Demasculinization and feminization of male gonads by atrazine: Consistent effects across vertebrate classes
Tyrone B. Hayes,Lloyd L. Anderson,Val R. Beasley,Shane R. de Solla,Taisen Iguchi,Holly A. Ingraham,Patrick Kestemont,Jasna Kniewald,Zlatko Kniewald,Valerie S. Langlois,Enrique H. Luque,Krista A. McCoy,Mónica Muñoz-de-Toro,Tomohiro Oka,Cleida A. Oliveira,Frances Orton,Sylvia M. Ruby,Miyuki Suzawa,Luz E. Tavera-Mendoza,Vance L. Trudeau,Anna Bolivar Victor-Costa,Emily Willingham +21 more
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TLDR
The case for atrazine as an endocrine disruptor that demasculinizes and feminizes male vertebrates meets all nine of the "Hill criteria" for establishing cause-effect relationships.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2011-10-01 and is currently open access. It has received 311 citations till now. The article focuses on the topics: Atrazine & Feminization (biology).read more
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Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses
Laura N. Vandenberg,Theo Colborn,Tyrone B. Hayes,Jerrold J. Heindel,David R. Jacobs,Duk Hee Lee,Toshi Shioda,Ana M. Soto,Wade V. Welshons,R. Thomas Zoeller,John Peterson Myers +10 more
TL;DR: It is concluded that when nonmonotonic dose-response curves occur, the effects of low doses cannot be predicted by the effects observed at high doses, and fundamental changes in chemical testing and safety determination are needed to protect human health.
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Recent advances in nano-enabled fertilizers and pesticides: a critical review of mechanisms of action
Ishaq O. Adisa,Venkata L. Reddy Pullagurala,Jose R. Peralta-Videa,Christian O. Dimkpa,Wade H. Elmer,Jorge L. Gardea-Torresdey,Jason C. White +6 more
TL;DR: In this paper, the use of nanomaterials in agriculture as nanofertilizers, nanopesticides, or nano-enabled sensors to increase crop yield is gaining increasing interest.
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Investing in the transition to sustainable agriculture
TL;DR: In this paper, the amount of federal funding available for agroecology has remained unclear, and the authors identified projects beginning in 2014 from the USDA Current Research Information System (CRIS) database and searched key sections of project reports for major components emphasizing sustainable agriculture, including agro-ecology.
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State of the evidence 2017: an update on the connection between breast cancer and the environment
TL;DR: Evidence from epidemiological studies, as well as a better understanding of mechanisms linking toxicants with development of breast cancer, all reinforce the conclusion that exposures to these substances – many of which are found in common, everyday products and byproducts – may lead to increased risk of developing breast cancer.
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Environmental immune disruptors, inflammation and cancer risk.
Patricia A. Thompson,Mahin Khatami,Carolyn J. Baglole,Jun Sun,Shelley A. Harris,Eun-Yi Moon,Fahd Al-Mulla,Rabeah Al-Temaimi,Dustin G. Brown,Annamaria Colacci,Chiara Mondello,Jayadev Raju,Elizabeth P. Ryan,Jordan Woodrick,A. Ivana Scovassi,Neetu Singh,Monica Vaccari,Rabindra Roy,Stefano Forte,Lorenzo Memeo,Hosni Salem,Amedeo Amedei,Roslida Abd Hamid,Leroy Lowe,Tiziana Guarnieri,William H. Bisson +25 more
TL;DR: The role that the innate immune cells of inflammatory responses play in tumorigenesis is reviewed and the evidence linking environmental toxicant exposures with perturbation in the balance between pro- and anti-inflammatory responses is reviewed.
References
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The environment and disease: association or causation?
TL;DR: The criteria outlined in "The Environment and Disease: Association or Causation?" help identify the causes of many diseases, including cancers of the reproductive system.
Journal Article
The environment and disease: association or causation?
TL;DR: This paper contrasts Bradford Hill’s approach with a currently fashionable framework for reasoning about statistical associations – the Common Task Framework – and suggests why following Bradford Hill, 50+ years on, is still extraordinarily reasonable.
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Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses.
Tyrone B. Hayes,Atif Collins,Melissa Lee,Magdelena Mendoza,Nigel C. Noriega,A Ali Stuart,Aaron Vonk +6 more
TL;DR: It is hypothesize that atrazine induces aromatase and promotes the conversion of testosterone to estrogen and likely explains the demasculinization of the male larynx and the production of hermaphrodites.
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Ecological risk assessment of atrazine in North American surface waters.
Keith R. Solomon,David B. Baker,R. Peter Richards,Kenneth R. Dixon,Stephen J. Klaine,Thomas W. La Point,Ronald J. Kendall,Carol P. Weisskopf,Jeffrey M. Giddings,John P. Giesy,Lenwood W. Hall,W. Marty Williams +11 more
TL;DR: In this paper, an expert panel was convened to conduct a comprehensive aquatic ecological risk assessment based on several newly suggested procedures and included exposure and hazard subcomponents as well as the overall risk assessment.