L
Linda K. Ashworth
Researcher at Lawrence Livermore National Laboratory
Publications - 48
Citations - 2573
Linda K. Ashworth is an academic researcher from Lawrence Livermore National Laboratory. The author has contributed to research in topics: Chromosome 19 & Gene. The author has an hindex of 25, co-authored 48 publications receiving 2504 citations. Previous affiliations of Linda K. Ashworth include Oak Ridge National Laboratory & Joint Genome Institute.
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Journal ArticleDOI
The DNA sequence and biology of human chromosome 19
Jane Grimwood,Laurie Gordon,Laurie Gordon,Anne S. Olsen,Anne S. Olsen,Astrid Terry,Jeremy Schmutz,Jane Lamerdin,Jane Lamerdin,Uffe Hellsten,David Goodstein,Olivier Couronne,Mary Bao Tran-Gyamfi,Mary Bao Tran-Gyamfi,Andrea Aerts,Michael R. Altherr,Michael R. Altherr,Linda K. Ashworth,Linda K. Ashworth,Eva Bajorek,Stacey Black,Elbert Branscomb,Elbert Branscomb,Sean Caenepeel,Anthony V. Carrano,Anthony V. Carrano,Chenier Caoile,Yee Man Chan,Mari Christensen,Mari Christensen,Catherine A. Cleland,Catherine A. Cleland,Alex Copeland,Eileen Dalin,Paramvir S. Dehal,Mirian Denys,John C. Detter,Julio Escobar,Dave Flowers,Dea Fotopulos,Carmen Rosa Albacete García,Anca M. Georgescu,Anca M. Georgescu,Tijana Glavina,Maria Gomez,Eidelyn Gonzales,Matthew Groza,Matthew Groza,Nancy Hammon,Trevor Hawkins,Lauren Haydu,Isaac Ho,Wayne Huang,Sanjay Israni,Jamie Jett,Kristen Kadner,Heather Kimball,Arthur Kobayashi,Arthur Kobayashi,Vladimer Larionov,Sun-Hee Leem,Frederick Lopez,Yunian Lou,Steve Lowry,Stephanie Malfatti,Stephanie Malfatti,Diego Martinez,Paula McCready,Paula McCready,Catherine Medina,Jenna Morgan,Kathryn Nelson,Kathryn Nelson,Matt Nolan,Ivan Ovcharenko,Ivan Ovcharenko,Sam Pitluck,Martin Pollard,Anthony P. Popkie,Paul Predki,Glenda Quan,Glenda Quan,Lucía Ramírez,Sam Rash,James Retterer,Alex Rodriguez,Stephanine Rogers,Asaf Salamov,Angelica Salazar,Xinwei She,Doug Smith,Tom Slezak,Tom Slezak,Victor V. Solovyev,Nina Thayer,Nina Thayer,Hope Tice,Ming Tsai,Anna Ustaszewska,Nu Vo,Mark C. Wagner,Mark C. Wagner,Jeremy Wheeler,Kevin Wu,Gary Xie,Gary Xie,Joan Yang,Inna Dubchak,Terrence S. Furey,Pieter J. deJong,Mark Dickson,David Gordon,Evan E. Eichler,Len A. Pennacchio,Paul G. Richardson,Lisa Stubbs,Lisa Stubbs,Daniel S. Rokhsar,Richard M. Myers,Edward M. Rubin,Susan Lucas +120 more
TL;DR: Comparative analyses show a fascinating picture of conservation and divergence, revealing large blocks of gene orthology with rodents, scattered regions with more recent gene family expansions and deletions, and segments of coding and non-coding conservation with the distant fish species Takifugu.
Journal ArticleDOI
New Nomenclature for the Human Tissue Kallikrein Gene Family
Eleftherios P. Diamandis,Eleftherios P. Diamandis,George M. Yousef,George M. Yousef,Judith A. Clements,Linda K. Ashworth,Shigetaka Yoshida,Torbjörn Egelrud,Peter S. Nelson,Sadao Shiosaka,Sheila P. Little,Hans Lilja,Ulf-Håkan Stenman,Harry G. Rittenhouse,H Wain +14 more
TL;DR: The human kallikrein gene family is important to the discipline of clinical chemistry because it contains genes that encode for valuable cancer biomarkers, including the best tumor marker available today, prostate-specific antigen (PSA).
Journal ArticleDOI
An integrated metric physical map of human chromosome 19.
Linda K. Ashworth,Mark A. Batzer,B. F. Brandriff,Elbert Branscomb,P. De Jong,P. De Jong,Emilio Garcia,Jeffrey Garnes,Laurie Gordon,Jane Lamerdin,Gregory G. Lennon,Harvey W. Mohrenweiser,Anne S. Olsen,Tom Slezak,Anthony V. Carrano +14 more
TL;DR: A metric physical map of human chromosome 19 has been generated and currently, the map consists of 51 ‘islands’ containing multiple clone types, whose size, order and relative distance are known.
Journal ArticleDOI
Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.
Tracey J. Harvey,John D. Hooper,Stephen Myers,Sally-Anne Stephenson,Linda K. Ashworth,Judith A. Clements +5 more
TL;DR: An extensive analysis of the expression patterns of these genes by poly(A)+ RNA dot blot and reverse transcriptase-polymerase chain reaction analysis, and demonstrated a diverse pattern of expression suggesting evolutionary conservation of elements conferring tissue specificity.
Journal ArticleDOI
A high-resolution, fluorescence-based, semiautomated method for DNA fingerprinting.
Anthony V. Carrano,Jane Lamerdin,Linda K. Ashworth,B. W. Watkins,Elbert Branscomb,Tom Slezak,Malcolm Raff,P.J. de Jong,Douglas H. Keith,Lincoln J. Mcbride,S. Meister,M N Kronick +11 more
TL;DR: A fluorescence-based method for the automated analysis of DNA fragments on polyacrylamide gels offers very near single-base resolution up to 400 bases and the ability to quantitate fragment size up to 2000 bases and is applied to the analysis of overlapping cosmids.