Detailed comparative map of human chromosome 19q and related regions of the mouse genome
Lisa Stubbs,Ethan A. Carver,Mark Shannon,Joomyeong Kim,John Geisler,Estela E. Generoso,Beverly G. Stanford,William C. Dunn,Harvey W. Mohrenweiser,Wolfgang Zimmermann,Suzanne M. Watt,Linda K. Ashworth +11 more
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TLDR
The results demonstrate that despite an overall inversion of sequences relative to the centromere, apparent "transpositions" of three gene-rich segments, and a local inversions of markers mapping near the 19q telomere, gene content, order, and spacing are remarkably well conserved throughout the lengths of these related mouse and human regions.Citations
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A physical map of the mouse genome.
Simon G. Gregory,Mandeep Sekhon,Jacqueline E. Schein,Shaying Zhao,Kazutoyo Osoegawa,Carol Scott,R Evans,Paul W. Burridge,Tony Cox,Christopher A Fox,Richard D. Hutton,Ian R Mullenger,Kimbly J Phillips,James Smith,Jim Stalker,Glen Threadgold,Ewan Birney,Kristine M. Wylie,Asif T. Chinwalla,John W. Wallis,LaDeana W. Hillier,Jason Carter,Tony Gaige,Sara Jaeger,Colin Kremitzki,Dan Layman,Jason Maas,Rebecca McGrane,Kelly Mead,Rebecca S. Walker,Steven J.M. Jones,Michael Smith,Jennifer Asano,Ian Bosdet,Susanna Chan,Suganthi Chittaranjan,Readman Chiu,Chris Fjell,Dan Fuhrmann,Noreen Girn,Catharine Gray,Ran Guin,Letticia Hsiao,Martin Krzywinski,Reta Kutsche,Soo Sen Lee,Carrie Mathewson,Candice McLeavy,Steve Messervier,Steven R. Ness,Pawan Pandoh,Anna-Liisa Prabhu,Parvaneh Saeedi,Duane E Smailus,Lorraine Spence,Jeffrey L Stott,Sheryl Taylor,Wesley Terpstra,Miranda Tsai,Jill Vardy,Natasja Wye,George S. Yang,Sofiya Shatsman,Bola Ayodeji,Keita Geer,Getahun Tsegaye,Alla Shvartsbeyn,Elizabeth Gebregeorgis,Margaret Krol,Daniel A. Russell,Larry Overton,Joel A. Malek,Michael C. Holmes,Michael Heaney,Jyoti Shetty,Tamara Feldblyum,William C. Nierman,Joseph J. Catanese,Tim Hubbard,Robert H. Waterston,Jane Rogers,Pieter J. de Jong,Claire M. Fraser,Marco A. Marra,John Douglas Mcpherson,David R. Bentley +85 more
TL;DR: A physical map of the mouse genome that contains 296 contigs of overlapping bacterial clones and 16,992 unique markers is constructed, enabling identification of a mouse clone that corresponds to almost any position in the human genome.
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Comparison of the genomes of human and mouse lays the foundation of genome zoology
TL;DR: It is predicted that the availability of numerous animal genomes will give rise to a new field of genome zoology in which differences in animal physiology and ethology are illuminated by the study of genomic sequence variations.
Journal ArticleDOI
A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors
TL;DR: A new family of monocyte/macrophage immunoglobulin-like receptors (MIRs) related to KIR is identified, which should facilitate studies of the evolution and function of the MIR and KIR families.
Journal ArticleDOI
The zinc finger protein nrif interacts with the neurotrophin receptor p75ntr and participates in programmed cell death
Elisabeth Casademunt,Bruce D. Carter,Isabel Benzel,José María Frade,Georg Dechant,Yves-Alain Barde +5 more
TL;DR: Results indicate that NRIF is an intracellular p75NTR‐binding protein transducing cell death signals during development, and not just a ubiquitously expressed zinc finger protein of the Krüppel family.
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Zooming in on the Human–Mouse Comparative Map: Genome Conservation Re-examined on a High-Resolution Scale
Ethan A. Carver,Lisa Stubbs +1 more
TL;DR: Advances in high-resolution conserved marker-based maps are currently available only for human and mouse, and a variety of new methods and resources are speeding the development of comparative maps of additional organisms, marking the first step toward establishment of the human genome as a reference map for vertebrate species.