De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017
Giuseppe Curigliano,Harold J. Burstein,Eric P. Winer,Michael Gnant,Peter Dubsky,Sibylle Loibl,Marco Colleoni,Meredith M. Regan,Martine Piccart-Gebhart,H.-J. Senn,Beat Thürlimann,Fabrice Andre,José Baselga,Jonas Bergh,Hervé Bonnefoi,Sara Y. Brucker,Fatima Cardoso,Lisa A. Carey,Eva Ciruelos,Jack Cuzick,Carsten Denkert,A. Di Leo,Bent Ejlertsen,Prudence A. Francis,Viviana Galimberti,Judy Garber,Bahadir M. Gulluoglu,Pamela J. Goodwin,Nadia Harbeck,Daniel F. Hayes,Chiun-Sheng Huang,Jens Huober,H. Khaled,Jacek Jassem,Zefei Jiang,Per Karlsson,Monica Morrow,Roberto Orecchia,Kent Osborne,Olivia Pagani,Ann H. Partridge,Kathleen I. Pritchard,Jungsil Ro,Emiel J. Th. Rutgers,Felix Sedlmayer,Vladimir Semiglazov,Zhimin Shao,I.E. Smith,Masakazu Toi,Andrew Tutt,Giuseppe Viale,Toshihiro Watanabe,Timothy J. Whelan,Bo Xu +53 more
TLDR
The 15th St. Gallen International Breast Cancer Conference 2017 in Vienna, Austria reviewed substantial new evidence on loco-regional and systemic therapies for early breast cancer, and recommended bisphosphonate use in postmenopausal women to prevent breast cancer recurrence.About:
This article is published in Annals of Oncology.The article was published on 2017-08-01 and is currently open access. It has received 777 citations till now. The article focuses on the topics: Breast cancer & Adjuvant therapy.read more
Citations
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Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Elżbieta Senkus,Stella Kyriakides,Frédérique Penault-Llorca,P.M. Poortmans,Alexander J. Thompson,Sophia Zackrisson,Fatima Cardoso +6 more
TL;DR: This work presents the results of a meta-analysis conducted at the 2016 European Oncology and Radiotherapy Guidelines Working Group (ESMO) workshop on breast cancer diagnosis and prognosis of women with atypical central giant cell granuloma (CGM) who have previously had surgery.
Journal ArticleDOI
Estimating the Benefits of Therapy for Early Stage Breast Cancer The St Gallen International Consensus Guidelines for the Primary Therapy of Early Breast Cancer 2019
Harold J. Burstein,Giuseppe Curigliano,S. Loibl,P Dubsky,M. Gnant,Philip Poortmans,Marco Colleoni,Carsten Denkert,Martine Piccart-Gebhart,Meredith M. Regan,Hans-Jörg Senn,Eric P. Winer,Beat Thürlimann +12 more
TL;DR: The 16th St. Gallen International Breast Cancer Conference 2019 as mentioned in this paper reviewed substantial new evidence on loco-regional and systemic therapies for early breast cancer, and encouraged clinicians and patients to routinely discuss the magnitude of benefit for interventions as part of the development of the treatment plan.
Journal ArticleDOI
Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy.
Wei Chang Colin Tan,Sanjna Nilesh Nerurkar,Hai Yun Cai,Harry Ho Man Ng,Harry Ho Man Ng,Duoduo Wu,Yu Ting Felicia Wee,Jeffrey Chun Tatt Lim,Joe Yeong,Joe Yeong,Joe Yeong,Tony Kiat Hon Lim +11 more
TL;DR: Various highly multiplexed techniques that have emerged to circumvent constraints, allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition, cellular functional and cell‐cell interactions are detailed.
Journal ArticleDOI
Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer
TL;DR: In this article , the authors reported that the addition of pembrolizumab to neoadjuvant chemotherapy led to a significantly higher percentage of patients with early triple-negative breast cancer having a pathological complete response (defined as no invasive cancer in the breast and negative nodes) at definitive surgery.
Journal ArticleDOI
Platinum-based neoadjuvant chemotherapy in triple-negative breast cancer: A systematic review and meta-analysis
Francesca Poggio,Francesca Poggio,Marco Bruzzone,Marcello Ceppi,Noam Pondé,G. La Valle,L. Del Mastro,E. de Azambuja,Matteo Lambertini +8 more
TL;DR: In TNBC patients, platinum-based neoadjuvant chemotherapy is associated with significantly increased pCR rates at the cost of worse hematological toxicities, with no increased risk of grade 3 and 4 neuropathy.
References
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Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: A randomized clinical trial
Armando E. Giuliano,Kelly K. Hunt,Karla V. Ballman,Peter D. Beitsch,Pat Whitworth,Peter W. Blumencranz,A. Marilyn Leitch,Sukamal Saha,Linda M. McCall,Monica Morrow +9 more
TL;DR: Among patients with limited SLN metastatic breast cancer treated with breast conservation and systemic therapy, the use of SLND alone compared with ALND did not result in inferior survival, and overall survival was the primary end point, with a noninferiority margin of a 1-sided hazard ratio of less than 1.3 indicating thatSLND alone is noninherited.
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Palbociclib and Letrozole in Advanced Breast Cancer
Richard S. Finn,Miguel Martin,Hope S. Rugo,Stephen R. Jones,Seock-Ah Im,Karen A. Gelmon,Nadia Harbeck,Oleg Lipatov,Janice M. Walshe,Stacy L. Moulder,Eric Gauthier,Dongrui R. Lu,Sophia Randolph,Véronique Diéras,Dennis J. Slamon +14 more
TL;DR: Among patients with previously untreated ER-positive, HER2-negative advanced breast cancer, palbociclib combined with letrozole resulted in significantly longer progression-free survival than that with let rozole alone, although the rates of myelotoxic effects were higher with palbokiclib-letrozoles.
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Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials.
Richard Peto,C Davies,Jon Godwin,Richard Gray,Hongchao Pan,Mike Clarke,D Cutter,Sarah C. Darby,Paul McGale,Carolyn W. Taylor,Yixin Wang,Jonas Bergh,A. Di Leo,KS Albain,Sandra M. Swain,M.J. Piccart,Kathleen I. Pritchard +16 more
TL;DR: In meta-analyses involving taxane-based or anthracycline-based regimens, proportional risk reductions were little affected by age, nodal status, tumour diameter or differentiation (moderate or poor; few were well differentiated), oestrogen receptor status, or tamoxifen use.
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Long-Term Results of Hypofractionated Radiation Therapy for Breast Cancer
Timothy J. Whelan,Jean-Philippe Pignol,Mark Levine,Jim A. Julian,R. MacKenzie,Sameer Parpia,W Shelley,Laval Grimard,J. Bowen,Himu Lukka,Francisco Perera,Anthony Fyles,Ken Schneider,Sunil P.P. Gulavita,Carolyn R. Freeman +14 more
TL;DR: Ten years after treatment, accelerated, hypofractionated whole-breast irradiation was not inferior to standard radiation treatment in women who had undergone breast-conserving surgery for invasive breast cancer with clear surgical margins and negative axillary nodes.
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70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer
Fatima Cardoso,Laura J. van't Veer,Jan Bogaerts,Leen Slaets,Giuseppe Viale,Suzette Delaloge,Jean-Yves Pierga,Etienne Brain,Sylvain Causeret,Mauro Delorenzi,Annuska M. Glas,Vassilis Golfinopoulos,Theodora Goulioti,Susan J. Knox,Erika Matos,Bart Meulemans,Peter A. Neijenhuis,Ulrike Nitz,Rodolfo Passalacqua,Peter M. Ravdin,Isabel T. Rubio,Mahasti Saghatchian,Tineke J. Smilde,Christos Sotiriou,Lisette Stork,Carolyn Straehle,Geraldine A. Thomas,Alastair M. Thompson,Jacobus J.M. van der Hoeven,Peter Vuylsteke,René Bernards,Konstantinos Tryfonidis,Emiel J. Th. Rutgers,Martine Piccart +33 more
TL;DR: Among women with early-stage breast cancer who were at high clinical risk and low genomic risk for recurrence, the receipt of no chemotherapy on the basis of the 70-gene signature led to a 5-year rate of survival without distant metastasis that was 1.5 percentage points lower than the rate with chemotherapy.
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