Open AccessJournal Article
Development of a Lipid Particle for β-Carotene Encapsulation Using a Blend of Tristearin and Sunflower Oil: Choice of Lipid Matrix and Evaluation of Shelf Life of Dispersions
Graziela V. L. Gomes,Izabella A. S. Simplicio,Eliana B. Souto,Lisandro Pavie Cardoso,Samantha Cristina de Pinho +4 more
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TLDR
In this article, the authors choose a suitable lipid matrix to produce solid lipid particles, which would be used to encapsulate b-carotene, and evaluate the capacity of dispersions to protect the incorporated carotenoid.Abstract:
Summary Solid lipid particles are colloidal carriers that have been studied for almost 20 years in the pharmaceutical field and recently have been investigated by food researchers due to their capacity to enhance the incorporation of lipophilic bioactives and their bioavailability in aqueous formulations. The aims of this study are to choose a suitable lipid matrix to produce solid lipid particles, which would be used to encapsulate b-carotene, and to evaluate the capacity of dispersions to protect the incorporated carotenoid. Bulk lipid mixtures of tristearin and sunflower oil were analysed by differential scanning calorimetry and wide angle X-ray diffraction, and the mixture with the highest degree of structural disorganisation was chosen. b-Carotene was then encapsulated in solid lipid particles produced with this mixture, composed of 70 % tristearin and 30 % sunflower oil (6 % total lipid) and stabilised with hydrogenated soy lecithin and Tween 80 (3 % total surfactant) by hot pressure homogenisation. Two types of particles were produced, using one or two passages in the homogenisation step. Average particle size, zeta potential, thermal behaviour, crystallinity and b-carotene concentration were monitored over 4 months of storage (under refrigerated conditions). The results showed minor differences between the systems in terms of size distribution, although the particles produced with one passage through the homogeniser were slightly more efficient at protecting the b-carotene from degradation and also suffered few microstructural alterations after 4 months.read more
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Advances in nanoparticle and microparticle delivery systems for increasing the dispersibility, stability, and bioactivity of phytochemicals.
TL;DR: This review evaluates recent advances in the development of phytochemical oral delivery systems, including microemulsions, nanoemulsion, emulsion, solid lipid nanoparticles, liposomes, and biopolymer microgels.
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Encapsulation of (─)-epigallocatechin-3-gallate (EGCG) in solid lipid nanoparticles for food applications
TL;DR: In this paper, a nanoparticlulate delivery system was prepared for developing a food grade carrier for the major bioactive constituent in green tea; (─)-epigallocatechingallate (EGCG), in order to protect it against degradation during storage and digestion under simulated gastrointestinal pH conditions.
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Effect of surfactant concentration and solidification temperature on the characteristics and stability of nanostructured lipid carrier (NLC) prepared from rambutan (Nephelium lappaceum L.) kernel fat.
TL;DR: These stable NLC particles produced from rambutan kernel fat may serve as useful carriers for the delivery of bioactive lipophilic nutraceuticals and pre-solidification at 5°C could createstable NLC with monodispersed-spherical lipid particles.
Journal ArticleDOI
Physico-chemical stability and in vitro digestibility of beta-carotene-loaded lipid nanoparticles of cupuacu butter (Theobroma grandiflorum) produced by the phase inversion temperature (PIT) method
Graziela V. L. Gomes,Mirella R. Sola,Luis F. P. Marostegan,Camila G. Jange,Camila Pinheiro Silva Cazado,Ana Cristina Pinheiro,António A. Vicente,Samantha Cristina de Pinho +7 more
TL;DR: In this article, a phase inversion temperature (PIT) method was used to produce lipid nanoparticles from 10% cupuacu butter and 20% surfactant (Cremophor RH40 and Span 80).
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β-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method.
Davi Rocha Bernardes Oliveira,Mariano Michelon,Guilherme de Figueiredo Furtado,Rita Sinigaglia-Coimbra,Rosiane Lopes da Cunha +4 more
TL;DR: Nanostructured lipid carriers exhibited advantages over the solid lipid nanoparticles, such as enhanced drug loading capacity and prevention of drug expulsion, which makes this a versatile delivery system for food applications.
References
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Stearyl ferulate-based solid lipid nanoparticles for the encapsulation and stabilization of β-carotene and α-tocopherol
TL;DR: Stearyl ferulate-based solid lipid nanoparticles (SF-SLNs), as vehicles for beta-carotene and alpha-tocopherol, were formulated to improve the stability of these compounds and highlighted how they represent a suitable vehicle for stabilizing and protecting them from degradation.
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Further characterization of theobroma oil–beeswax admixtures as lipid matrices for improved drug delivery systems
TL;DR: Modifications of mixtures of beeswax and theobroma oil could be applied in the formulation of solid lipid nanoparticles and nanostructured lipid carriers as these lipid matrices possessed crystal characteristics that favour such drug delivery systems.
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Optimization of β-carotene loaded solid lipid nanoparticles preparation using a high shear homogenization technique
TL;DR: Solid lipid nanoparticle technology can be sufficiently robust from a design standpoint to become commercially viable, using statistical experimental design methodologies.
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Release of lipophilic molecules during in vitro digestion of soy protein‐stabilized emulsions
TL;DR: Bioactive molecular structure and co-administration influenced the transfer behaviour, with implications for foods designed to optimize health benefits.
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Nonionic Surfactant and Interfacial Structure Impact Crystallinity and Stability of β-Carotene Loaded Lipid Nanodispersions
TL;DR: The stability, crystallization, and melting behavior of canola stearin (CaSt) solid lipid nanoparticle dispersions (SLN) and canola oil-in-water emulsions (COE) with and without 0.1 wt % β-carotene were investigated.