Journal ArticleDOI
Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT.
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TLDR
It is suggested that dietary fish oil may decrease the risk for cardiovascular disease through the modulation of both plasma lipids and inflammatory markers in healthy postmenopausal women.Abstract:
Background: Atherogenesis is a complex process involving both a low-grade inflammation and a disturbed lipid profile. Although dietary fish and fish oil improve the latter of these two risk factors, their impact on the former is less clear. Objective: This study addressed the effect of supplementation with fish oil in doses achievable with diet on serum C-reactive protein (CRP), interleukin-6 (IL-6), and the lipid profile. Methods and results: Thirty healthy subjects taking HRT were randomly divided into three groups and supplemented for five weeks with 14g/day safflower oil (SO), 7g/day of both safflower oil and fish oil (LFO), or 14g/day fish oil (HFO). Measurements included serum high-sensitivity CRP, IL-6 in plasma and in cell culture supernatant collected from 24-hr lipopolysaccharide (LPS)-stimulated whole blood, and lipid profile markers. CRP and IL-6 were adjusted for body mass index (BMI). Fish oil supplementation significantly decreased CRP and IL-6 compared to SO, with a greater effect in the LFO than HFO groups. Plasma triacylglycerol (TG) and the TG/HDL-C ratio were significantly lower in the HFO compared to the SO group. Conclusions: These results suggest that dietary fish oil may decrease the risk for cardiovascular disease through the modulation of both plasma lipids and inflammatory markers in healthy postmenopausal women.read more
Citations
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Journal ArticleDOI
Dietary factors and low-grade inflammation in relation to overweight and obesity
Philip C. Calder,Namanjeet Ahluwalia,Fred Brouns,Timo Buetler,Karine Clément,Karen Cunningham,Katherine Esposito,Lena S. Jönsson,Hubert Kolb,Mirian Lansink,Ascensión Marcos,Andrew N. Margioris,Nathan V. Matusheski,Herve Nordmann,John O’Brien,Giuseppe Pugliese,Salwa W. Rizkalla,Casper G. Schalkwijk,Jaakko Tuomilehto,Julia Wärnberg,Bernhard Watzl,Brigitte M. Winklhofer-Roob +21 more
TL;DR: Potential mechanisms are described and research gaps, which limit the understanding of the interaction between diet and postprandial and chronic low-grade inflammation, are identified.
Journal ArticleDOI
IL-10, IL-6, and TNF-α: Central factors in the altered cytokine network of uremia—The good, the bad, and the ugly
Peter Stenvinkel,Markus Ketteler,Richard J. Johnson,Bengt Lindholm,Roberto Pecoits-Filho,Miguel C. Riella,Olof Heimbürger,Tommy Cederholm,Matthias Girndt +8 more
TL;DR: Given the strong association between proinflammatory cytokines and complications common in end-stage renal disease, such as vascular calcification and wasting, the potential role of both general and targeted anticytokine treatment strategies in ESRD patients needs further evaluation.
Journal ArticleDOI
Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction
Teresa T. Fung,Marjorie L. McCullough,P. K. Newby,JoAnn E. Manson,James B. Meigs,Nader Rifai,Walter C. Willett,Frank B. Hu +7 more
TL;DR: Higher AHEI and aMED scores were associated with lower concentrations of biomarkers of inflammation and endothelial dysfunction and therefore may be useful as guidelines for reducing the risk of diseases involving such biological pathways.
Journal ArticleDOI
The effects of diet on inflammation: emphasis on the metabolic syndrome.
TL;DR: The whole diet approach seems particularly promising to reduce the inflammation associated with the metabolic syndrome, and Western dietary patterns warm up inflammation, while prudent dietary patterns cool it down.
Journal ArticleDOI
Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
Yuriko Adkins,Darshan S. Kelley +1 more
TL;DR: Evidence from cellular and molecular research studies indicates that the cardioprotective effects of n-3 PUFA result from a synergism between multiple, intricate mechanisms that involve antiinflammation, proresolving lipid mediators, modulation of cardiac ion channels, reduction of triglycerides, influence on membrane microdomains and downstream cell signaling pathways and antithrombotic and antiarrhythmic effects.
References
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Book
Statistical Power Analysis for the Behavioral Sciences
TL;DR: The concepts of power analysis are discussed in this paper, where Chi-square Tests for Goodness of Fit and Contingency Tables, t-Test for Means, and Sign Test are used.
Journal ArticleDOI
A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
Journal ArticleDOI
Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge
TL;DR: A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.