Journal ArticleDOI
Development of the polymer micelle carrier system for doxorubicin.
T Nakanishi,S. Fukushima,Kazuya Okamoto,Minoru Suzuki,Yasuhiro Matsumura,Masayuki Yokoyama,Teruo Okano,Yasuhisa Sakurai,Kazunori Kataoka +8 more
TLDR
The result of pre-clinical study of NK911, a polymeric micelle carrier system for doxorubicin (DOX) shows much stronger activity than the free DOX, which can entrap the sufficient amount of DOX in tumor tissue by EPR effect.About:
This article is published in Journal of Controlled Release.The article was published on 2001-07-06. It has received 566 citations till now. The article focuses on the topics: Micelle & Drug carrier.read more
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Nanocarriers as an emerging platform for cancer therapy
Dan Peer,Jeffrey M. Karp,Jeffrey M. Karp,Seungpyo Hong,Omid C. Farokhzad,Rimona Margalit,Robert Langer +6 more
TL;DR: The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
Journal ArticleDOI
The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Journal ArticleDOI
Therapeutic Nanoparticles for Drug Delivery in Cancer
TL;DR: In this paper, the authors proposed a passive targeting mechanism, active targeting strategies using ligands or antibodies directed against selected tumor targets amplify the specificity of these therapeutic nanoparticles, enabling them to carry their loaded active drugs to cancer cells by selectively using the unique pathophysiology of tumors.
Journal Article
Therapeutic Nanoparticles for Drug Delivery in Cancer
TL;DR: Multifunctional and multiplex nanoparticles are now being actively investigated and are on the horizon as the next generation of nanoparticles, facilitating personalized and tailored cancer treatment.
Journal ArticleDOI
Micellar nanocarriers: pharmaceutical perspectives.
TL;DR: This review will discuss some recent trends in using micelles as pharmaceutical carriers, including lipid-core micells, which may become the imaging agents of choice in different imaging modalities.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Formation of Polyion Complex Micelles in an Aqueous Milieu from a Pair of Oppositely-Charged Block Copolymers with Poly(ethylene glycol) Segments
Atsushi Harada,Kazunori Kataoka +1 more
TL;DR: In this paper, stable and monodispersive polyion complex micelles were prepared in an aqueous milieu through electrostatic interaction between a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments.
Journal ArticleDOI
Chain Length Recognition: Core-Shell Supramolecular Assembly from Oppositely Charged Block Copolymers
Atsushi Harada,Kazunori Kataoka +1 more
TL;DR: Molecular recognition based on length was found to occur between oppositely charged pairs of flexible and randomly coiled block copolymers in an aqueous milieu.
Journal ArticleDOI
Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor
Masayuki Yokoyama,Shigeto Fukushima,Ryuji Uehara,Kazuya Okamoto,Kazunori Kataoka,Yasuhisa Sakurai,Teruo Okano +6 more
TL;DR: It was found that a dimer of adriamycin molecules formed and that this dimer was physically entrapped in the inner core of the micelle as well as intact ADR, indicating that the physicallyEntrapped ADR played a major role in antitumor activity in vivo.
Journal Article
Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood.
Masayuki Yokoyama,Teruo Okano,Yasuhisa Sakurai,Hisao Ekimoto,Chieko Shibazaki,Kazunori Kataoka +5 more
TL;DR: PEG-P[Asp(ADR)] expressed critical suppression of tumor growth and considerably prolonged life span of the treated mice and the stabilized circulation of ADR residue in blood by binding to the block copolymer was considered to result from the micellar structure which possesses the hydrated outer shell composed of the poly(ethylene glycol) chains.
Related Papers (5)
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more