Cytokine levels in patients with chikungunya virus infection.
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TLDR
This study provides additional information that these cytokines could play roles in pathogenesis of CHIKV infection and could be used as disease biomarkers or drug targets in patients with chikungunya virus (CHIKV) infection.About:
This article is published in Asian Pacific Journal of Tropical Medicine.The article was published on 2013-08-01 and is currently open access. It has received 54 citations till now. The article focuses on the topics: Chikungunya & Macrophage inflammatory protein.read more
Citations
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Journal ArticleDOI
The Role of Interleukin 6 During Viral Infections.
Journal ArticleDOI
Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen
Felicity J. Burt,Weiqiang Chen,Jonathan J. Miner,Deborah J. Lenschow,Andres Merits,Esther Schnettler,Alain Kohl,Penny A. Rudd,Adam Taylor,Lara J. Herrero,Ali Zaid,Lisa F. P. Ng,Lisa F. P. Ng,Suresh Mahalingam +13 more
TL;DR: An update on chikungunya virus with regard to its epidemiology, molecular virology, virus-host interactions, immunological responses, animal models, and potential antiviral therapies and vaccines is provided.
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A Novel Poxvirus-based Vaccine (MVA-CHIKV) is Highly Immunogenic and Protects Mice against Chikungunya Infection
Juan García-Arriaza,Victoria Cepeda,David Hallengärd,Carlos Oscar S. Sorzano,Beate M. Kümmerer,Peter Liljeström,Mariano Esteban +6 more
TL;DR: MVA-CHIKV is an effective vaccine against chikungunya virus infection that induced strong, broad, highly polyfunctional, and long-lasting CHIKV-specific CD8+ T cell responses, together with neutralizing antibodies against CHikV.
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Chikungunya, a paradigm of neglected tropical disease that emerged to be a new health global risk.
TL;DR: This review highlights the most recent advances in the knowledge and understanding of the epidemiology, biology, treatment and vaccination strategies of CHIKV.
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A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus Infection
Terk-Shin Teng,Yiu-Wing Kam,Bernett Lee,Hapuarachchige Chanditha Hapuarachchi,Abeyewickreme Wimal,Lee Ching Ng,Lisa F. P. Ng +6 more
TL;DR: This is the first study that associated levels of CHIKV load with arthralgia as an indicator of acute chikungunya virus infection and revealed specific immune mediator signatures that can be used to better define CHikV infection.
References
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An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features.
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Persistent Arthralgia Induced by Chikungunya Virus Infection is Associated with Interleukin-6 and Granulocyte Macrophage Colony-Stimulating Factor
Angela Chow,Zhisheng Her,Zhisheng Her,Edward K S Ong,Jinmiao Chen,Frederico Dimatatac,Dyan J. C. Kwek,Timothy Barkham,Henry Yang,Laurent Rénia,Yee Sin Leo,Lisa F. P. Ng,Lisa F. P. Ng +12 more
TL;DR: The level of CHIKV viremia during the acute phase determined specific patterns of pro-inflammatory cytokines, which were associated with disease severity, and at the chronic phase, levels of IL-6, and granulocyte macrophage colony-stimulating factor found to be associated with persistent arthralgia provide a possible explanation for the etiology of arthRALgia.
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Dengue and chikungunya virus infection in man in Thailand, 1962-1964. IV. Epidemiologic studies in the Bangkok metropolitan area.
TL;DR: Observations suggest a low level of anthropophilia in these species in Thailand and the possibility of a biological barrier to transmission of arboviruses by them to man.
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IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya Severity
Lisa F. P. Ng,Angela Chow,Yong-Jiang Sun,Dyan J. C. Kwek,Poh Lian Lim,Frederico Dimatatac,Lee Ching Ng,Eng Eong Ooi,Khar-Heng Choo,Zhisheng Her,Philippe Kourilsky,Yee Sin Leo +11 more
TL;DR: This is the first comprehensive report on the production of cytokines, chemokines, and growth factors during acute Chikungunya virus infection, and it is shown that an increase in IL-1β, IL-6 and a decrease in RANTES were associated with disease severity.
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The Acute Phase of Chikungunya Virus Infection in Humans Is Associated With Strong Innate Immunity and T CD8 Cell Activation
Nadia Wauquier,Pierre Becquart,Dieudonné Nkoghe,Cindy Padilla,Angélique Ndjoyi-Mbiguino,Eric M. Leroy +5 more
TL;DR: It is suggested that strong innate immunity is required to control Chikungunya virus infection.
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Jean-Jacques Hoarau,Marie-Christine Jaffar Bandjee,Pascale Krejbich Trotot,Trina Das,Ghislaine Li-Pat-Yuen,Bérengère Dassa,Melanie Denizot,Elsa Guichard,Anne Ribera,Tawfiq Henni,Frank Tallet,Marie Pierre Moiton,Bernard Alex Gaüzère,Sandrine Bruniquet,Zaïnoul Jaffar Bandjee,Philippe Morbidelli,Gérard Martigny,Michel Jolivet,Marc Grandadam,Hugues Tolou,Vincent Vieillard,Patrice Debré,Brigitte Autran,Philippe Gasque +23 more