parkin,Earl Hubbell,Teresa Webster,Rui Mei,James Veitch,Patrick J Collins,Robert E. Handsaker,Steve Lincoln,Marcia M. Nizzari,John E. Blume,Keith W. Jones,Rich Rava,Mark J. Daly,Stacey Gabriel,David Altshuler +27 more
TL;DR: A map of human CNV (at 2-kb breakpoint resolution) informed by integer genotypes for 1,320 copy number polymorphisms (CNPs) that segregate at an allele frequency >1% is developed, indicating that large (>100 kb) CNVs affect much less of the genome than initially reported.
Journal ArticleDOI
Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs.
Joshua M. Korn,Finny G Kuruvilla,Steven A. McCarroll,Steven A. McCarroll,Alec Wysoker,James Nemesh,Simon Cawley,Earl Hubbell,Jim Veitch,Patrick J Collins,Katayoon Darvishi,Charles Lee,Marcia M. Nizzari,Stacey Gabriel,Shaun Purcell,Shaun Purcell,Mark J. Daly,Mark J. Daly,David Altshuler +18 more
TL;DR: Birdsuite is presented, a four-stage analytical framework instantiated in software for deriving integrated and mutually consistent copy number and SNP genotypes that more accurately depict the underlying sequence of each individual, reducing the rate of apparent mendelian inconsistencies.
Journal ArticleDOI
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Manuel A. Rivas,Manuel A. Rivas,Manuel A. Rivas,Mélissa Beaudoin,Agnes Gardet,Christine Stevens,Yashoda Sharma,Clarence K. Zhang,Gabrielle Boucher,Stephan Ripke,Stephan Ripke,David Ellinghaus,Noël P. Burtt,Timothy Fennell,Andrew Kirby,Andrew Kirby,Anna Latiano,Philippe Goyette,Todd Green,Jonas Halfvarson,Talin Haritunians,Joshua M. Korn,Finny G Kuruvilla,Caroline Lagacé,Benjamin M. Neale,Benjamin M. Neale,Ken Sin Lo,Phil Schumm,Leif Törkvist,Marla Dubinsky,Steven R. Brant,Mark S. Silverberg,Richard H. Duerr,David Altshuler,David Altshuler,Stacey Gabriel,Guillaume Lettre,Andre Franke,Mauro D'Amato,Dermot P.B. McGovern,Judy H. Cho,John D. Rioux,Ramnik J. Xavier,Ramnik J. Xavier,Mark J. Daly,Mark J. Daly +45 more
TL;DR: Next-generation sequencing is used to study 56 genes from regions associated with Crohn's disease in 350 cases and 350 controls to identify new, rare and probably functional variants that could aid functional experiments and predictive models.