Journal ArticleDOI
Developmental genetics of the female reproductive tract in mammals
TLDR
The emerging genetic pathways that regulate female reproductive-tract formation in mammals and that are implicated in congenital abnormalities of this organ system are reviewed and it is shown that these pathways might be conserved between invertebrates and mammals.Abstract:
The female reproductive tract receives the oocytes for fertilization, supports the development of the fetus and provides the passage for birth. Although abnormalities of this organ system can result in infertility and even death, until recently relatively little was known about the genetic processes that underlie its development. By drawing primarily on mouse mutagenesis studies and the analysis of human mutations we review the emerging genetic pathways that regulate female reproductive-tract formation in mammals and that are implicated in congenital abnormalities of this organ system. We also show that these pathways might be conserved between invertebrates and mammals.read more
Citations
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Journal ArticleDOI
The biology of infertility: research advances and clinical challenges
Martin M. Matzuk,Dolores J. Lamb +1 more
TL;DR: The past six years have witnessed a virtual explosion in the identification of gene mutations or polymorphisms that cause or are linked to human infertility, but translation of these findings to the clinic remains slow, however, as do new methods to diagnose and treat infertile couples.
Journal ArticleDOI
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system.
Thomas L. Carroll,Joo-Seop Park,Shigemi Hayashi,Shigemi Hayashi,Arindam Majumdar,Arindam Majumdar,Andrew P. McMahon +6 more
TL;DR: It is shown that Wnt9b is expressed in the inductive epithelia and is essential for the development of mesonephric and metanephric tubules and caudal extension of the Müllerian duct, and this data implicate canonical Wnt signaling as one of the major pathways in the organization of the mammalian urogenital system.
Journal ArticleDOI
Prevalence and diagnosis of congenital uterine anomalies in women with reproductive failure: a critical appraisal
TL;DR: Women with RM have a high prevalence of congenital uterine anomalies and should be thoroughly investigated, and combined hysteroscopy and laparoscopy, SHG and 3D US can be used for a definitive diagnosis.
Journal ArticleDOI
Physiological and molecular determinants of embryo implantation
Shuang Zhang,Hai-Yan Lin,Shuangbo Kong,Shumin Wang,Hongmei Wang,Haibin Wang,D. Randall Armant,D. Randall Armant +7 more
TL;DR: A better understanding of underlying mechanisms governing embryo implantation should generate new strategies to rectify implantation failure and improve pregnancy rates in women.
Journal ArticleDOI
Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
Akio Kobayashi,Kin Ming Kwan,Thomas L. Carroll,Andrew P. McMahon,Cathy Mendelsohn,Richard R. Behringer,Richard R. Behringer +6 more
TL;DR: It is demonstrated that the nephric duct is essential for the elongation and maintenance of the adjacent Müllerian duct, the anlage of the female reproductive tract, and that Lim1 functions in distinct tissue compartments of the developing metanephros for both proper development of the ureteric buds and the patterns of renal vesicles for nephron formation.
References
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Journal ArticleDOI
Estrogen receptor null mice: what have we learned and where will they lead us?
John F. Couse,Kenneth S. Korach +1 more
TL;DR: The recent successful generation of double knockout, or alpha beta ERKO mice of both sexes, suggests that this receptor is also not essential to survival and was most likely not a compensatory factor in the survival of the alpha ERKO.
Journal ArticleDOI
Female development in mammals is regulated by Wnt-4 signalling
TL;DR: In the mammalian embryo, both sexes are initially morphologically indistinguishable: specific hormones are required for sex-specific development but the establishment of sexual dimorphism is under the control of both local and systemic signals.
Journal ArticleDOI
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.
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Journal ArticleDOI
Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants
Cathy Mendelsohn,David Lohnes,Didier Decimo,Thomas Lufkin,Marianne LeMeur,Pierre Chambon,Manuel Mark +6 more
TL;DR: The results clearly demonstrate that RARs are essential for vertebrate ontogenesis and therefore that retinoic acid is the active retinoid, which is required at several stages of the development of numerous tissues and organs.
Journal ArticleDOI
Pax-2 controls multiple steps of urogenital development
TL;DR: Pax-2 mouse mutants provide an animal model for human hereditary kidney diseases and data show that Pax-2 is required for multiple steps during the differentiation of intermediate mesoderm.
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