Journal ArticleDOI
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TLDR
After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.Abstract:
Long-term enhancement of synaptic efficacy in the hippocampus is an important model for studying the cellular mechanisms of neuronal plasticity, circuit reorganization, and even learning and memory. Although these long-lasting functional changes are easy to induce, it has been very difficult to demonstrate that they are accompanied or even caused by morphological changes on the subcellular level. Here we combined a local superfusion technique with two-photon imaging, which allowed us to scrutinize specific regions of the postsynaptic dendrite where we knew that the synaptic changes had to occur. We show that after induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrite or in slices where long-term potentiation was blocked, no significant spine growth occurred.read more
Citations
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The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
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Long-Term Potentiation--A Decade of Progress?
TL;DR: A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.
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Structural basis of long-term potentiation in single dendritic spines
TL;DR: The results indicate that spines individually follow Hebb's postulate for learning and suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long- term memory.
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Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
Joshua T. Trachtenberg,Brian E. Chen,Graham Knott,Guoping Feng,Joshua R. Sanes,Egbert Welker,Karel Svoboda +6 more
TL;DR: The measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits.
References
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TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
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Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex
TL;DR: In this paper, the development of stimulus selectivity in the primary sensory cortex of higher vertebrates is considered in a general mathematical framework and a synaptic evolution scheme of a new kind is proposed in which incoming patterns rather than converging afferents compete.
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Related Papers (5)
Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
Structural basis of long-term potentiation in single dendritic spines
Morphological changes in dendritic spines associated with long-term synaptic plasticity.
Rafael Yuste,Tobias Bonhoeffer +1 more