Journal ArticleDOI
Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial
Georgina V. Long,Georgina V. Long,Daniil Stroyakovskiy,Helen Gogas,Evgeny Levchenko,Filippo de Braud,James Larkin,Claus Garbe,Thomas Jouary,Axel Hauschild,Jean-Jacques Grob,Vanna Chiarion-Sileni,Céleste Lebbé,Mario Mandalà,Michael Millward,Ana Arance,Igor Bondarenko,John B. A. G. Haanen,Johan Hansson,Jochen Utikal,Jochen Utikal,Virginia Ferraresi,Nadezhda Kovalenko,Peter Mohr,Volodymr Probachai,Dirk Schadendorf,Paul Nathan,Caroline Robert,Caroline Robert,Antoni Ribas,Douglas J Demarini,Jhangir G. Irani,Suzanne Swann,Jeffrey J. Legos,Fan Jin,Bijoyesh Mookerjee,Keith T. Flaherty +36 more
TLDR
The improvement in overall survival establishes the combination of dabrafenib and trametinib as the standard targeted treatment for BRAF Val600 mutation-positive melanoma.About:
This article is published in The Lancet.The article was published on 2015-08-01. It has received 1099 citations till now. The article focuses on the topics: Dabrafenib & Trametinib.read more
Citations
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Journal ArticleDOI
Decreased survival in patients treated by chemotherapy after targeted therapy compared to immunotherapy in metastatic melanoma.
Marie-Alix Mangin,Amélie Boespflug,Delphine Maucort Boulch,Charles-Hervé Vacheron,Isabelle Carpentier,Luc Thomas,Stéphane Dalle +6 more
TL;DR: In this paper, the authors evaluated if a previous treatment by ICI or MAPKi influences clinical outcomes in patients treated by CC in metastatic melanoma, and found that patients treated with CC after ICI tended to have a better median progression-free survival (PFS) compared with those previously treated by MAPKI.
Journal ArticleDOI
Monitoring of plasma concentrations of dabrafenib and trametinib in advanced BRAFV600mut melanoma patients.
M. Raynal,Jean-Claude Alvarez,Philippe Saiag,A. Beauchet,Christian Funck-Brentano,Elisa Funck-Brentano +5 more
TL;DR: In this paper, the authors investigated the relationship between Dabrafenib (D) and trametinib (T) in patients with BRAFV600mut melanoma.
Journal ArticleDOI
Monitoring of plasma concentrations of dabrafenib and trametinib in advanced BRAFV600 melanoma patients
TL;DR: In this article , high plasma concentration of D (PCD) is weakly associated with adverse events (AE), but no significant relationship was found between PCD and most common AEs (fever, lymphopenia, CPK increase, and hepatic cytolysis), body mass index, or age.
Journal ArticleDOI
Tolerance and Effectiveness of Targeted Therapies in Aged Patients with Metastatic Melanoma.
O. Becquart,Bastien Oriano,Stéphane Dalle,Laurent Mortier,Marie Thérèse Leccia,Caroline Dutriaux,Sophie Dalac,Henri Montaudié,Julie De Quatrebarbes,Florence Brunet-Possenti,Philippe Saiag,Thierry Lesimple,Marie Beylot-Barry,François Aubin,Pierre-Emmanuel Stoebner,Jean Philippe Arnault,Brigitte Dreno,Raphaël Porcher,Céleste Lebbé,Bernard Guillot +19 more
TL;DR: This study is the first to assess that TT is well tolerated in elderly BRAF-mutated patients such as in patients younger than 65, and shows that tolerance of targeted therapy is as good in older patients as in younger with a similar efficacy.
Journal ArticleDOI
Outcomes for systemic therapy in older patients with metastatic melanoma: Results from the Dutch Melanoma Treatment Registry.
A Jochems,Esther Bastiaannet,Maureen J.B. Aarts,Alexander C.J. van Akkooi,Franchette W P J van den Berkmortel,Marye J Boers-Sonderen,Alfonsus J. M. van den Eertwegh,Nienke G de Glas,Jan Willem B. de Groot,John B. A. G. Haanen,Geke A. P. Hospers,Jacobus J M van der Hoeven,Djura Piersma,Rozemarijn S. van Rijn,Karijn P M Suijkerbuijk,Albert J. ten Tije,Astrid A M van der Veldt,Gerard Vreugdenhil,Michiel C T van Zeijl,Ellen Kapiteijn,Michel W.J.M. Wouters +20 more
TL;DR: In this article, the authors analyzed a real-world cohort of 3054 patients with metastatic melanoma stratified for age (≤65 years, 66-74 years and ≥ 75 years), and BRAF status, providing data on treatment strategies, toxicity, and survival.
References
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New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
Elizabeth Eisenhauer,P. Therasse,Jan Bogaerts,Lawrence H. Schwartz,Daniel J. Sargent,Robert Ford,Janet Dancey,S. Arbuck,S. Gwyther,Margaret M. Mooney,Larry Rubinstein,Lalitha K. Shankar,Lori E. Dodd,Robert M. Kaplan,Denis Lacombe,Jaap Verweij +15 more
TL;DR: The revised RECIST includes a new imaging appendix with updated recommendations on the optimal anatomical assessment of lesions, and a section on detection of new lesions, including the interpretation of FDG-PET scan assessment is included.
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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
F. Stephen Hodi,Steven J. O'Day,David F. McDermott,R. W. Weber,Jeffrey A. Sosman,John B. A. G. Haanen,Rene Gonzalez,Caroline Robert,Dirk Schadendorf,Jessica C. Hassel,Wallace Akerley,Alfons J.M. van den Eertwegh,Jose Lutzky,Paul Lorigan,Julia Vaubel,Gerald P. Linette,David W. Hogg,Christian H. Ottensmeier,Céleste Lebbé,Christian Peschel,Ian Quirt,Joseph I. Clark,Jedd D. Wolchok,Jeffrey S. Weber,Jason Tian,Michael Yellin,Geoffrey M. Nichol,Axel Hoos,Walter J. Urba +28 more
TL;DR: Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma.
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Pembrolizumab versus Ipilimumab in Advanced Melanoma
Caroline Robert,Caroline Robert,Caroline Robert,Jacob Schachter,Georgina V. Long,Ana Arance,Jean-Jacques Grob,Laurent Mortier,Laurent Mortier,Adil Daud,Matteo S. Carlino,Catriona M. McNeil,Michal Lotem,James Larkin,Paul Lorigan,Bart Neyns,Christian U. Blank,Omid Hamid,Christine Mateus,Christine Mateus,Ronnie Shapira-Frommer,Ronnie Shapira-Frommer,Michele Kosh,Honghong Zhou,Nageatte Ibrahim,Scot Ebbinghaus,Antoni Ribas +26 more
TL;DR: The anti-PD-1 antibody pembrolizumab prolonged progression-free survival and overall survival and had less high-grade toxicity than did ipilimumab in patients with advanced melanoma.
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Nivolumab in previously untreated melanoma without BRAF mutation.
Caroline Robert,Georgina V. Long,Benjamin Brady,Caroline Dutriaux,Michele Maio,Laurent Mortier,Jessica C. Hassel,Piotr Rutkowski,Catriona M. McNeil,Ewa Kalinka-Warzocha,Kerry J. Savage,Micaela Hernberg,Céleste Lebbé,Julie Charles,Catalin Mihalcioiu,Vanna Chiarion-Sileni,Cornelia Mauch,Francesco Cognetti,Ana Arance,Henrik Schmidt,Dirk Schadendorf,Helen Gogas,Lotta Lundgren-Eriksson,Christine Horak,Brian Sharkey,Ian M. Waxman,Victoria Atkinson,Paolo A. Ascierto,Abstr Act +28 more
TL;DR: Nivolumab was associated with significant improvements in overall survival and progression-free survival, as compared with dacarbazine, among previously untreated patients who had metastatic melanoma without a BRAF mutation.
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A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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