Journal ArticleDOI
Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production.
Reads0
Chats0
TLDR
Daidzein has a direct stimulatory effect on bone formation in cultured osteoblastic cells in vitro, which may be mediated by increased production of BMPs in osteoblasts.About:
This article is published in Biochemical Pharmacology.The article was published on 2003-03-01. It has received 132 citations till now. The article focuses on the topics: Osteoblast & Daidzein.read more
Citations
More filters
Journal ArticleDOI
Functional and Edible Uses of Soy Protein Products
TL;DR: This article summarizes the integrated overview of the widely available, scattered information about the nutritional and functional uses of the soy proteins when applied in food systems and intends to present the most current knowledge with an interest to stimulate further research to optimize their beneficial effects.
Journal ArticleDOI
Evaluation for safety of antioxidant chemopreventive agents.
TL;DR: The results revealed that phytic acid, luteolin, and retinoic acid did not cause DNA damage under the experimental condition, and further studies on safety should be required when antioxidants are used for cancer prevention.
Journal ArticleDOI
Influence of extremely low frequency magnetic fields on Ca2+ signaling and NMDA receptor functions in rat hippocampus.
Pavan K. Manikonda,P. Rajendra,D. Devendranath,B. Gunasekaran,Channakeshava,R. S. S. Aradhya,Sashidhar Rb,C. Subramanyam +7 more
TL;DR: The combined results suggest that perturbed neuronal functions caused by ELF exposure may involve altered Ca(2+) signaling events contributing to aberrant NMDA receptor activities.
Journal ArticleDOI
Dose-dependent effects of phytoestrogens on bone.
TL;DR: A new understanding of the mechanism of action of phytoestrogens is provided and could be important for future studies to find precise beneficial doses in vivo and in clinical trials.
Journal ArticleDOI
The Balance Between Concurrent Activation of ERs and PPARs Determines Daidzein‐Induced Osteogenesis and Adipogenesis
TL;DR: Transcriptional and biochemical data show that PPARs, in addition to ERs, are molecular targets of daidzein, which divergently regulates osteogenesis and adipogenesis.
References
More filters
Journal ArticleDOI
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
TL;DR: A regulatory loop, which involves the hormone leptin, may help to explain the protective effect of obesity on bone mass in humans and provide a novel physiologic concept that may shed light on the etiology of osteoporosis and help to identify new therapeutic targets.
Journal ArticleDOI
Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1.
TL;DR: In this article, the authors reviewed the regulation of osteoblast differentiation mediated by the local factors such as bone morphogenetic proteins (BMPs) and hedgehogs and the transcription factor, core-binding factor alpha-1 (Cbfa1).
Journal ArticleDOI
Osteoblast and chondroblast differentiation.
TL;DR: This work focuses on the osteoprogenitors that divide and differentiate into mature OBs forming bone nodules in fetal rat calvaria cell cultures, and uses cellular, immunocytochemical, and molecular approaches, including PCR on small numbers of cells, to discriminate stages.
Journal ArticleDOI
Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2.
TL;DR: It is demonstrated that stem cells within the stromal compartment of bone marrow are capable of rapidly acquiring osteoblast features and a potential role for glucocorticoids in combination with BMP-2 and vitamin D in stages of osteogenic development is suggested.
Journal ArticleDOI
Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis
Bahram H. Arjmandi,Lee Alekel,Bruce W. Hollis,Daxa Amin,Maria Stacewicz-Sapuntzakis,Peilin Guo,Subhash C. Kukreja +6 more
TL;DR: The findings suggest that dietary soybean protein is effective in preventing bone loss due to ovarian hormone deficiency, and confirms that ovariectomy enhances and 17 beta-estradiol suppresses the rate of bone turnover.
Related Papers (5)
Stimulatory effect of Daidzein in osteoblastic MC3T3-E1 cells.
Emi Sugimoto,Masayoshi Yamaguchi +1 more